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The CDC said it has also received recent reports of severe flu infections linked to 2009 H1N1 in young- and middle-aged adults.
The new Riyadh case bears similarities to several recent cases among a group of female roommates who work as janitors.
Two of four Jordan cases involve health workers, and contact info in a Riyadh case is being probed.
A case update from the WHO showed a variety of exposure types, with some unknown.
Medical coverage for the Hajj includes enlisting 25,000 extra health workers and 8 earmarked hospitals.
The 22 recent Saudi patients noted by the WHO include 8 health workers, and Jordan's outbreak involves 2 girls.
Medina cases are a worry, given the throngs of Hajj pilgrims visiting holy sites.
Also, a WHO roundup of 25 recent Saudi cases hints at the types of virus exposure some hospital patients had.
Saudi Arabia has had 18 MERS cases since Sep 4, 15 of them in Riyadh.
Also, Saudi officials reported four more cases from Riyadh, and South Korea announced new prevention steps in the wake of its outbreak.
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