ASP Newsletter Highlights

Feb 14, 2019 - On Mar 6, Xtalks will host a webinar on "Reconfirming the Group A Strep Diagnostic Algorithm with Molecular Confirmation," featuring a presentation from Paul Lephart, PhD.

Feb 14, 2019 - In Clinical Chemistry and Laboratory Medicine, Philipp Schuetz, Dr Med, MPH, et al summarize a meeting of experts that sought to develop evidence-based algorithms for the use of procalcitonin testing in antibiotic stewardship programs, finding that algorithms incorporating illness severity and the probability of bacterial infection have the potential to improve patient care when combined with ongoing clinical education and feedback. 

Feb 14, 2019 - In the Journal of Antimicrobial Chemotherapy, Saikat Paul et al describe the potential of stable isotope labeling by or with amino acids in cell culture (SILAC) for detecting fluconazole resistance in Candida tropicalis by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF), especially for Asian countries experiencing increases in drug-resistant C tropicalis

Feb 14, 2019 - In Antimicrobial Agents and Chemotherapy, Sebastian M. Gygli, PhD, MSc, et al found that data on Mycobacterium tuberculosis resistance to 11 antituberculosis drugs inferred by whole-genome sequencing were comparable to resistance profiles identified with two phenotypic methods.

Feb 7, 2019 - In Diagnostic Microbiology and Infectious Disease, Lauge Farnaes, MD, PhD, et al evaluate the use of cell-free plasma next generation sequencing (CFPNGS) for 15 children hospitalized with community-acquired pneumonia in a US hospital, finding that CFPNGS identified a pathogen in 86% of patients, and that changes in antibiotic management were made in 47% of children as a result of the test.

Feb 7, 2019 - In the Journal of Hospital Infection, Hilary Humphreys, MBBCh, and David C. Coleman, ScD, PhD, review ways in which whole-genome sequencing has transformed the investigation of hospital and community outbreaks of methicillin-resistant Staphylococcus aureus, along with its future potential for routine use of time-sensitive data to understand transmission.

Jan 31, 2019 - In Antimicrobial Agents and Chemotherapy, Laura Puzniak, PhD, MPH, and colleagues, including CIDRAP-ASP Advisory Committee member Arjun Srinivasan, MD, describe an antimicrobial susceptibility analysis of 11,701 Pseudomonas aeruginosa blood and respiratory isolates collected from 304 US hospitals from October 2016 to September 2017, finding that commonly used antipseudomonal drugs do not achieve 95% coverage.

Jan 31, 2019 - In Electronic Component News, Tierney King, MBA, describes a partnership between the US Centers for Disease Control and Prevention and Hewlett-Packard to use technology to "print" antibiotics on which isolates can be tested for susceptibility

Jan 24, 2019 - In Expert Review of Molecular Diagnostics, Grégory Dubourg, PharmD, et al review diagnostic methodologies and susceptibility tests to quickly identify pathogens implicated in bloodstream infections, finding that post-culture tests such as matrix-assisted laser desorption ionization time-of-flight mass spectrometry were cost-effective when combined with antimicrobial stewardship policies and that, given their potential, further research may be needed to optimize next-generation sequencing methods on whole blood. 

Jan 24, 2019 - In Scientific Reports, Kelly Flentie, PhD, et al assess the use of an antimicrobial susceptibility test based on signal amplification of bacterial surfaces that enables phenotypic results within 5 hours.

Jan 24, 2019 - In Infection and Drug Resistance, Ing-Moi Hii, MD, et al used the 2012 revised Clinical and Laboratory Standards Institute (CLSI) breakpoints to assess the susceptibilities of non-albicans candidemia in patients treated in one of five Taiwanese hospitals from 2011 to 2014, finding an increase in Candida resistance and non-susceptibility rates, particularly for C tropicalis and C glabrata.

Jan 24, 2019 - In Current Opinion in Infectious Diseases, Angela Branche, MD, et al assess recent studies to describe the benefits and limitations of using procalcitonin to guide recognition of bacterial infection, severity assessment, and therapeutic decisions.

Jan 17, 2019 - The Foundation for Innovative New Diagnostics (FIND) extended the deadline of its call for partners to join the AMR Diagnostics Use Accelerator to improve the care of children and adolescents presenting with acute febrile illness in low- and middle-income countries until Jan 28.

Jan 17, 2019 - In Diagnostic Microbiology and Infectious Disease, Olivia Ellis, PhD, MS, MPH, et al describe how, in the absence of a commercially available rapid test for N gonorrhoeae antimicrobial susceptibility, a real-time polymerase chain reaction assay was validated as concordant with expected results, with an interpretable genotype yielded from 57.2% of 1,370 asymptomatic patients, 480 of whom could potentially be treated with ciprofloxacin.

Jan 17, 2019 - On the University of Nebraska Medical Center Division of Infectious Diseases blog, Raj Karnatak, MBBS, summarizes discussions from a recent journal club that focused on the strengths and weaknesses of a novel assay for the early diagnosis of sepsis.

Jan 17, 2019 - The European Centre for Disease Prevention and Control published an expert consensus protocol on colistin resistance detection and characterization for the European genomic surveillance of carbapenem- and colistin-resistant Enterobacteriaceae survey.

Jan 10, 2019 - The Longitude Prize blog summarizes the 2-day Accelerator Programme, which aimed to help 21 teams working across India build plans to bring to market their rapid diagnostic tests to reduce antimicrobial resistance.

Jan 10, 2019 - In Clinical Microbiology and Infection, Olivia Neeser, MD, et al assess the use of procalcitonin testing in different medical settings and patient populations.

Jan 3, 2019 - On the blog of the Longitude Prize, Christine Carson, PhD, discusses how a lack of consensus on the measurement of antimicrobial-resistant infections, inconsistent diagnostic coding, and variable susceptibility testing methods have led to difficulty in quantifying the scale of antimicrobial resistance.

Jan 3, 2019 - The most recent issue of the African Journal of Laboratory Medicine highlights the work of African laboratories in antimicrobial resistance surveillance, with perspectives from Samuel Kariuki, PhD, MSc, et al on a surveillance roadmap for the future; Yogandree Ramsamy, MBChB, MMed, et al on 5-year trends of ESKAPE pathogens in South Africa; Ashika Singh-Moodley, MMedSc, BMedSc, PhD, et al on drug-resistant healthcare-associated infections in South Africa; Yahaya Mohammed, MBBS, et al on antimicrobial-resistant cholera in sub-Saharan Africa; Hajo Grundmann, DrMed, PhD, MSc, and Hellen Gelband, MHS, on the potential for whole-genome sequencing as an integral part of surveillance; Natasha M. Gous, PhD, et al on the role of connected diagnostics; Rajiha A. Ibrahim, MSc, et al on the implementation of antimicrobial resistance surveillance in Ethiopia; Japheth A. Opintan, PhD, MPhil, on building financial support for Ghana's National Action Plan; and much more.

Dec 20, 2018 - The World Health Organization's Global Antimicrobial Resistance Surveillance System released a technical note on methods for the detection and surveillance of colistin resistance.

