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The number of people sickened in France's outbreak has grown from 2 to 13.
In other developments, a few more cases were reported in the Americas and mosquito trials showed a risk of spread in major Kenyan cities.
The cost study looked at different attack-rate ranges, putting the upper-end estimate at as much as $2 billion.
The man's infection is Spain's first that didn't involve travel to an endemic area.
Immune outcomes are promising, but the level of serious adverse events is a concern.
PAHO reports a large increase in the case count, driven largely by the Dominican Republic, and another locally acquired case is reported in Florida.
As PAHO stresses mosquito control and other steps, the US chikungunya total tops 900 cases.
About two thirds of the 38,000 new cases reported last week were in the Dominican Republic.
Cases in the Americas now total almost 475,000, with the Dominican Republic accounting for most of last week's rise.
The increase was led by the Dominican Republic, which had almost 60,000 new cases.
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CIDRAP - Center for Infectious Disease Research and PolicyOffice of the Vice President for Research, University of Minnesota, Minneapolis, MN
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