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As deaths top 1,000, a panel says it's ethical to use unlicensed drugs, vaccines.
In recent days, Guinea closed its borders, and suspected cases in Canada and Saudi Arabia were ruled out.
Along with the agency's declaration came an emergency committee's list of steps to limit disease spread.
An official of a leading aid group asserts that inaction by the rest of the world has let the disease get out of control.
With the situation in Nigeria worsening, CDC takes an action it last took during the 2009 H1N1 flu pandemic.
A US doctor with Ebola is improving and new cases have been reported in Morocco and Nigeria, as the outbreak reaches 1,603 cases and 887 deaths.
The illness continues to exact a heavy toll on healthcare workers and disrupt aid.
Two new developments are fanning concerns about the international spread of the disease.
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