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Flu hospitalizations are also on the rise, with the highest levels in seniors, a pattern often seen in H3N2-dominant seasons.
The CDC said the H3N2-dominant trend will make neuraminidase inhibitor antivirals especially useful this flu season.
Clinic visits for flulike illness, geographic flu spread have accelerated.
Flu activity is widespread in 12 states, and the CDC reports a variant H3N2 case and a flu-related death in a child.
About 291,000 to 646,000 people in the world die from seasonal flu each year, experts estimate.
The number of states reporting geographically widespread flu rose from 4 to 7.
A meta-analysis finds 4 key differences between low-income and high-income nations involving children, pregnant women, and those with certain underlying medical conditions.
Flulike illness is high in 3 southern states, flu is widespread in 4 states, and one marker has topped the national baseline.
The agency reports increased activity overall, 5 pediatric deaths, and a variant H1N1 infection in Iowa.
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