ASP Diagnostics

News & Perspective
Clinical Tools
Policy Updates
In Brief: Policy News
Podcasts & Webinars
Educational Multimedia
External Reports
Newsletter Highlights
Bibliography


News & Perspective

All News & Perspectives: Diagnostics


Clinical Tools

All Clinical Tools: Microbiology & diagnostics

 

Policy Updates

April 2018 - Overview of Recent Policy Initiatives and New Resources for Antimicrobial Stewardship [PDF]

January 2018 - Antimicrobial Stewardship and Rapid Diagnostic Testing in Low-Resource Settings [HTML] [PDF]

October 2017 - Rapid Diagnostic Testing in Antimicrobial Stewardship [HTML] [PDF]

 

In Brief: Policy News

Sep 13, 2018 - The Diagnostics for One Health and User Driven Solutions for AMR (DOSA) program will begin with a meeting on Sep 24 and 25 at the Indian Institute of Technology. DOSA brings together a multidisciplinary team from the UK and India to create rapid diagnostic solutions to fight antimicrobial resistance in community healthcare, dairy farming, and aquaculture.

Sep 7, 2018 - In the Pharmaceutical Journal, Julia Robinson, MSc, describes recent statements affirming the importance and integration of rapid diagnostics in UK antimicrobial stewardship programs made by Dame Sally Davies, MBChB, MS, and Lord Jim O'Neill to a House of Commons committee inquiry into the problem of antimicrobial resistance.

Sep 5, 2018 - In a commission published in The Lancet Global Health, Margaret E. Kruk, MD, et al discuss factors involved in building high-quality health systems, which include antimicrobial stewardship and appropriate diagnostic testing, in meeting the Sustainable Development Goals for low- and middle- income countries.

Aug 13, 2018 - On Contagion, Elizabeth Hirsch, PharmD, highlights new and revised breakpoints for ceftaroline, daptomycin, ciprofloxacin, levofloxacin, cefiderocol, and meropenem-vaborbactam approved by the Clinical and Laboratory Standards Institute's Subcommittee on Antimicrobial Susceptibility and subject to official approval in January 2019.

Jul 10, 2018 - A new nonprofit and publicly supported initiative—the Antibiotic Resistance Monitoring, Analysis and Diagnostics Alliance (ARMADA)—launched with the intent to combine global collection of bacterial isolates and data that will inform development of surveillance measures and diagnostic tests.

All In Brief: Policy News


Podcasts & Webinars

Dec 12, 2017 View the CIDRAP-ASP hosted webinar with Dr. Romney Humphries as she presents "Improving the Antibiotic Stewardship Value of Clinical Microbiology Tests." 

 

Educational Multimedia

2018 Nebraska Antimicrobial Stewardship Summit: Role of the Laboratory in Antimicrobial Stewardship: Presented by Daniel Diekema, MD (Nebraska Antimicrobial Stewardship Assessment and Promotion Program)

Clinical Microbiology Case Studies (American Society for Microbiology) - Case study presentations explore the microbiology lab’s role in susceptibility testing, prescribing decisions, and diagnosis of antibiotic-related enteric infections.

Diagnostic Stewardship: Does Optimisation of the Blood Culture Pathway Have a Role to Play? Presented by Dr. Mike Weinbren (2018 British Society for Microbial Technology Annual Scientific Conference: Rapid Diagnostics—Time is Relative)

Diagnostic Tests & Antibiotic Resistance (The George Washington University Milken Institute School of Public Health Antibiotic Resistance Action Center and AdvaMedDx) - ARAC, in partnership with AdvaMedDx, developed infographics that highlight how diagnostic tests can be utilized to help combat antibiotic resistance.

Fighting Superbugs in India: A Short Film (The Longitude Prize and India’s Biotechnology Industry Research Assistance Council) - A 10-minute film follows stories from India where antibiotic resistance is growing rapidly and features interviews with doctors, patients, and researchers to highlight the urgency of the problem. Filmmakers also spoke with teams competing for the Longitude Prize to make rapid diagnostic tests that will hopefully help address the spread of superbugs in India and globally.

