ASP Diagnostics

News & Perspective
Clinical Tools
Policy Updates
In Brief: Policy News
Podcasts & Webinars
Educational Multimedia
External Reports
Newsletter Highlights
Bibliography


News & Perspective

All News & Perspectives: Diagnostics


Clinical Tools

All Clinical Tools: Microbiology & diagnostics

 

Policy Updates

April 2018 - Overview of Recent Policy Initiatives and New Resources for Antimicrobial Stewardship [PDF]

January 2018 - Antimicrobial Stewardship and Rapid Diagnostic Testing in Low-Resource Settings [HTML] [PDF]

October 2017 - Rapid Diagnostic Testing in Antimicrobial Stewardship [HTML] [PDF]

 

In Brief: Policy News

Oct 17, 2018 - An editorial in Nature highlights issues with the efficiency of antimicrobial susceptibility testing, along with potential interdisciplinary interventions to improve processes and test development.

Oct 15, 2018 - During a high-level visit to the Mycetoma Research Centre (MRC) in Khartoum, Sudan, Dr. Tedros Adhanom Ghebreyesus pledged the World Health Organization's commitment to work with and support the MRC in developing better diagnostics, treatment, and prevention tools for mycetoma, an infectious disease caused by bacteria or fungi that mostly affects the feet of manual workers, laborers, and herdsmen between the ages of 15 and 30 in developing countries.

Oct 12, 2018 - The Longitude Prize published a report on "Innovation in AMR: patent trends for novel diagnostics," which revelaed that, although the last decade saw a general increase in the number of patent filings related to point-of-care diagnostics aimed at pathogens and infectious diseases, the annual number of filings has been recently declining.

Sep 28, 2018 - The Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) announced that, in December, it will open a transnational call to JPIAMR member countries and eligible countries in Asia and Africa for proposals for innovative research projects on new or improved diagnostics and surveillance strategies. The pre-proposal deadline will be February 2019.

Sep 28, 2018 - On the World Bank blog, Uzo Chukwuma, MPH, describes her realization that developing antimicrobial stewardship programs in Tanzania will require creative and collaborative strategies to boost diagnostic and surveillance capabilities while potentially integrating stewardship into existing programs (eg, malaria prevention).

All In Brief: Policy News


Podcasts & Webinars

Dec 12, 2017 View the CIDRAP-ASP hosted webinar with Dr. Romney Humphries as she presents "Improving the Antibiotic Stewardship Value of Clinical Microbiology Tests." 

 

Educational Multimedia

2018 Nebraska Antimicrobial Stewardship Summit: Role of the Laboratory in Antimicrobial Stewardship: Presented by Daniel Diekema, MD (Nebraska Antimicrobial Stewardship Assessment and Promotion Program)

Clinical Microbiology Case Studies (American Society for Microbiology) - Case study presentations explore the microbiology lab’s role in susceptibility testing, prescribing decisions, and diagnosis of antibiotic-related enteric infections.

Diagnostic Stewardship: Does Optimisation of the Blood Culture Pathway Have a Role to Play? Presented by Dr. Mike Weinbren (2018 British Society for Microbial Technology Annual Scientific Conference: Rapid Diagnostics—Time is Relative)

Diagnostic Tests & Antibiotic Resistance (The George Washington University Milken Institute School of Public Health Antibiotic Resistance Action Center and AdvaMedDx) - ARAC, in partnership with AdvaMedDx, developed infographics that highlight how diagnostic tests can be utilized to help combat antibiotic resistance.

Fighting Superbugs in India: A Short Film (The Longitude Prize and India’s Biotechnology Industry Research Assistance Council) - A 10-minute film follows stories from India where antibiotic resistance is growing rapidly and features interviews with doctors, patients, and researchers to highlight the urgency of the problem. Filmmakers also spoke with teams competing for the Longitude Prize to make rapid diagnostic tests that will hopefully help address the spread of superbugs in India and globally.

Focusing Stewardship: Changing the Culture of Culturing (Podcast featuring James Lewis, PharmD, and Julia Szymczak, PhD) (The Society for Healthcare Epidemiology of America)

Hard to Resist (The Institute on Science for Global Policy) - A March 2018 ISGP podcast ponders the balance between the potential to obtain comprehensive data on antimicrobial resistance from DNA sequencing technologies and the usefulness of applying such data within a clinical context.

