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"Fighting Zika is the most complex epidemic response CDC has taken on," Frieden says.
Other new reports detail co-infections with other mosquito-borne viruses and fatal encephalitis.
Cases in Puerto Rico topped 10,000, as more countries and regions reported local spread, microcephaly, and GBS.
The updates include an expanded definition of Zika congenital syndrome from PAHO and revised CDC guidance on testing pregnant women and on preventing sexual spread.
After a woman returned to the US from a Zika-affected area, a single act of intercourse likely transmitted the virus.
Defects can include craniofacial disproportion, spasticity, seizures, irritability, and eye problems.
In other developments, officials update guidance on sexual transmission and antibody testing.
Women in the sexually active age-group are much more likely than men to be infected with Zika virus.
Also, PAHO posts ethics guidance, and Colombia and Costa Rica note microcephaly.
Also, Chinese researchers noted more findings from infected fetal mice showing extensive damage in developing brains., and US funding efforts made some strides.
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