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CMS will boost payments for the use of new antibiotics and for treating patients who have drug-resistant infections.
More than 100 governments, drug firms, and others have already made commitments.
A list of critical-need antimicrobials would guide awards, which include incentives and responsibilities for companies, including stewardship reporting.
Since July 2012, the FDA has approved 12 products that are now on the market.
The US-UK partnership will provide $44 million this year and as much as $350 million over 5 years.
Feds say coordinated activities can save $1 billion a year.
Human and animal samples tested positive.
Highlights include funds for antibiotic resistance, bioterrorism preparedness, and a unified food safety agency.
The multipronged attack includes an executive order, a national strategy, and a detailed PCAST report.
HHS awarded $16.8 million to a Swiss company for a new antibiotic for melioidosis and glanders.
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