Dec 20, 2018 - In the Tohoku Journal of Experimental Medicine, Daisuke Hayashi, MD, et al describe how rapid reporting of polymerase chain reaction (PCR) results for suspected Mycoplasma pneumoniae in children at a Japanese hospital was associated with improvement in antibiotic prescribing for atypical pathogens

Dec 20, 2018 - In Open Forum Infectious Diseases, Andrew S. Tseng, MD, et al found in a study of 203 adults with positive blood cultures at the Mayo Clinic in Arizona that use of a rapid PCR-based blood culture identification panel significantly reduced the time to identification for both gram-positive and gram-negative bloodstream infections, though it did not reduce the time to antibiotic escalation or de-escalation.

Dec 20, 2018 - In Infectious Disease Special Edition, Lynne Peeples, MA, MS, highlights a poster on the implementation of rapid diagnostics and a telemedicine program offering 24-hour access to infectious disease physicians at a Kentucky hospital presented by Ashleigh Mouser, PharmD, at the American Society of Health-System Pharmacists Midyear Clinical Meeting.

Dec 13, 2018 - Registration is open for the 5th McGill Summer Institute in Infectious Diseases & Global Health, in Montréal, in June 2019, which will feature courses on antimicrobial resistance, global health diagnostics, and qualitative methods in global infectious diseases research, among other topics.

Dec 6, 2018 - The December issue of the Society for Applied Microbiology's Microbiologist magazine features numerous articles on the integration of antimicrobial stewardship into global public health efforts and insights into building capacity for rapid diagnostics and laboratory development in low-resource areas.

Dec 6, 2018 - In the African Journal of Laboratory Medicine, Iruka N. Okeke, PhD, MSc, discusses opportunities to build laboratory capacity and integrate molecular diagnostic methods in African healthcare settings.

Dec 6, 2018 - The Stop TB Partnership features an article about the work of Humana People to People Congo to use door-to-door visits and community health workers to access microscopy-based diagnosis of tuberculosis in the Ruashi mining area of the Democratic Republic of the Congo.

Dec 6, 2018 - In BMC Medicine, Alimuddin Zumla, MBChB, PhD, MSc, and Ibrahim Abubaker, MBBS, PhD, MSc, discuss the need for accurate data on and accessible diagnostic and health services for multidrug-resistant tuberculosis in refugees and migrants.

Dec 6, 2018 - On Contagion, Maureen Spencer, RN, MEd, describes the effect of rapid molecular diagnostics on time to optimal therapy for Clostridioides difficile infection and infections causing sepsis.

Dec 6, 2018 - In The Telegraph, Anne Gulland, MA, reports on diagnostic and susceptibility tests currently in development to identify pathogens causing urinary tract infections.

Dec 6, 2018 - In Wired, Maryn McKenna, MSJ, describes why antimicrobial resistance may threaten the availability of inexpensive and accessible testing for sexually transmitted diseases.

Nov 15, 2018 - In honor of World Antibiotic Awareness Week, Mediaplanet's Global Cause website features numerous interviews and in-depth profiles of individuals and projects working to implement antimicrobial stewardship in the government, healthcare, laboratory, research and development, and One Health sectors.

Nov 15, 2018 - In the Journal of Antimicrobial Chemotherapy, Athanasios Tsakris, MD, PhD, et al perform a Monte Carlo simulation in support of advocating for re-evaluation of current minocycline susceptibility breakpoints to inform the selection of appropriate therapy for multidrug-resistant Acinetobacterinfections.

Nov 15, 2018 - A blog post for the Virginia Commonwealth University School of Pharmacy describes a faculty-led antibiotic stewardship project targeting urinary tract infection prescribing and antibiogram development in a free clinic.

Nov 8, 2018 - In Clinics in Chest Medicine, Sarah Sungurlu, DO, and Robert A. Balk, MD, review situations in which biomarkers can be used with clinical judgment to guide antibiotic management and duration of therapy for pneumonia.

Nov 8, 2018 - In the International Journal of Antimicrobial Agents, Robert J. van de Peppel, MSc, et al modeled polymerase chain reaction (PCR)–based diagnostics and empirical therapy choices based on epidemiologic data of triazole resistance in invasive aspergillosis, finding that the implementation of PCR testing was projected to result in treatment-susceptibility mismatches of less than 5% when modeled against a triazole resistance rate up to 20%.

Nov 8, 2018 - In the American Journal of Infection Control, Salma Abbas, MBBS, MPH, et al describe low acceptance of pharmacist recommendations to de-escalate antibiotic therapy based on notification of rapid respiratory panel test results in a Virginia hospital.

Nov 1, 2018 - In a video for Healio, CIDRAP-ASP Advisory Committee member Debra A. Goff, PharmD, describes how hospital antimicrobial stewardship team members can advocate for rapid diagnostics.

Nov 1, 2018 - On preprint server bioRxiv, David McAdams, PhD, MS, et al evaluate the use of epidemiologic theory and data to assess the potential of rapid point-of-care diagnostics as a means to limit or reverse selection for antimicrobial resistance.

Nov 1, 2018 - In Clinical Pediatrics, Chelsea Zhu et al found that respiratory pathogen panel testing was associated with fewer antibiotic days of therapy and shorter hospital stays for children with a positive viral test at an Ohio children's hospital, while testing for children visiting the emergency department was associated with fewer antibiotic prescriptions at discharge.

Nov 1, 2018 - In a video for Healio, Cornelius (Neil) J. Clancy, MD, discusses how clinicians can adapt to using and interpreting non-culture–based rapid diagnostics for improved patient care.

Nov 1, 2018 - In Clinical Infectious Diseases, Marc A. Meier et al evaluate 13 studies of procalcitonin-guided antibiotic management in patients with positive blood cultures, finding that use of the biomarker was associated with lower antibiotic exposure without an apparent increase in mortality.

Nov 1, 2018 - In Antimicrobial Agents and Chemotherapy, Pranita D. Tamma, MD, MHS, et al found that the use of whole-genome sequencing on 40 Klebsiella pneumoniae clinical isolates could shorten the time to effective antimicrobial therapy by 20 hours when using real-time identification of acquired carbapenem resistance and by 26 hours with an assembly-based approach that identifies chromosomal mutations as well as acquired genes. 

Oct 25, 2018 - In Antimicrobial Agents and Chemotherapy, Allison M. Porter, PharmD, et al describe how use of multiplex polymerase chain reaction testing and pharmacist-led protocol for reporting blood culture results increased time in change to optimal antimicrobial therapy and decreased vancomycin use when appropriate in a small hospital in the state of Georgia.

Oct 18, 2018 - On Contagion, Michaela Fleming interviews Melvin Weinstein, MD, about existing and emerging diagnostic technology for bloodstream infections.

Oct 18, 2018 - In Infectious Disease Special Edition, Tom Rosenthal, MD, describes research on a new rapid and highly sensitive assay for Clostridioides difficile presented at IDWeek 2018.

