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Data show that about 4 of 1,000 seronegative patients vaccinated could develop ADE, a serious side effect.
A leading dengue vaccine researcher says the move is not surprising, while Sanofi says antibody-dependent enhancement cannot be the whole story surrounding vaccine performance.
The study highlights ADE, when previous virus exposure enhances disease response.
In the past, the city has experienced outbreaks of dengue, Zika, and chikungunya that were spread by Aedes aegypti mosquitoes.
The antibody protected both adult and fetal mice against Zika infection.
About 75% of counties on the US mainland have suitable habitat for Aedes mosquitoes, CDC researchers say.
The patients, hospitalized at a speciality center, had a variety of complications and some unusual features.
Also, the species might be resistant to cold temperatures.
The Florida study suggests a 'perfect storm' of conditions made Miami a favorable setting for Zika and that mosquito control helped reduce disease levels.
Vaccination led to 89% seroconversion against all 4 strains of dengue.
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CIDRAP - Center for Infectious Disease Research and PolicyOffice of the Vice President for Research, University of Minnesota, Minneapolis, MN
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