The Impact of Rapid Diagnostics on Antimicrobial Stewardship (Presentation featuring Dianne Tabb, PharmD, MT) (Georgia Department of Public Health Antibiotic Stewardship Program) [Presentation] [Slides]

The Methods of Antimicrobial Susceptibility Testing Educational Resource (MASTER) eLearning Curriculum (Centers for Disease Control and Prevention) - The three, hour-long courses provide online training in the area of antimicrobial susceptibility testing for bacteria isolated from clinical specimens.

Rapid Diagnostics, Bad Bugs and Antibiotics: Not That Easy: Presented by Dr. Vanya Gant (2018 British Society for Microbial Technology Annual Scientific Conference: Rapid Diagnostics—Time is Relative)

Rapid Diagnostic Testing of Positive Blood Cultures & Impact on Antimicrobial Stewardship: Presented by Brad Crane, PharmD (Luminex Corporation Xtalks)

Rapid Metagenomic Diagnosis of Hospital Acquired Pneumonia: Presented by Dr. Justin O’Grady (2018 British Society for Microbial Technology Annual Scientific Conference: Rapid Diagnostics—Time is Relative)

Sepsis Educational Tools (The UK Sepsis Trust) - The UK Sepsis Trust developed a manual and educational videos on screening, diagnostics, and care of patients with suspected or confirmed sepsis, highlighting the role of antimicrobial stewardship and appropriate empirical antimicrobial use.

Show Me the Money! Antimicrobials vs. Rapid Diagnostic Pipelines by Melissa D. Johnson, PharmD, MHS, and Romney M. Humphries, PhD (2017 Society of Infectious Diseases Pharmacists Annual Meeting)

Teamwork for UTI diagnosis: Practical tools and skills: Presentation by Heidi Wald, MD, MSPH(Colorado Hospital Association)

Utility of Rapid Diagnostics in Staphylococcus aureus Bacteremia in Antimicrobial Stewardship Programs (Society of Infectious Diseases Pharmacists) - The course will review the commercially available rapid diagnostic testing available to be used in treating patients with S. aureus, technologies associated with available rapid testing, ways that rapid diagnostics can help in the management of patients with S. aureus, and ways to incorporate rapid diagnostics into antimicrobial stewardship programs to improve outcomes.


External Reports

July 2018 2018 BASHH UK National Guidelines for the Management of Infection with Mycoplasma genitalium (British Association for Sexual Health and HIV)

January 2018 - Accelerating Diagnostics Use to Prevent AMR (FIND)

September 2017 - Medical devices: Capabilities and challenges of technologies to enable rapid diagnoses of infectious diseases (US Government Accountability Office)

September 2017 - Recommendations for Incentivizing the Development of Therapeutics, Diagnostics, and Vaccines to Combat Antibiotic-Resistance (US Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria)

May 2017 - Changing Diagnostic Paradigms for Microbiology (American Academy of Microbiology)

January 2017 - Unleashing the Power of Diagnostic Tests in the Fight Against Antibiotic Resistance (The George Washington University Milken Institute School of Public Health Antibiotic Resistance Action Center and AdvaMedDx)

All External Reports


Newsletter Highlights

Nov 8, 2018 - In Clinics in Chest Medicine, Sarah Sungurlu, DO, and Robert A. Balk, MD, review situations in which biomarkers can be used with clinical judgment to guide antibiotic management and duration of therapy for pneumonia.

Nov 8, 2018 - In the International Journal of Antimicrobial Agents, Robert J. van de Peppel, MSc, et al modeled polymerase chain reaction (PCR)–based diagnostics and empirical therapy choices based on epidemiologic data of triazole resistance in invasive aspergillosis, finding that the implementation of PCR testing was projected to result in treatment-susceptibility mismatches of less than 5% when modeled against a triazole resistance rate up to 20%.

Nov 8, 2018 - In the American Journal of Infection Control, Salma Abbas, MBBS, MPH, et al describe low acceptance of pharmacist recommendations to de-escalate antibiotic therapy based on notification of rapid respiratory panel test results in a Virginia hospital.