Oct 18, 2018 - On Contagion, Nicola M. Parry, BVSc, MSc, interviews several clinicians about improving antimicrobial stewardship and interventions informed by the microbiology laboratory in the management of severe lower respiratory tract infections

Oct 18, 2018 - On the University of Nebraska Medical Center Division of Infectious Diseases blog, Jasmine Riviere Marcelin, MD, discusses de-escalation of empirical antimicrobial therapy and the role of the microbiology laboratory, with particular attention to the diagnosis and treatment of pneumonia. 

Oct 18, 2018 - In Antimicrobial Agents and Chemotherapy, Philip W. Lam, MD, BScPhm, found in a review of 428 patients with bacteremic urinary tract infections that urine culture susceptibility results predicted blood culture results and may be helpful in targeting antibiotic therapy and reducing broad-spectrum drug use.

Oct 18, 2018 - During a high-level visit to the Mycetoma Research Centre (MRC) in Sudan, Tedros Adhanom Ghebreyesus, PhD, MSc, World Health Organization (WHO) director-general, pledged the WHO's commitment to work with the MRC in developing better diagnostics, treatment, and prevention tools for mycetoma, an infectious disease caused by bacteria or fungi that mostly affects the feet of young manual workers, laborers, and herdsmen in developing countries. 

Oct 11, 2018 - In Clinical Infectious Diseases, Pui-Ying Iroh Tam, MB BCh, DMed, et al analyze 89,643 pediatric blood cultures collected at a Malawi hospital from 1998 to 2017, noting that while the incidence of bloodstream infections has decreased over the past two decades, resistance of gram-negative pathogens to first-line antimicrobials has increased from 7.0% to 67.7% in infants 60 days and younger.

Oct 11, 2018 - On the blog of the Longitude Prize, Ruth Neale, MSc, and Shannon Harmon, MSc, describe an event that asked participants to learn about and design a diagnostic test for antibiotic resistance through the medium of arts and crafts.

Oct 11, 2018 - In the Journal of Antimicrobial Chemotherapy, Maryza Graham, MBBS, et al evaluate survey responses related to antimicrobial reporting for blood and urine cultures from 94 Australian and New Zealand laboratories, finding that 82% of labs over-reported or inappropriately reported at least one antimicrobial and that 10 labs reported antimicrobials considered inappropriate for bacteremia on blood culture isolates.

Oct 11, 2018 - In Clinical Infectious Diseases, Sarah S. Romano, MPH, et al evaluate a case series of 13 men with Mycoplasma genitalium infection in the state of Washington, noting a high prevalence of macrolide resistance and long-lasting infections after azithromycin therapy, highlighting the need for therapy guided by diagnostic testing for men who have nongonococcal urethritis.

Oct 11, 2018 - In the Journal of Antimicrobial Chemotherapy, Mary Claire O'Grady et al examine the suitability of Irish empirical therapy guidelines related to the susceptibility of Enterobacteriaceae causing urinary tract infections (UTIs) over 6 months in the Cork region, noting that only nitrofurantoin had a resistance rate of less than 20%, commonly prescribed antimicrobials may be unsuitable in many cases, and treatment for UTIs should be guided by laboratory tests.

Oct 4, 2018 - The Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) announced that, in December, it will open a transnational call to JPIAMR member countries and eligible countries in Asia and Africa for proposals for innovative research projects on new or improved diagnostics and surveillance strategies. Pre-proposals will be due in February 2019.

Oct 4, 2018 - Vikor Scientific and Sanford Guide announced the release of an integrated product that combines advanced molecular diagnostics with infectious disease treatment guidelines to enable patient-specific treatment plans.

Oct 4, 2018 - In the Journal of Antimicrobial Chemotherapy, Riina Rautemaa-Richardson, DDS, PhD, et al highlight the development of a biomarker-based invasive candidosis guideline by a UK hospital antifungal stewardship team, noting that the guideline and program were associated with a 90% reduction in inappropriate antifungal initiation and a 58% reduction in mortality due to invasive candidosis in the intensive care unit.

Oct 4, 2018 - In Infectious Disease Special Edition, Eric Wenzler, PharmD, reviews evidence and experience supporting the combination of rapid diagnostic testing and antimicrobial stewardship for optimizing care for patients with bacteremia.

Oct 4, 2018 - On the World Bank blog, Uzo Chukwuma, MPH, describes her realization that developing antimicrobial stewardship programs in Tanzania will require creative and collaborative strategies to boost diagnostic and surveillance capabilities while potentially integrating stewardship into existing programs (eg, malaria prevention).

Oct 4, 2018 - On the Choosing Wisely website, the American Society for Clinical Pathology posted a recommendation against performing procalcitonin testing without an established, evidence-based protocol

Oct 4, 2018 - On Healio, Leah Molloy, PharmD, discusses the utility of biomarkers as diagnostic tools and aids in guiding cessation of antibiotics for suspected sepsis.

Sep 27, 2018 - In an interview published by the ReAct Group, Gunturu Ravathi, MBBS, MD, describes the implications of the WHO's essential diagnostics list for addressing antimicrobial resistance in Kenya and other African countries.

Sep 27, 2018 - In Clinical Infectious Diseases, Scott R. Evans, PhD, MS, et al evaluate the use of rapid molecular diagnostic tests to identify susceptibility to newer beta-lactam/beta-lactamase inhibitor combination antibiotics in Pseudomonas aeruginosa isolates, finding that the platforms were able to detect susceptibility but had a lower ability to detect resistance. 

Sep 20, 2018 - On Nov 8, 4 All of Us—in coordination with the British Society for Antimicrobial Chemotherapy, NHS England, Antibiotic Guardian, and the British In Vitro Diagnostics Association—will host the 2018 Diagnostics Summit in London, with sessions slated to address the importance of diagnostics in infectious disease and antimicrobial stewardship.

Sep 20, 2018 - On the blog of the Longitude Prize, Shannon Harmon, MSc, interviews Cassandra Kelly-Cirino, PhD, about the challenges faced by developers of diagnostics tests for drug-resistant infections in low-resource settings.

Sep 20, 2018 - In Antimicrobial Agents and Chemotherapy, Helio S. Sader, MD, PhD, et al assess the antibiotic susceptibility of 1,909 Pseudomonas aeruginosa isolates collected from 70 US medical centers, finding that colistin, ceftazidime-avibactam, ceftolozane-tazobactam, tobramycin, and amikacin had the highest susceptibility rates, while piperacillin-tazobactam and meropenem were active against 77.5% and 76% of isolates, respectively.

Sep 20, 2018 - In the International Journal of Urology, Kyle A. Richards, MD, et al evaluated characteristics of urinalysis and urine microscopy conducted on samples from 2,764 patients at a Wisconsin hospital in order to inform implementation of a reflex urine culture program, noting that the program was then associated with a 60% reduction in urine culture rates over the first 3 months.

Sep 20, 2018 - In PLoS Medicine, Amitabh B. Suthar, PharmD, MPH, et al outline components to building national surveillance programs for antimicrobial resistance—including diagnostic algorithms and coverage, data management, laboratory systems and performance—drawn partly from the practice of tuberculosis surveillance in South Africa.

