ASP Diagnostics

News & Perspective
Clinical Tools
Policy Updates
In Brief: Policy News
Podcasts & Webinars
Educational Multimedia
External Reports
Newsletter Highlights
Bibliography


News & Perspective

All News & Perspectives: Diagnostics


Clinical Tools

All Clinical Tools: Microbiology & diagnostics

 

Policy Updates

April 2018 - Overview of Recent Policy Initiatives and New Resources for Antimicrobial Stewardship [PDF]

January 2018 - Antimicrobial Stewardship and Rapid Diagnostic Testing in Low-Resource Settings [HTML] [PDF]

October 2017 - Rapid Diagnostic Testing in Antimicrobial Stewardship [HTML] [PDF]

 

In Brief: Policy News

Dec 18, 2018 On the blog of the Longitude Prize, Christine Carson, PhD, discusses how a lack of consensus on the measurement of antimicrobial-resistant infections, inconsistent diagnostic coding, and variable susceptibility testing methods have led to difficulty in quantifying the scale of antimicrobial resistance.

Nov 29, 2018 - In the African Journal of Laboratory Medicine, Iruka A. Okeke, PhD, MSc, discusses opportunitites to build laboratory capacity and integrate molecular diagnostic methods in African healthcare settings, along with examples of local innovations.

Nov 26, 2018 - The US Centers for Disease Control and Prevention announced that more than $15 million USD would be awarded to 41 projects to explore gaps in knowledge about antibiotic resistance and pilot innovative solutions, including projects to develop a rapid phenotypic susceptibility test for Neisseria gonorrhoeae, assess risk of hospital microbial transmission based on shotgun metagenome sequencing, evaluate diagnostic tests to identify Mycoplasma pneumoniae, study the impact of a rapid test to diagnose coccidioidomycosis, and more.

Oct 17, 2018 - An editorial in Nature highlights issues with the efficiency of antimicrobial susceptibility testing, along with potential interdisciplinary interventions to improve processes and test development.

Oct 15, 2018 - During a high-level visit to the Mycetoma Research Centre (MRC) in Khartoum, Sudan, Dr. Tedros Adhanom Ghebreyesus pledged the World Health Organization's commitment to work with and support the MRC in developing better diagnostics, treatment, and prevention tools for mycetoma, an infectious disease caused by bacteria or fungi that mostly affects the feet of manual workers, laborers, and herdsmen between the ages of 15 and 30 in developing countries.

All In Brief: Policy News


Podcasts & Webinars

Dec 12, 2017 View the CIDRAP-ASP hosted webinar with Dr. Romney Humphries as she presents "Improving the Antibiotic Stewardship Value of Clinical Microbiology Tests." 

 

Educational Multimedia

2018 Nebraska Antimicrobial Stewardship Summit: Role of the Laboratory in Antimicrobial Stewardship: Presented by Daniel Diekema, MD (Nebraska Antimicrobial Stewardship Assessment and Promotion Program)

An ASM-CLSI Webinar Series on Antimicrobial Susceptibility Testing: Fundamentals of Susceptibility Testing, Reporting, and Test Validation (Self-Study Series) (American Society for Microbiology, Clinical and Laboratory Standards Institute, and Accelerate Diagnostics)

Clinical Microbiology Case Studies (American Society for Microbiology) - Case study presentations explore the microbiology lab’s role in susceptibility testing, prescribing decisions, and diagnosis of antibiotic-related enteric infections.

Diagnostic Stewardship: Does Optimisation of the Blood Culture Pathway Have a Role to Play? Presented by Dr. Mike Weinbren (2018 British Society for Microbial Technology Annual Scientific Conference: Rapid Diagnostics—Time is Relative)

Diagnostic Tests & Antibiotic Resistance (The George Washington University Milken Institute School of Public Health Antibiotic Resistance Action Center and AdvaMedDx) - ARAC, in partnership with AdvaMedDx, developed infographics that highlight how diagnostic tests can be utilized to help combat antibiotic resistance.

Fighting Superbugs in India: A Short Film (The Longitude Prize and India’s Biotechnology Industry Research Assistance Council) - A 10-minute film follows stories from India where antibiotic resistance is growing rapidly and features interviews with doctors, patients, and researchers to highlight the urgency of the problem. Filmmakers also spoke with teams competing for the Longitude Prize to make rapid diagnostic tests that will hopefully help address the spread of superbugs in India and globally.

Focusing Stewardship: Changing the Culture of Culturing (Podcast featuring James Lewis, PharmD, and Julia Szymczak, PhD) (The Society for Healthcare Epidemiology of America)

Hard to Resist (The Institute on Science for Global Policy) - A March 2018 ISGP podcast ponders the balance between the potential to obtain comprehensive data on antimicrobial resistance from DNA sequencing technologies and the usefulness of applying such data within a clinical context.

