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"Fighting Zika is the most complex epidemic response CDC has taken on," Frieden says.
Florida said the Little River neighborhood is no longer an active site of Zika transmission.
Trinidad and Tobago as well as Vietnam report suspected Zika-linked microcephaly.
Also, a new study provides evidence for the usefulness of IgM Zika testing for babies.
Other new reports detail co-infections with other mosquito-borne viruses and fatal encephalitis.
Cases in Puerto Rico topped 10,000, as more countries and regions reported local spread, microcephaly, and GBS.
The updates include an expanded definition of Zika congenital syndrome from PAHO and revised CDC guidance on testing pregnant women and on preventing sexual spread.
After a woman returned to the US from a Zika-affected area, a single act of intercourse likely transmitted the virus.
Defects can include craniofacial disproportion, spasticity, seizures, irritability, and eye problems.
In other developments, officials update guidance on sexual transmission and antibody testing.
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