Sep 13, 2018 - On Contagion, Julie Ann Justo, PharmD, MS, describes the interplay between rapid diagnostics, prediction scores, and choices about empirical therapy in the decision-making process of an antimicrobial stewardship team. 

Sep 13, 2018 - In the Pharmaceutical Journal, Julia Robinson, MSc, describes recent statements affirming the importance and integration of rapid diagnostics in UK antimicrobial stewardship programs made by Dame Sally Davies, MBChB, MS, and Lord Jim O'Neill to a House of Commons committee inquiry into the problem of antimicrobial resistance.

Sep 13, 2018 - In news from the University of Alabama in Huntsville, Diana LaChance, MA, describes the research of Surangi Jayawardena, PhD, who is developing low-cost, point-of-care diagnostic techniques for tuberculosis and chlamydia.

Sep 13, 2018 - Last week, the Clinical and Laboratory Standards Institute's Subcommittee on Antimicrobial Susceptibility Testing published a rationale authored by Romney M. Humphries, PhD, on colistin breakpoints for Pseudomonas aeruginosa and Acinetobacter species. (NB: You must enter a name and email address to download the document.)

Sep 13, 2018 - On the Small Things Considered blog, Michael Schmidt, PhD, discusses the implications of research that may enable clinicians to obtain faster susceptibility results for uropathogens.

Sep 13, 2018 - In the European Journal of Clinical Microbiology & Infectious Diseases, Lien Cattoir, MD, MS, et al discuss a simulated integration of rapid molecular testing and matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometry for 158 positive blood cultures at a Belgian hospital, finding that the use of these methods would necessitate rapid communication to adapt antimicrobial therapy in about one-third of patients.

Sep 6, 2018 - On Sep 12 and 13, LabRoots will hold a free Microbiology and Immunology Virtual Event, which will bring together experts to discuss rapid diagnostics for infectious diseases, methods for antibiotic susceptibility testing, environmental and post-disaster concerns, and more.

Sep 6, 2018 - In Diagnostic Microbiology and Infectious Disease, Haim Ben-Zvi, PhD, et al found that the introduction of a polymerase chain reaction test to diagnose staphylococcal bacteremia in an Israeli medical center was associated with significant improvements in antibiotic therapy, reductions in vancomycin use, and increases in beta-lactam use, with no significant effect on 30-day mortality rates.

Aug 30, 2018 - In the Cochrane Database of Systematic Reviews, Mikashmi Kohli, PhD, MSc, et al evaluate 66 studies, most of which took place in low- or middle-income countries, that assessed the diagnostic accuracy of a rapid nucleic acid amplification assay for extrapulmonary tuberculosis and rifampicin resistance, finding that test specificity was high and the test was accurate for determining rifampicin resistance, though the authors caution that treatment for presumed tuberculosis meningitis should be based on clinical judgment and not withheld over test results.

Aug 30, 2018 - In Antimicrobial Agents and Chemotherapy, Paige M. Bukowski, PharmD, et al evaluate the use of rapid diagnostic testing for 109 adult patients with blood cultures positive for gram-positive cocci in a Michigan community hospital where real-time antimicrobial stewardship team (AST) notification was not possible (ie, no weekend/evening AST services, clinical decision support software, or infectious disease consultant alerts of positive blood cultures), finding that the implementation of rapid diagnostic testing alone was associated with a significantly shorter median time to appropriate therapy and a reduced length of stay for patients with coagulase-negative staphylococci. 

Aug 30, 2018 - In Clinical Microbiology and Infection, Erlangga Yusuf, MD, PhD, MSc, and Raph L. Hamers, MD, PhD, review the components of the World Health Organization Model List of Essential In Vitro Diagnostics that are relevant to antimicrobial stewardship and clinical microbiology and discuss issues that should be considered for future versions of the list.

Aug 23, 2018 - In The Hospitalist, Bruce Jancin summarizes a presentation given by Kathryn Hendrickson, MD, at the annual meeting of the American College of Physicians, highlighting Dr. Hendrickson's research into the potential of rapid diagnostic testing for targeting antibiotic therapy and reducing drug overuse in patients hospitalized with community-acquired pneumonia.

Aug 23, 2018 - In Critical Care, Yannick Wirz, MD, et al conducted a patient-level meta-analysis of 11 randomized trials investigating the impact of procalcitonin-guided antibiotic therapy on mortality in intensive care unit patients, finding that procalcitonin-guided treatment was associated with earlier discontinuation of therapy and lower mortality even in patients with severe sepsis.

Aug 23, 2018 - In BMC Infectious Diseases, Gabor Fidler, MSc, et al evaluate the ability of a polymerase chain reaction to identify seven Candida species, finding that the assay may outperform conventional phenotypic diagnostics by providing accurate results from blood and blood culture and reducing time to identification of isolates implicated in causing fungal bloodstream infections.

Aug 23, 2018 - On Wellcome's Open Research website, Tavpritesh Sethi, MBBS, PhD, et al discuss the use of Bayesian network artificial intelligence models for analyzing microbiologic and susceptibility data from an Indian pediatric intensive care unit and developing an interactive dashboard for data sharing and interpretation. (NB: The authors have made their dashboard software and source code publicly accessible on GitHub.)

Aug 16, 2018 - On Contagion, Elizabeth Hirsch, PharmD, highlights new and revised breakpoints for ceftaroline, daptomycin, ciprofloxacin, levofloxacin, cefiderocol, and meropenem-vaborbactamapproved by the Clinical and Laboratory Standards Institute's Subcommittee on Antimicrobial Susceptibility and subject to official approval in January 2019.

Aug 16, 2018 - In Clinical Microbiology and Infection, Pedro Puerta-Alcalde, MD, et al evaluate time to positivity of blood cultures taken from patients with febrile neutropenia in a Spanish hospital, finding that multidrug-resistant gram-negative bacteria were documented in 14.8% of 850 bloodstream infection episodes, and that 92.1% of blood cultures were positive within 24 hours, which the authors say supports reassessing empirical therapy at 24 hours to consider applying de-escalation strategies.

Aug 16, 2018 - The British Society for Microbial Technology posted presentations on optimizing recovery of bacteria from blood cultures, tracking Staphylococcus aureus in the intensive care unit, metagenomic diagnosis of hospital-acquired pneumonia, using rapid diagnostics to inform antibiotic choice, and more from its recent "Rapid Diagnostics—Time is Relative" conference.

Aug 16, 2018 - In BMC Infectious Diseases, Yong Duk Jeon, MD, et al assess the use of matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) on isolates from patients with bacteremia and fungemia in a Korean hospital lacking an antimicrobial stewardship program (ASP), finding that the use of MALDI-TOF MS reduced the time to pathogen identification but had no effect on clinical outcomes or time to effective therapy. The authors conclude that an "ASP combined with MALDI-TOF MS is necessary to improve clinical outcomes."

Aug 16, 2018 - In ACP Hospitalist, Mollie Durkin provides perspectives from numerous US clinicians about the arguments surrounding use of procalcitonin testing for antimicrobial stewardship and the biomarker's utility as a tool for driving improved antibiotic prescribing.