Focusing Stewardship: Changing the Culture of Culturing (Podcast featuring James Lewis, PharmD, and Julia Szymczak, PhD) (The Society for Healthcare Epidemiology of America)

Hard to Resist (The Institute on Science for Global Policy) - A March 2018 ISGP podcast ponders the balance between the potential to obtain comprehensive data on antimicrobial resistance from DNA sequencing technologies and the usefulness of applying such data within a clinical context.

The Impact of Rapid Diagnostics on Antimicrobial Stewardship (Presentation featuring Dianne Tabb, PharmD, MT) (Georgia Department of Public Health Antibiotic Stewardship Program) [Presentation] [Slides]

The Methods of Antimicrobial Susceptibility Testing Educational Resource (MASTER) eLearning Curriculum (Centers for Disease Control and Prevention) - The three, hour-long courses provide online training in the area of antimicrobial susceptibility testing for bacteria isolated from clinical specimens.

Rapid Diagnostics, Bad Bugs and Antibiotics: Not That Easy: Presented by Dr. Vanya Gant (2018 British Society for Microbial Technology Annual Scientific Conference: Rapid Diagnostics—Time is Relative)

Rapid Diagnostic Testing of Positive Blood Cultures & Impact on Antimicrobial Stewardship: Presented by Brad Crane, PharmD (Luminex Corporation Xtalks)

Rapid Metagenomic Diagnosis of Hospital Acquired Pneumonia: Presented by Dr. Justin O’Grady (2018 British Society for Microbial Technology Annual Scientific Conference: Rapid Diagnostics—Time is Relative)

Sepsis Educational Tools (The UK Sepsis Trust) - The UK Sepsis Trust developed a manual and educational videos on screening, diagnostics, and care of patients with suspected or confirmed sepsis, highlighting the role of antimicrobial stewardship and appropriate empirical antimicrobial use.

Show Me the Money! Antimicrobials vs. Rapid Diagnostic Pipelines by Melissa D. Johnson, PharmD, MHS, and Romney M. Humphries, PhD (2017 Society of Infectious Diseases Pharmacists Annual Meeting)

Teamwork for UTI diagnosis: Practical tools and skills: Presentation by Heidi Wald, MD, MSPH(Colorado Hospital Association)

Utility of Rapid Diagnostics in Staphylococcus aureus Bacteremia in Antimicrobial Stewardship Programs (Society of Infectious Diseases Pharmacists) - The course will review the commercially available rapid diagnostic testing available to be used in treating patients with S. aureus, technologies associated with available rapid testing, ways that rapid diagnostics can help in the management of patients with S. aureus, and ways to incorporate rapid diagnostics into antimicrobial stewardship programs to improve outcomes.


External Reports

July 2018 2018 BASHH UK National Guidelines for the Management of Infection with Mycoplasma genitalium (British Association for Sexual Health and HIV)

January 2018 - Accelerating Diagnostics Use to Prevent AMR (FIND)

September 2017 - Medical devices: Capabilities and challenges of technologies to enable rapid diagnoses of infectious diseases (US Government Accountability Office)

September 2017 - Recommendations for Incentivizing the Development of Therapeutics, Diagnostics, and Vaccines to Combat Antibiotic-Resistance (US Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria)

May 2017 - Changing Diagnostic Paradigms for Microbiology (American Academy of Microbiology)

January 2017 - Unleashing the Power of Diagnostic Tests in the Fight Against Antibiotic Resistance (The George Washington University Milken Institute School of Public Health Antibiotic Resistance Action Center and AdvaMedDx)

All External Reports


Newsletter Highlights

Sep 13, 2018 - On Contagion, Julie Ann Justo, PharmD, MS, describes the interplay between rapid diagnostics, prediction scores, and choices about empirical therapy in the decision-making process of an antimicrobial stewardship team. 

Sep 13, 2018 In the Pharmaceutical Journal, Julia Robinson, MSc, describes recent statements affirming the importance and integration of rapid diagnostics in UK antimicrobial stewardship programs made by Dame Sally Davies, MBChB, MS, and Lord Jim O'Neill to a House of Commons committee inquiry into the problem of antimicrobial resistance.

Sep 13, 2018 - In news from the University of Alabama in Huntsville, Diana LaChance, MA, describes the research of Surangi Jayawardena, PhD, who is developing low-cost, point-of-care diagnostic techniques for tuberculosis and chlamydia.

