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The H5N8 virus continues to fuel outbreaks, including a first detection in Ireland.
The mutation "primed the pump" for bacteria to resist any antibiotic prescribed.
China has now confirmed 38 cases this season, compared with 10 at this point last season.
Flu is now widespread in 12 states, with a growing percentage of clinic visits for flu and hospitalization rates rising quickly for seniors, a group typically hit hard by H3N2.
The 128 cases in China and Hong Kong this season top last season's total of 118 infections.
More spread of H5N8 is occurring in Europe, with more nations reporting the virus in poultry.
The high-path strain that caused a huge outbreak in 2015 has been found in a Montana mallard.
Nearly a quarter of Shigella isolates in New York City showed decreased susceptibility or resistance.
In other Zika developments, the CDC released new fact sheets for pregnant women about the complexities involved in Zika testing.
Also, reports highlighted the first local US case and Zika in a man with a vasectomy.
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