The Human Diagnosis Project (American Medical Association, Association of American Medical Colleges, American Board of Internal Medicine, American Board of Medical Specialties, National Association of Community Health Centers, Association of Clinicians for the Underserved, the Dartmouth Institute for Health Policy & Clinical Practice)

The Impact of Rapid Diagnostics on Antimicrobial Stewardship (Presentation featuring Dianne Tabb, PharmD, MT) (Georgia Department of Public Health Antibiotic Stewardship Program) [Presentation] [Slides]

The Methods of Antimicrobial Susceptibility Testing Educational Resource (MASTER) eLearning Curriculum (Centers for Disease Control and Prevention) - The three, hour-long courses provide online training in the area of antimicrobial susceptibility testing for bacteria isolated from clinical specimens.

Rapid Diagnostics, Bad Bugs and Antibiotics: Not That Easy: Presented by Dr. Vanya Gant (2018 British Society for Microbial Technology Annual Scientific Conference: Rapid Diagnostics—Time is Relative)

Rapid Diagnostic Testing of Positive Blood Cultures & Impact on Antimicrobial Stewardship: Presented by Brad Crane, PharmD (Luminex Corporation Xtalks)

Rapid Metagenomic Diagnosis of Hospital Acquired Pneumonia: Presented by Dr. Justin O’Grady (2018 British Society for Microbial Technology Annual Scientific Conference: Rapid Diagnostics—Time is Relative)

Sepsis Educational Tools (The UK Sepsis Trust) - The UK Sepsis Trust developed a manual and educational videos on screening, diagnostics, and care of patients with suspected or confirmed sepsis, highlighting the role of antimicrobial stewardship and appropriate empirical antimicrobial use.

Show Me the Money! Antimicrobials vs. Rapid Diagnostic Pipelines by Melissa D. Johnson, PharmD, MHS, and Romney M. Humphries, PhD (2017 Society of Infectious Diseases Pharmacists Annual Meeting)

Teamwork for UTI diagnosis: Practical tools and skills: Presentation by Heidi Wald, MD, MSPH(Colorado Hospital Association)

Utility of Rapid Diagnostics in Staphylococcus aureus Bacteremia in Antimicrobial Stewardship Programs (Society of Infectious Diseases Pharmacists) - The course will review the commercially available rapid diagnostic testing available to be used in treating patients with S. aureus, technologies associated with available rapid testing, ways that rapid diagnostics can help in the management of patients with S. aureus, and ways to incorporate rapid diagnostics into antimicrobial stewardship programs to improve outcomes.


External Reports

December 2018 The Detection and Reporting of Colistin Resistance (World Health Organization Global Antimicrobial Resistance Surveillance System). 

October 2018 - Innovation in AMR: patent trends for novel diagnostics (The Longitude Prize)

July 2018 2018 BASHH UK National Guidelines for the Management of Infection with Mycoplasma genitalium (British Association for Sexual Health and HIV)

January 2018 - Accelerating Diagnostics Use to Prevent AMR (FIND)

September 2017 - Medical devices: Capabilities and challenges of technologies to enable rapid diagnoses of infectious diseases (US Government Accountability Office)

All External Reports


Newsletter Highlights

Jan 17, 2019 - The Foundation for Innovative New Diagnostics (FIND) extended the deadline of its call for partners to join the AMR Diagnostics Use Accelerator to improve the care of children and adolescents presenting with acute febrile illness in low- and middle-income countries until Jan 28.

Jan 17, 2019 - In Diagnostic Microbiology and Infectious Disease, Olivia Ellis, PhD, MS, MPH, et al describe how, in the absence of a commercially available rapid test for N gonorrhoeae antimicrobial susceptibility, a real-time polymerase chain reaction assay was validated as concordant with expected results, with an interpretable genotype yielded from 57.2% of 1,370 asymptomatic patients, 480 of whom could potentially be treated with ciprofloxacin.

Jan 17, 2019 - On the University of Nebraska Medical Center Division of Infectious Diseases blog, Raj Karnatak, MBBS, summarizes discussions from a recent journal club that focused on the strengths and weaknesses of a novel assay for the early diagnosis of sepsis.

Jan 17, 2019 - The European Centre for Disease Prevention and Control published an expert consensus protocol on colistin resistance detection and characterization for the European genomic surveillance of carbapenem- and colistin-resistant Enterobacteriaceae survey.

Jan 10, 2019 - The Longitude Prize blog summarizes the 2-day Accelerator Programme, which aimed to help 21 teams working across India build plans to bring to market their rapid diagnostic tests to reduce antimicrobial resistance.