Sep 13, 2018 - Last week, the Clinical and Laboratory Standards Institute's Subcommittee on Antimicrobial Susceptibility Testing published a rationale authored by Romney M. Humphries, PhD, on colistin breakpoints for Pseudomonas aeruginosa and Acinetobacter species. (NB: You must enter a name and email address to download the document.)

Sep 13, 2018 - On the Small Things Considered blog, Michael Schmidt, PhD, discusses the implications of research that may enable clinicians to obtain faster susceptibility results for uropathogens.

Sep 13, 2018 - In the European Journal of Clinical Microbiology & Infectious Diseases, Lien Cattoir, MD, MS, et al discuss a simulated integration of rapid molecular testing and matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometry for 158 positive blood cultures at a Belgian hospital, finding that the use of these methods would necessitate rapid communication to adapt antimicrobial therapy in about one-third of patients.

All Newsletters Highlights

 

Bibliography

(Last updated Sep 7, 2018)

Ben-Zvi H, Drozdinsky G, Kushnir S, et al. Influence of GeneXpert MRSA/SA test implementation on clinical outcomes of Staphylococcus aureus bacteremia—a before-after retrospective study. Diagn Microbiol Infect Dis 2018 (published online Aug 29)

Bukowski PM, Jacoby JS, Jameson AP, et al. Implementation of rapid diagnostic testing without active stewardship team notification for gram-positive blood cultures in a community teaching hospital. Antimicrob Agents Chemother 2018 (published online Aug 27)

Fidler G, Leiter E, Kocsube S, et al. Validation of a simplex PCR assay enabling reliable identification of clinically relevant Candida species. BMC Infect Dis 2018 (published online Aug 13)

Gal M, Francis NA, Hood K, et al. Matching diagnostics development to clinical need: target product profile development for a point of care test for community-acquired lower respiratory tract infection. PLoS One 2018 (published online Aug 1)

Gutierrez-Gutierrez B, Morales I, Perez-Galera S, et al. Predictive value of the kinetics of procalcitonin and C-reactive protein for early clinical stability in patients with bloodstream infections due to gram-negative bacteria. Diagn Microbiol Infect Dis 2018 (published online Aug 3)

Jeon YD, Seong H, Kim D, et al. Impact of matrix-assisted laser desorption/ionization time of flight mass spectrometric evaluation on the clinical outcomes of patients with bacteremia and fungemia in clinical settings lacking an antimicrobial stewardship program: a pre-post quasi experimental study. BMC Infect Dis 2018 (published online Aug 9)

Kamel NA, El-Tayeb WN, El-Ansary MR, et al. Phenotypic screening and molecular characterization of carbapenemase-producing gram-negative bacilli recovered from febrile neutropenic pediatric cancer patients in Egypt. PLoS One 2018 (published online Aug 29)

O’Brien MP, Francis JR, Marr IM, et al. Impact of cerebrospinal fluid multiplex assay on diagnosis and outcomes of central nervous system infections in children: a before and after cohort study. Pediatr Infect Dis J 2018 Sep;37(9):868-71

Puerta-Alcalde P, Cardozo C, Suarez-Lledo M, et al. Current time-to-positivity of blood cultures in the febrile neutropenia: a tool to be used in stewardship de-escalation strategies. Clin Microbiol Infect 2018 (published online Aug 7)

Suri V, Mendiratta L, Chatterjee S, et al. Unusual presentation of Varicella zoster virus meningitis—role of molecular rapid diagnostics in diagnosis and antimicrobial stewardship. Ann Indian Acad Neurol 2018 Apr-Jun;21(2):168-9

Wirz Y, Meier MA, Bouadma L, et al. Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials. Crit Care 2018 (published online Aug 15)

Yusuf E, Harners RL. What WHO’s List of Essential Diagnostics means for clinical microbiology laboratories and antimicrobial stewardship practice worldwide. Clin Microbiol Infect 2018 (published online Aug 23)

Zhou M, Wang Y, Liu C, et al. Comparison of five commonly used automated susceptibility testing methods for accuracy in the China Antimicrobial Resistance Surveillance System (CARSS) hospitals. Infect Drug Resist 2018 (published online Aug 30)

 All Bibliography: Diagnostics

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