Aug 9, 2018 - The World Federation of Public Health Associations posted recordings of lectures given at the May International Global Health & Antimicrobial Resistance Workshop. Videos feature presentations on the importance of prevention, education, and diagnostics in addressing antimicrobial resistance, the need for cooperation in improving the accessibility and affordability of drug developmentGhana's progress on the National Action Planglobal political and behavioral aspects to stewardship, and the importance of a One Health approach.

Aug 9, 2018 - In Diagnostic Microbiology and Infectious Disease, Belen Gutierrez-Gutierrez, MD, PhD, et al found that the combination of a SOFA (sequential organ failure assessment) score and a decrease in procalcitonin or C-reactive protein levels between the first and second days after blood culture in patients with bacteremia due to gram-negative bacteria in a Spanish hospital were predictors of early clinical stability on day 3, which was associated with lower 30-day mortality.

Aug 9, 2018 - In the Journal of Infection, Stefanie Kampmeier, DrMed, et al discuss the implementation of personal microbiological consultations for patients with Staphylococcus aureus bloodstream infections in a German hospital, finding that quick consultations improved adherence to antibiotic quality-of-care indicators even with a robust antimicrobial stewardship program.

Aug 9, 2018 - T2 Biosystems will host a Sep 18 webinar on "Sepsis Management: The Emergence of Rapid Diagnostics in the ED," featuring a presentation by Frank Peacock, MD.

Aug 2, 2018 - Luminex Corporation posted the recording of the recent webinar "Rapid Diagnostic Testing of Positive Blood Cultures & Impact on Antimicrobial Stewardship," presented by Brad Crane, PharmD, to discuss the implementation of rapid testing at a Tennessee hospital.

Jul 26, 2018 - In Infection Control & Hospital Epidemiology, Alicia Shugart, MA, et al found that only half of 4,685 microbiology laboratories in US acute care hospitals tested Enterobacteriaceae for carbapenemases in 2016, and though 1,885 (40%) of labs tested gram-negative bacilli for polymyxin susceptibility, only 63 (3%) used broth microdilution.

Jul 26, 2018 - In Scientific American, Helen Branswell discusses the interplay between development of rapid point-of-care diagnostics and the potential need for gonorrhea treatments that are tailored to increasing levels of antibiotic resistance.

Jul 19, 2018 - A new nonprofit and publicly supported initiative—the Antibiotic Resistance Monitoring, Analysis and Diagnostics Alliance (ARMADA)—launched with the intent to combine global collection of bacterial isolates and data that will inform development of surveillance measures and diagnostic tests.

Jul 19, 2018 Medical Clinics recently published articles on the roles of pharmacoeconomics, clinical microbiology, technology, metrics, and rapid diagnostics in antimicrobial stewardship programsin a special section edited by Cheston B. Cunha, MD.

Jul 19, 2018 - In Infection Control & Hospital Epidemiology, Jennifer L. Cole, PharmD, reports on the first year of procalcitonin assay implementation as part of an Arkansas Veterans Affairs antimicrobial stewardship program, questioning whether marginal decreases in antibiotic use associated with the biomarker test can justify its cost.

Jul 19, 2018 - On the American Society for Microbiology Bugs & Drugs blog, Matthew Pettengill, PhD, summarizes presentations on diagnostics for fungal infections, pediatric diagnostics, opportunities for the use of big data in infectious disease diagnostics, balancing the benefits and risks of multiplex testing, and more that took place at the recent Clinical Microbiology Open conference.

Jul 12, 2018 - In the American Journal of Health-System Pharmacy, Eric Wenzler, PharmD, et al review the implementation of rapid molecular diagnostics for bloodstream infections, with particular attention to the needs of hospitals that may lack clinicians trained in infectious diseases or antimicrobial stewardship.

Jul 12, 2018 - In Diagnostic Microbiology and Infectious Disease, Megan E. Gray, MD, et al found that an intervention comprising implementation of rapid diagnostics plus telephone consultation with an infectious diseases fellow reduced time to appropriate therapy by more than 10 hours for patients with enterococcal bloodstream infections.

Jul 12, 2018 - In Clinical Infectious Diseases, Xiang-Sheng Chen, MD, PhD, et al propose a multifaceted intervention comprising surveillance, outcomes measurement, antibiotic stewardship, diagnostics, antimicrobial assessment, and population pharmacokinetics/pharmacodynamics for expanding interdisciplinary research on gonococcal resistance in China. 

Jul 12, 2018 - In the Journal of Biomedical Informatics, Antonio Morales, PhD, et al evaluate the efficacy of empirical antibiotic therapy using a novel decision support method to enhance the usefulness of regional antibiograms, finding that the efficacy of antibiotics recommended by the new method on 15,799 cultures and 356,404 susceptibility tests was significantly greater than the efficacy of the antibiotics actually administered.

Jul 12, 2018 - In MD Magazine, Ryan Shields, PharmD, MS, describes how the integration of rapid diagnostics may improve care and prescribing for patients with infections caused by carbapenem-resistant bacteria. And in the same magazine, Thomas Lodise, PharmD, PhD, discusses methods of classifying risk, interpreting susceptibility breakpoints, and establishing surveillance for multidrug-resistant pathogens.

Jul 5, 2018 - Registration is open for "Emergency Department, Lab, and Antimicrobial Stewardship: Connecting the Dots," a free Jul 18 webinar hosted by the American Hospital Association's Health Forum, which will feature presentations from Christopher D. Doern, PhD, Lindsey Nielsen, PhD, and Barb DeBaun, RN, MSN on closed blood collection to reduce false-positive results and vancomycin days of therapy. 

Jul 5, 2018 - In Chest, Allison K. Guitor and Gerard D. Wright, PhD, evaluate mechanisms of resistance in bacteria that commonly cause respiratory infections, providing an overview of the implications of surveillance and rapid diagnostics in targeting antibiotic discovery efforts and antimicrobial stewardship interventions.

Jul 5, 2018 - On the Reflections on Infection Prevention and Control blog, Jon Otter, PhD, summarizes discussions from a recent journal club focused on elucidating the role and usefulness of procalcitonin in antimicrobial stewardship.

Jul 5, 2018 - Hello SWFL describes how Lee Health in southwest Florida introduced new blood collection technology into emergency departments at four hospitals in order to reduce healthcare costs and unnecessary antibiotic use, noting that the technology has so far been associated with an 83% reduction in false-positive identification of bloodstream infection.

Jul 5, 2018 - In Current Infectious Disease Reports, Jennifer Emberger, MD, MPH, et al examine the current state of US antimicrobial stewardship programs, with an eye toward establishing an evidence base and metrics for evaluation, implementing rapid diagnostics and telehealth capabilities, enhancing the role of bedside nurses, addressing alternatives to stewardship interventions in resource-poor settings, and improving the use of antibiotic allergy testing.

Jun 28, 2018 - In Becker's Clinical Leadership & Infection Control, Mackenzie Bean summarizes a presentation on integration of rapid diagnostic and biomarker testing into a West Virginia antimicrobial stewardship program given by Kara W. Orwig, PharmD, at Premier's 2018 Breakthroughs Conference and Exhibition.

