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The April MERS surge continued, with 16 more cases reported in Saudi Arabia.
The Saudi count grows to 345, including 105 deaths, as a local medical conference is shelved.
Saudi Arabia reported 26 cases and Egypt its first, but new sequencing findings showed no major mutations.
As the WHO suggests a slight change in spread, the ECDC calls for higher concern.
Experts say possibilities include a change in the virus and a seasonal pattern to transmission.
The WHO offered investigation help, with 33 more infections reported in Saudi Arabia and UAE.
The Saudi MERS count surged by 37 cases and 6 deaths in 3 days, including 21 new cases in Jeddah's outbreak.
Seven cases were added to the Jeddah outbreak in Saudi Arabia, and 3 in the UAE.
The disease has made a long-feared leap outside the Middle East, killing a man in Malaysia and infecting a nurse in the Philippines.
A Jeddah outbreak increased by 5 cases, while the WHO reports 10 recent cases in UAE health workers.
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