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Scientists say it's the first MCR-1 hospital outbreak.
The findings are a sign the gene has spread widely in community and healthcare settings throughout the country.
Tonnage of fluoroquinolones, macrolides, and polymyxins for animals rose 14%, 13%, and 19%, respectively.
The case involved Caribbean travel and possible foodborne infection; also, officials note no spread in the first US case.
An E coli isolate resistant to both colistin and carbapenem antibiotics has been found in a US hospital patient.
Experts say resistance, though not a huge concern, is on the rise among pets.
One isolate was also resistant to beta-lactams, fluoroquinolones, and florfenicol.
The MCR-1 gene was most prevalent in poultry, with 10.7% of turkey isolates and 5.6% of broiler isolates testing positive.
Italian researchers, meanwhile, said they detected a variant of the MCR-1 gene.
Researchers discover a new gene distinct from MCR-1 that can confer colistin resistance and dub it MCR-2.
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