Jun 28, 2018 - In the Harvard Gazette, Alvin Powell, ALM, highlights presentations on diagnostics, big data, and antibiotic development given at the recent "Data-Powered Strategies to Counteract Antibiotic Resistance" symposium.

Jun 28, 2018 - In the Journal of Post-Acute and Long-Term Care Medicine, Maria-Stephanie A. Tolg, PharmD, et al describe approaches to developing clinically useful antibiograms in long-term care settings where low numbers of collected bacterial isolates highlight the need for alternative methods of tracking antibiotic susceptibility.

Jun 28, 2018 - In the Journal of Antimicrobial Chemotherapy, Maddalena Giannella, MD, PhD, et al found that use of a rapid fungal diagnostic panel on blood samples from 46 patients with severe sepsis or septic shock and risk factors for candidemia at an Italian medical center reduced the time to a negative Candida result by 5 days when compared with blood culture and that the method may be useful in reducing the duration of empirical antifungal therapy.

Jun 28, 2018 - In an interview with the Pew Charitable Trusts, Anthony Fauci, MD, discusses the threat of drug-resistant gram-negative infections, highlighting research being conducted and supported by the US National Institute of Allergy and Infectious Diseases to identify diagnostic and therapeutic innovations.

Jun 21, 2018 - In The Messenger, Hans Madsen describes the work of UnityPoint Health-Trinity Regional Medical Center in Iowa to integrate rapid diagnostic testing and infectious diseases consultation into its antimicrobial stewardship program. 

Jun 21, 2018 - The Febrile Illness Evaluation in a Broad Range of Endemicities (FIEBRE) study at the London School of Hygiene & Tropical Medicine aims to evaluate antibiotic susceptibility of bacterial causes of fever, local perceptions affecting treatment, the use of diagnostics and antimicrobials, and other issues affecting fever management in sub-Saharan African and Southeast Asian countries.

Jun 14, 2018 Infectious Disease Special Edition published a series of articles devoted to antimicrobial stewardship and resistance, including an overview by Paul P. Cook, MD, of clinical challenges posed by multidrug-resistant infections and management strategies; a discussion and series of interviews by Karen Blum, MS, on the utility and interpretation of antibiograms; and an in-depth look at the optimal use of rapid diagnostics in antimicrobial stewardship from Eric Wenzler, PharmD.

Jun 14, 2018 - On the blog of the Pneumonia Innovations Network, Debby Bogaert, MD, PhD, highlights the implications of low-cost microbiome-based diagnostic tools for children with pneumonia in low- and middle-income settings.

Jun 14, 2018 - In the European Journal of Clinical Microbiology & Infectious Diseases, Beatrice Demore, PharmD, et al describe an antimicrobial stewardship intervention involving integration of rapid antigen testing for adults with sore throat in 98 French pharmacies, finding that the program was associated with increased adherence to antibiotic prescribing guidelines.

May 31, 2018 - The Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) released a report and video interviews from its March meeting of researchers receiving JPIAMR funding to address surveillance in primary care, rapid diagnostic testing, One Health factors, and other key topics. 

May 31, 2018 - In the Concord Monitor, David Brooks describes a New Hampshire antimicrobial stewardship symposium for healthcare providers and veterinarians, with particular attention to the ongoing need to build awareness of regional susceptibility rates as they apply to treatment decisions.

May 24, 2018 - In the Annals of Medicine, Nathan I. Shapiro, MD, MPH, et al found in a multicenter study of 220 febrile patients with acute upper respiratory tract infections that a point-of-care biomarker test exhibited high sensitivity and specificity in identifying clinically significant bacterial infections

May 24, 2018 - Registration is open for a free Jun 20 Xtalks webinar on rapid diagnostic testing of positive blood cultures and its impact on antimicrobial stewardship with Brad Crane, PharmD. 

May 24, 2018 - In Clinical Infectious Diseases, Romney Humphries, PhD, et al describe the potential implications of the US 21st Century Cures Act in allowing developers of diagnostic and susceptibility tests to more rapidly update to current breakpoints.

May 24, 2018 - In Healthcare Purchasing News, Susan Cantrell interviews numerous clinicians, industry professionals, and policymakers about the implementation of antimicrobial stewardship in diverse settings, tactics for gathering and interpreting antimicrobial use data, measuring stewardship performance, and integrating appropriate blood culturing methods and notifications.

May 17, 2018 - The Longitude Prize launched a platform for users to identify global funding opportunities related to development of antimicrobial resistance diagnostics.

May 17, 2018 - In the Pediatric Infectious Disease Journal, Caroline H. Reuter, MD, et al found that implementation of matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) and multiplex polymerase chain reaction (mPCR) testing in a Chicago children's hospital reduced unnecessary antibiotic use and time to optimal antimicrobial therapy for children with positive blood cultures.

May 17, 2018 - On the Microbiology and Infectious Diseases Postgraduate Teaching blog, John Ferguson, MBBS, posted materials from presentations on antimicrobial stewardship and antibiotic susceptibility testing given to medical residents at Nepal's Bir Hospital. 

May 10, 2018 - In Clinical Chemistry and Laboratory Medicine, Juliane Hey, PharmD, et al conduct a meta-analysis of 11 trials of procalcitonin-guided antibiotic stewardship in adult patients with lower respiratory tract infections, finding that patients whose treatment was guided by procalcitonin had a lower odds of antibiotic initiation and a shorter mean antibiotic use with no adverse impact on mortality or length of hospital stay.

May 10, 2018 - The UK National Institute for Health and Care Excellence published a Medtech innovation briefing that assesses the implications of using point-of-care diagnostic testing for pharyngitis caused by Group A Streptococccus in primary care

May 3, 2018 - The Longitude Prize and India's Biotechnology Industry Research Assistance Council made a short film featuring stories about antibiotic resistance from India and insight into the development of rapid diagnostic tests. And in a blog post for the London Science Museum, Shannon Harmon, MSc, discusses the process and ideas behind the film's creation.

May 3, 2018 - In the Journal of the Pediatric Infectious Diseases Society, Robert R. Tanz, MD, et al discuss the significant rise in positive test results for pharyngeal infections caused by group A Streptococcus at a Chicago children's hospital after the microbiology laboratory replaced throat culture with rapid molecular testing, also questioning if the likely associated increase in antibiotic prescribing represents a benefit to patients in areas with low rates of acute rheumatic fever. In the same journal, Preeti Jaggi, MD, and Amy Leber, PhD, respond by asking if molecular assays may be too sensitive and thus counteract antimicrobial stewardship by increasing potentially unnecessary antimicrobial use.

May 3, 2018 - On Healio, Stephanie Viguers summaries research presented by Keith W. Hamilton, MD, at the Society for Healthcare Epidemiology of America spring conference on a collaboration between the Hospital of the University of Pennsylvania and ILÚM Health Solutions to develop a patient-specific antibiogram to inform antibiotic prescribing practices.

Apr 26, 2018 - In the Journal of Antimicrobial Chemotherapy, Stefano Mancini, PhD, et al describe software that allows visualization of antimicrobial susceptibility data along with the reliability of the categorization to enhance clinicians' ability to interpret an antibiogram.

