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In global developments, European officials warn of a growing gap in vaccine coverage, and the WHO certifies measles and rubella elimination in Bahrain, Oman, and Iran.
The WHO is stepping up its response in Europe, as cases surge in Tunisa and researchers plot at-risk US sites.
Though incidence is down, treatment success for resistant strains is low.
The ECDC reports 14,451 cases in 2017, up from 4,643 in 2016. Also, vaccination in Ghana is tied to higher childhood survival rates.
Half of EU nations report that only a third of older adults are vaccinated against flu.
Flu hospitalizations are also on the rise, with the highest levels in seniors, a pattern often seen in H3N2-dominant seasons.
Also, the CDC's travel notice said local officials are scaling up flea control and have cancelled mass gatherings.
The annual Muslim pilgrimage to Mecca begins on Wednesday.
In other developments, a few more cases were reported in the Americas and mosquito trials showed a risk of spread in major Kenyan cities.
The review didn't find any new evidence to drive policy changes, but said more research and new antivirals are needed.
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