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"Fighting Zika is the most complex epidemic response CDC has taken on," Frieden says.
Also, a review of blood samples suggests Zika-linked microcephaly in Hawaii as far back as 2009.
Texas reports another local Zika case as DNA vaccine is successful in phase 1 trial.
In other developments, research teams describe viral levels in semen and thrombocytopenia as a complication.
The data show different rates of defects but shed light on the link between exposure timing and poor outcomes.
All of Miami-Dade County is still a CDC cautionary area, and officials said more sporadic cases are likely.
The report adds to the growing body of literature linking Zika to a rise in microcephaly.
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