News & Perspective

Nov 15, 2007

Nov 15, 2007

THE PANDEMIC VACCINE PUZZLE Can we vaccinate enough people in time to matter?

Maryn McKennaContributing Writer

(CIDRAP News) – This in-depth article investigates the prospects for development of vaccines to head off the threat of an influenza pandemic posed by the H5N1 avian influenza virus. Its seven parts put advances in vaccine technology in perspective by illuminating the formidable barriers to producing an effective and widely usable vaccine in a short time frame.

Nov 02, 2006

Nov 02, 2006

WHO report calls H5N1 vaccine stockpiling premature

(CIDRAP News) – A group of influenza experts convened by the World Health Organization cautioned today that governments shouldn't stockpile "pre-pandemic" H5N1 influenza vaccines now, because too little is known about the requirements for an effective vaccine.

Sep 11, 2006

Sep 11, 2006

Clinical study points to cytokine storm in H5N1 cases

(CIDRAP News) – A controlled study of H5N1 influenza patients in Vietnam has provided fresh evidence that explosive viral growth and the resulting cytokine storm, or excessive immune response, account for the often lethal nature of H5N1 disease.

Aug 18, 2006

Aug 18, 2006

WHO changes H5N1 strains for pandemic vaccines, raising concern over virus evolution

(CIDRAP News) – The World Health Organization (WHO) today changed the H5N1 avian influenza strains recommended for candidate vaccines for the first time since 2004, causing some experts to question how far the virus has evolved.

The WHO's new prototype strains, prepared by reverse genetics, include three new H5N1 subclades.

Jan 19, 2006

Jan 19, 2006

Second mutation in Turkey H5N1 virus suggests adaptation to humans

(CIDRAP News) – A new report in Nature cites more evidence that mutations detected in H5N1 avian influenza viruses recovered from patients in Turkey may better equip the viruses to infect humans.

Jan 10, 2006

Jan 10, 2006

Survey suggests avian flu cases may be going unnoticed

(CIDRAP News) – A survey conducted in Vietnam in 2004 suggests that human cases of avian influenza may be much more common but less severe than indicated by the numbers of confirmed cases, although the findings are not backed by laboratory testing.

Jan 05, 2006

Jan 05, 2006

YEAR-END REVIEW: Avian flu emerged as high-profile issue in 2005

Jan 6, 2006 (CIDRAP News) – 2005 is likely to go down as the year when avian influenza, powered by a steady rise in human cases and the spread of poultry outbreaks all the way to Eastern Europe, emerged as a high-profile global health issue.

When 2005 dawned, only 45 human cases of H5N1 avian flu, including 32 deaths, had been counted by the World Health Organization (WHO). All of those were in Vietnam and Thailand.

Jan 04, 2006

Jan 04, 2006

Turkey confirms its first human cases of avian flu

(CIDRAP News) – Turkey today confirmed two human cases of avian influenza, contradicting earlier statements and marking the disease's first attack on people outside East Asia, according to news reports this afternoon.

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