Nov 1, 2018 - In a video for Healio, CIDRAP-ASP Advisory Committee member Debra A. Goff, PharmD, describes how hospital antimicrobial stewardship team members can advocate for rapid diagnostics.

Nov 1, 2018 - On preprint server bioRxiv, David McAdams, PhD, MS, et al evaluate the use of epidemiologic theory and data to assess the potential of rapid point-of-care diagnostics as a means to limit or reverse selection for antimicrobial resistance.

All Newsletters Highlights

 

Bibliography

(Last updated Oct 4, 2018)

Arastehfar A, Fang W, Pan W, et al. YEAST PANEL multiplex PCR for identification of clinically important yeast species: stepwise diagnostic strategy, useful for developing countries. Diagn Microbiol Infect Dis 2018 (published online Sep 21)

Barnes L, Heithoff DM, Mahan SP, et al. Smartphone-based pathogen diagnosis in urinary sepsis patients. EBioMedicine 2018 (published online Sep 20)

Bouza E, Onori R, Semiglia-Chong MA, et al. Fast track SSTI management program based on a rapid molecular test (GeneXpert®MRSA/SA SSTI) and antimicrobial stewardship. J Microbiol Immunol Infect 2018 (published online Aug 31)

Cattoir L, Coorevits L, Leroux-Roels I, et al. Improving timelines in reporting results from positive blood cultures: simulation of impact of rapid identification on therapy on a real-life cohort.Eur J Clin Microbiol Infect Dis 2018 (published online Sep 5)

Claeys KC, Schlaffer KE, Heil EL, et al. Validation of an antimicrobial stewardship driven Verigene blood-culture gram-negative treatment algorithm to improve appropriateness of antibiotics.Open Forum Infect Dis 2018 (published online Sep 15)

Eichinger A, Hagen A, Meyer-Buhn M, et al. Clinical benefits of introducing real-time multiplex PCR for cerebrospinal fluid as routine diagnostic at a tertiary care pediatric center.Infection 2018 (published online Sep 5)

Evans SR, Tran TTT, Hujer AM, et al. Rapid molecular diagnostics to inform empiric use of ceftazidime/avibactam and ceftolozane/tazobactam against Pseudomonas aeruginosa: PRIMERS IV.Clin Infect Dis 2018 (published online Sep 20)

Fabre V, Milstone AM, Keller SC, et al. Prescribers’ knowledge, attitudes and perceptions about blood culturing practices for adult hospitalized patients: a call for action. Infect Control Hosp Epidemiol 2018 (published online Sep 18)

Hill R, Rennie MY, Douglas J. Using bacterial fluorescence imaging and antimicrobial stewardship to guide wound management practices: a case series. Ostomy Wound Manage 2018 Aug;64(8):18-28

Lowman W. Minimum inhibitory concentration-guided antimicrobial therapy—the Achilles heel in the antimicrobial stewardship agenda. S Afr Med J 2018 Aug 28;108(9):710-2

Ramakrishnan B, Gopalakrishnan R, Senthur Nambi P, et al. Utility of multiplex polymerase chain reaction (PCR) in diarrhea—an Indian perspective. Indian J Gastroenterol 2018 (published online Sep 22)

Rautemaa-Richardson R, Rautemaa V, Al-Wathiqi F, et al. Impact of a diagnostics-driven antifungal stewardship programme in a UK tertiary referral teaching hospital. J Antimicrob Chemother 2018 (published online Sep 24)

Richards KA, Cesario S, Best SL, et al. Reflex urine culture testing in an ambulatory urology clinic: implications for antibiotic stewardship in urology. Int J Urol 2018 (published online Sep 16)

Steuten L, Mewes J, Lepage-Nefkens I, et al. Is procalcitonin biomarker-guided antibiotic therapy a cost-effective approach to reduce antibiotic resistant and Clostridium difficile infections in hospitalized patients? OMICS 2018 Sep;22(9):616-25

Tarai B, Das P. FilmArray meningitis/encephalitis (ME) panel, a rapid molecular platform for diagnosis of CNS infections in a tertiary care hospital in North India: one-and-half-year review.Neurol Sci 2018 (published online Sep 25)

 All Bibliography: Diagnostics

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