Dual-Use Research

Recent News

Oct 10, 2013

Scientists find new botulinum toxin, withhold genetic details

Discovery of the first new botulinum toxin in 40 years is coupled with withholding key data for security reasons.

Sep 26, 2013

Dutch court affirms limit on publishing H5N1 findings

The court upheld an export rule, but virologist Fouchier said the decision won't apply to H7N9 research.

Sep 06, 2013

Think tank sees big risks in flu gain-of-function research

A new assessment says that avian flu "gain of function" research poses a serious outbreak risk.

Aug 14, 2013

Study: Technique adds 'kill switch' to modified flu viruses

A new molecular strategy could diffuse some of the controversy over lab-modified flu viruses.

Aug 07, 2013

Scientists air topics for H7N9 gain-of-function research

Will future research include lab-modified strains that are more transmissible and require tighter safety measures?

May 02, 2013

Study: Lab-made H5N1-H1N1 viruses spread in guinea pigs

(CIDRAP News) – Chinese scientists report that lab-generated hybrid viruses combining genes from avian H5N1 and pandemic 2009 H1N1 (pH1N1) influenza viruses can achieve airborne spread between guinea pigs, a finding that seems likely to renew the debate about the risks of creating novel viruses that might be able to spark a human pandemic.

May 01, 2013

WHO report: Global guidance on dual-use research needed

(CIDRAP News) – Participants in a World Health Organization (WHO) meeting held in February agreed that a binding global agreement to govern potentially dangerous life-sciences research is unlikely, but global guidance on the thorny issue could help nations figure out their own policies, according to a WHO report of the meeting.

Mar 29, 2013

Scientists seek ethics review of H5N1 gain-of-function research

(CIDRAP News) – A group of scientists acting under the aegis of a vaccine research advocacy organization has asked President Obama's bioethics committee to evaluate the ethics of experiments designed to increase the transmissibility of H5N1 avian influenza viruses.

Mar 26, 2013

GAO report reiterates biolab oversight gaps

(CIDRAP News) – The United States still lacks a way to assess the need for high-containment laboratories and national standards for building and maintaining them, despite 2009 recommendations, according to a report yesterday from the Government Accountability Office (GAO).

Resources & Literature

Recent Literature

Gronvall GK. H5N1: a case study for dual-use research. (Commentary) CFR 2013 (published online Jul 15)

Jaffe HW, Patterson AP, Lurie N. Avian flu: extra oversight for H7N9 experiments. (Letter) Nature 2013 Aug 8;500:151

Langlois RA, Albrecht RA, Kimble B, et al. MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies. Nat Biotechnol 2013 (published online Aug 11)

Nature Editors. Handle With Care. (Editorial) Nature 2013 Aug 8;500:121 

Taubenberger JK, Morens DM. Influenza viruses: breaking all the rules. (Commentary) mBio 2013 Jul 16;4(4):e00365-13

Thornburg NJ, Nannemann DP, Blum DL, et al. Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses. J Clin Invest2013 (published online Sep 3)

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