Apr 26, 2018 - In Clinical Infectious Diseases, Hanine El Haddad, MD, et al review the available evidence concerning the role of procalcitonin and proadrenomedullin in guiding antimicrobial therapy for immunocompromised patients with sepsis or bloodstream infections

Apr 26, 2018 - In Intensive Care Medicine, Cedric Daubin, MD, et al found that the use of procalcitonin to guide an antibiotic protocol without antibiotic therapy at baseline in patients experiencing severe acute exacerbations of chronic obstructive pulmonary disease significantly increased 3-month mortality and failed to reduce antibiotic exposure in intensive care units in 11 French hospitals.

Apr 19, 2018 - In the American Journal of Infection Control, Charles E. Edmiston, PhD, et al describe available rapid diagnostics for bloodstream infections and their roles in antimicrobial stewardship programs.

Apr 19, 2018 - In Clinical Microbiology and Infection, Makeda Semret, MD, MSc, et al assess the use of rapid diagnostics, point-of-care and susceptibility testing, and laboratory networks to improve care and prescribing for febrile syndromes in low-resource settings.

Apr 19, 2018 - On the blog of the Longitude Prize, Rose Brade discusses the clinical barriers to using and interpreting rapid diagnostic and point-of-care testing.

Apr 19, 2018 - A press release from Monash University highlights funding recently awarded by the Australian government to a multidisciplinary team for the development of a rapid diagnostic test to directly detect bacterial and fungal causes of sepsis in whole blood

Apr 19, 2018 - On The Lancet United States of Health blog, Ray Cavanaugh discusses the growing need for robust antimicrobial stewardship programs and rapid diagnostic testing capability in US healthcare facilities.

Apr 19, 2018 - On the Association of Health Care Journalists Covering Health blog, Victoria Colliver, MA, describes insights into antimicrobial resistance, stewardship interventions, and drug and diagnostics development that were presented last week at the Health Journalism 2018 conference.

Apr 12, 2018 - A supplement to the Journal of Antimicrobial Chemotherapy explores the use of culture-independent diagnostics in medical mycology and multidrug-resistant gram-negative infections.

Apr 12, 2018 - In Expert Review of Anti-Infective Therapy, Matthew W. McCarthy, MD, and Thomas J. Walsh, MD, propose strategies to improve collaborations between hospitalists and infectious disease specialists to bolster the integration of emerging diagnostics, novel antimicrobial agents, and antimicrobial stewardship.

Apr 12, 2018 - On IDStewardship, Timothy P. Gauthier, PharmD, and Julie Ann Justo, PharmD, MS, list five things antibiotic stewards should know about a hospital antibiogram.

Apr 12, 2018 - On The Pig Site, Amanda Beaudoin, DVM, describes the importance of diagnostics, reporting, biosecurity, vaccination, and quality assurance in antimicrobial stewardship for pork production

Apr 5, 2018 - In Infectious Disease Special Edition, Kate O'Rourke, MA, interviews Katherine Perez, PharmD, about the use of rapid diagnostic and biomarker testing in antimicrobial stewardship at Houston Methodist Hospital.

Apr 5, 2018 - In the Journal of Antimicrobial Chemotherapy, Megan E. Patch, PharmD, MS, et al found that implementation of a rapid diagnostic Candida panel in a Florida community health system was associated with a significant decrease in time to appropriate therapy and an avoidance of empirical antifungal therapy in almost 60% of patients with negative test results. 

Apr 5, 2018 - In Infectious Diseases, Assaf Mizrahi, PharmD, et al found that use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in a French hospital yielded an accurate identification for 89.8% of 335 blood cultures and led to early antibiotic therapy adaptation in 73 bloodstream infection episodes.

Apr 5, 2018 - MediaPlanet launched a Global Cause communications campaign on antibiotic resistance, featuring perspectives on interdisciplinary UK antimicrobial stewardship, integration of rapid diagnostics, and the environmental impact of antibiotic manufacture and use.

Apr 5, 2018  - The UK Clinical Pharmacy Association is offering a 1-day forum for pharmacists, "What the cell: Unlocking diagnostics, metrics and big data—the new era of stewardship," on Oct 5.

Apr 5, 2018 - In Pharmacotherapy, Elizabeth W. Covington, PharmD, et al review evidence supporting the use and interpretation of procalcitonin levels as an antimicrobial stewardship strategy.

Mar 29, 2018 - In Clinical Microbiology and Infectious Diseases, Susan K. Seo, MD, et al found that the combination of antimicrobial stewardship support and rapid identification of coagulase-negative staphylococci from positive blood cultures was associated with improved vancomycin avoidance and a shorter median antibiotic duration in patients treated at a New York tertiary cancer center.

Mar 29, 2018 - On SciDev.Net, Ochieng' Ogodo discusses the implications of antimicrobial resistance in sub-Saharan Africa, highlights data from Niger that demonstrate rising drug resistance and more complex bacterial infections, and advocates for availability of diagnostic testing and training programs for healthcare and veterinary professionals.

Mar 29, 2018 -  In Antimicrobial Resistance & Infection Control, Marie-Elisabeth Bougnoux, MD, PhD, et al summarize the characteristics of outbreaks caused over the past 6 years by uncommon or new fungal pathogens and the contributions of whole genome sequencing and rapid diagnostics to prompt outbreak investigation and intervention.

Mar 29, 2018 - On the University of Nebraska Medical Center (UNMC) blog, Jasmine Riviere Marcelin, MD, and Rajendra Karnatak, MBBS, describe the most recent UNMC Infectious Diseases Journal Club, which brought together clinicians to discuss the role of rapid molecular diagnostic testing in improving antimicrobial stewardship and patient outcomes for bloodstream infections.

Mar 29, 2018 - In Current Opinion in Infectious Diseases, Carolina Navarro-San Francisco, MD, et al review the potential impact of rapid diagnostics and susceptibility testing for clinical decision-making in people with complicated SSTIs and immunocompromised patients.

Mar 22, 2018 - On the American Society for Microbiology Bugs & Drugs blog, Matthew Pettingill, PhD, discusses the importance of rapid molecular testing of blood cultures and clinical microbiology staffing for antimicrobial stewardship and patient care

Mar 22, 2018 - In the Journal of Intensive Care Medicine, Maureen Campion, PharmD, and Gail Scully, MD, MPH, review the use of guidelines for empirical therapy, specimen collection and molecular diagnostics, antibiotic dosing optimization, and duration of appropriate therapy in the intensive care unit.

Mar 15, 2018 - In Clinical Infectious Diseases, Robin Patel, MD, and Ferric C. Fang, MD, discuss the role of diagnostic stewardship in the healthcare integration of microbial diagnostics and the need for close partnerships between clinical laboratories, pharmacists, and infectious disease clinicians.