All Newsletters Highlights

 

Bibliography

(Last updated Jan 3, 2019)

Barnes GK, Gudina EK, Berhane M, et al. New molecular tools for meningitis diagnostics in Ethiopia—a necessary step towards improving antimicrobial prescription. BMC Infect Dis 2018 (published online Dec 20)

Cole JL. Implementation of the procalcitonin assay in a rural hospital.Hosp Pharm 2018 Dec;53(6):395-402

Dray S, Coiffard B, Persico N, et al. Are tracheal surveillance cultures useful in the intensive care unit? Ann Transl Med 2018 Nov;6(21):421

Dyar OJ, Moran-Gilad J, Greub G, et al. Diagnostic stewardship: are we using the right term? Clin Microbiol Infect 2018 (published online Dec 27)

Gous NM, Onyebujoh PC, Abimiku A, et al. The role of connected diagnostics in strengthening regional, national and continental African disease surveillance. Afr J Lab Med 2018;7(2)

Grundmann H, Gelband H. Antimicrobial resistance surveillance with whole genome sequencing in Africa: it’s (about) time. Afr J Lab Med 2018;7(2)

Gutierrez C, Somoskovi A, Natarajan K, et al. Need for better adherence to optimal incubation temperature for quality laboratory diagnostics and antibiotic resistance monitoring. Afr J Lab Med 2018;7(2)

Hayashi D, Akashi Y, Suzuki H, et al. Implementation of point-of-care molecular diagnostics for Mycoplasma pneumoniae ensures the correct antimicrobial prescription for pediatric pneumonia patients. Tohoku J Exp Med 2018;246(4):225-31

Henig O, Kaye KS, Chandramohan S, et al. The hypothetical impact of Accelerate Pheno (ACC) on time to effective therapy and time to definitive therapy for bloodstream infections due to drug-resistant gram-negative bacilli. Antimicrob Agents Chemother 2018 (published online Dec 17)

Holmes EAF, Harris SD, Hughes A, et al. Cost-effectiveness analysis of the use of point-of-care C-reactive protein testing to reduce antibiotic prescribing in primary care. Antibiotics (Basel) 2018 (published online Dec 7)

Lamy B. Blood culture time-to-positivity: making use of the hidden information. Clin Microbiol Infect 2018 (published online Dec 20)

Lee BR, Hassan F, Jackson MA, et al. Impact of multiplex molecular assay turn-around-time on antibiotic utilization and clinical management of hospitalized children with acute respiratory tract infections. J Clin Virol 2018 (published online Nov 23)

Maxson T, Blancett CD, Graham AS, et al. Rapid antibiotic susceptibility testing from blood culture bottles with species agnostic real-time polymerase chain reaction. PLoS One 2018 (published online Dec 13)

Murri R, Camici M, Posteraro B, et al. Performance evaluation of the (1,3)-β-D-glucan detection assay in non-intensive care unit adult patients. Infect Drug Resist 2018 (published online Dec 20)

Oviano M, Bou G. Matrix-assisted laser desorption ionization–time of flight mass spectrometry for the rapid detection of antimicrobial resistance mechanisms and beyond. Clin Microbiol Rev 2018 (published online Nov 28)

Sullivan KV, Morgan DJ, Leekha S. Use of diagnostic stewardship practices to improve urine culturing among SHEA Research Network hospitals. Infect Control Hosp Epidemiol 2018 (published online Dec 7)

Townsend J, Adams V, Galiatsatos P, et al. Procalcitonin-guided antibiotic therapy reduces antibiotic use for lower respiratory tract infections in a US medical center: results of a clinical trial.Open Forum Infect Dis 2018 (published online Dec 3)

Tseng AS, Kasule SN, Rice F, et al. Is it actionable? An evaluation of the rapid PCR-based blood culture identification panel on the management of gram-positive and gram-negative blood stream infections. Open Forum Infect Dis 2018 (published online Dec 11)

Wang F, Liu JW, Liu HY, et al. Evaluation of the accuracy of molecular assays targeting the mutation A2059G for detecting high-level azithromycin resistance in Neisseria gonorrhoeae: a systematic review and meta-analysis. Infect Drug Resist 2018 (published online Dec 28)

Wenzler E, Lee M, Wu TJ, et al. Performance of ceftazidime/avibactam susceptibility testing methods against clinically relevant gram-negative organisms. J Antimicrob Chemother 2018 (published online Dec 10)

Yalamanchili H, Dandachi D, Okhuysen PC. Use and interpretation of enteropathogen multiplex nucleic acid amplification tests in patients with suspected infectious diarrhea.Gastroenterol Hepatol (NY) 2018 Nov;14(11):646-52

 All Bibliography: Diagnostics

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