Mar 15, 2018 - The Social Entrepreneurship to Spur Health (SESH) project is encouraging submissions to a contest for writing clinical cases on diagnostics and antimicrobial resistance for use in medical education

Mar 15, 2018 - In the British Journal of Hospital Medicine, Andrew N. Claxton, MBChB, MSc, and Paul M. Dark, MBChB, PhD, review the evidence for biomarker-guided antimicrobial discontinuation protocols in patients with sepsis.

Mar 15, 2018 - In the Journal of Clinical Microbiology, Siran Keske, MD, et al found that use of a rapid molecular gastrointestinal pathogen test in a Turkish hospital was associated with significant reductions in unnecessary antibiotic use, along with increased detection of pathogens that were difficult to isolate via routine stool culture.

Mar 15, 2018 In The Economic Times, Prabha Raghavan describes how India is expected to create an essential diagnostics list for public healthcare facilities, which is expected to curb inappropriate antibiotic use and improve the development and integration of new diagnostic tools at the local level. 

Mar 15, 2018 - The monthly journal club hosted by Australia's National Centre for Antimicrobial Stewardship will discuss nurse-led respiratory multiplex polymerase chain reaction test results to reduce antibiotic prescribing in long-term care settings and the feasibility of implementing surgical prophylaxis guidelines on Mar 21.

Mar 8, 2018 - In a special report for Financial Times, Andrew Jack describes the need for integration of rapid diagnostics to tailor treatment and distinguish between viral and bacterial infections with an emphasis on primary care settings in South Africa, noting that "the tests themselves will be of limited impact unless they can reach patients in poorer countries."

Mar 8, 2018 - In Recenti Progressi in Medicina, Silvia Forni, et al discuss the ongoing development of a Tuscan model to integrate rapid diagnostics and antimicrobial stewardship for the care of patients with sepsis.

Mar 8, 2018 - In The Lancet Infectious Diseases, Sien Ombelet, MD, et al recommend improving and adapting culture-based technologies, validating and adopting diagnostic technology when possible, and integrating microbiologic education relevant to interpreting diagnostic and susceptibility results as a means to address antimicrobial resistance in low-resource settings.

Mar 8, 2018 - The newest podcast from the Institute on Science for Global Policy ponders the balance between the potential to obtain comprehensive data on antimicrobial resistance from DNA sequencing technologies and the usefulness of applying such data within a clinical context.

Mar 8, 2018 - In BMC Infectious Diseases, Erik J. Groessl, PhD, et al describe how the implementation of rapid methods for diagnosing drug-resistant tuberculosis in India, Moldova, and South Africa reveals how a faster time to result must be weighed against the potential for reduced accuracy and increased costs.

Mar 8, 2018 - On Contagion, Peter L. Salgo, MD; Debra Goff, PharmD; Andrew Shorr, MD; Jason Pogue, PharmD; and Sandy J. Estrada Lopez, PharmD, discuss the practical details of using diagnostic tests for gram-negative nosocomial infections

Mar 1, 2018 - In Open Forum Infectious Diseases, Patrick Joseph, MD, and Eliot Godofsky, MD, reviewed the use of Myxovirus resistance protein A (MxA), C-reactive protein, and procalcitonin as biomarkers for distinguishing between viral and bacterial infections and differentiating bacterial upper respiratory infection from colonization, finding that the combination of MxA with other biomarkers could present a useful strategy for outpatient antibiotic stewardship.

Feb 15, 2018 - In the European Journal of Clinical Microbiology & Infectious Diseases, Debby Bogaert, MD, PhD, and Alex van Belkum, PhD, describe the potential of diagnostics and antimicrobial stewardship interventions oriented toward preserving the diversity of the human microbiome.

Feb 15, 2018 - In the Toronto Star, Leah Cowen, PhD, of the University of Toronto writes an opinion piece on the need for Canadian investment in research toward new antimicrobials, vaccines, and diagnostics to address antimicrobial resistance.

Feb 15, 2018 - On the American Society for Microbiology's Bugs and Drugs blog, Romney Humphries, PhD, discusses factors involved in interpreting intermediate susceptibility results and the implications of diagnostic uncertainty.

Feb 8, 2018 - In Der Anaesthesist, Daniel C. Richter, MD, et al describe the importance of appropriate empirical therapy, pharmacokinetic/pharmacodynamic–oriented approaches to antibiotic treatment, interdisciplinary antimicrobial stewardship team involvement, and the role of rapid diagnostic testing in reducing sepsis-related mortality.

Feb 8, 2018 - FIND reported on a meeting held in the Cape Town, South Africa, township of Khayelitsha to discuss the need for rapid diagnostics and diagnostic capabilities to tackle antimicrobial-resistant infections across the African continent. Last month, FIND published a strategy aimed toward accelerating diagnostics use to prevent antimicrobial resistance.

Feb 1, 2018 - In Critical Care, Thiago Lisboa, MD, et al review study data that support procalcitonin-guided antibiotic stewardship and questions that remain regarding the interpretation of biomarker data in patient care.

Jan 25, 2018 - In Urologia Internationalis, Jennifer Kranz, MD, et al discuss the 75 recommendations and 68 statements made by an interdisciplinary group to update German guidelines for managing complicated urinary tract infections in adults, reflect Germany's participation in the global antibiotic stewardship initiative, and offer clarity on diagnostic guidance. 

Jan 18, 2018 - In Infection Control & Hospital Epidemiology, Gregory R. Madden, MD, et al discuss the role of diagnostic stewardship in accurately identifying healthcare-associated infections and the implications for appropriate antimicrobial use.

Jan 18, 2018 - In the European Journal of Clinical Microbiology & Infectious Diseases, Siran Keske, MD, et al assess the antimicrobial stewardship value of rapid molecular testing for 1,317 patients with influenza-like illness presenting to an Istanbul hospital during 2015 and 2016, finding that rapid testing was associated with a significant decrease in antibiotic use in children and a significantly shorter duration of antibiotic use in both adults and children.

Jan 11, 2018 - In the Journal of Clinical Microbiology, Giovanni Roldan, MD, et al find in a literature review that Clostridium difficile infection (CDI) rates in low- and middle-income regions are similar to those in the United States and Europe, though clinicians in low-resource countries may not be as likely to consider CDI as a diagnosis. The authors recommend heightened attention to diagnostic access and improved antibiotic stewardship and infection control programs.

Jan 11, 2018 - In the most recent Open Forum Infectious Diseases podcast, Paul Sax, MD, and Rebeca Plank, MD, MPH, rank their favorite infectious disease diagnostic tests and converse about the clinical usefulness of blood cultures, rapid testing, and the Etest (formerly the Episilometer test) to determine appropriate antimicrobial use.

Jan 11, 2018 - In the Journal of Hospital Infection, Michael J. Weinbren, MD, et al found that a project to optimize the blood culture pathway in a UK hospital reduced time to identification of blood culture isolates to less than 12 hours with 50% of positive cultures containing Escherichia coli reported with susceptibilities in less than 24 hours.

Jan 4, 2018 - In Infectious Diseases and Therapy, Adam L. Hersh, MD, PhD, et al found that the geographic variability in antibiotic prescribing rates for acute respiratory tract infections across the United States was strongly associated with regional variation in diagnosis rate and diagnostic practices.

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