CIDRAP Antimicrobial Stewardship Project Newsletter – Mar 5, 2020


In this week's issue:

  • What's new at CIDRAP-ASP
  • Target product profiles for AMR diagnostics
  • Pan-TB drug development collaboration
  • Antibiotic manufacture and pollution in India
  • Invasive MRSA infections in patients living on White Mountain Apache Tribal lands
  • Stewardship in emergency and critical care for companion animals
  • Veterinary antibiotic use mapping on Indian poultry farms
  • UK antimicrobial guidelines for impetigo
  • Economic evaluation of penicillin allergy testing in the US and Europe
  • Neonatal chorioamnionitis antibiotic use intervention
  • Stewardship competency framework for nursing students
  • Microbiome approaches to AMR




[Weigh In] Take our March quiz to gauge your knowledge of antibiotics that are prescribed without a clear reason or with no doctor visit in the US. And to learn more, read a recent CIDRAP News story on an analysis of US Medicaid claims data on antibiotic prescribing over 10 years.


[Connect] On Contagion, CIDRAP-ASP Advisory Committee member Debra Goff, PharmD, describes a community outreach strategy that brought dentists and orthopedic surgeons together to find common ground on antimicrobial stewardship and prophylaxis.


[Read] CIDRAP News recently published stories on an EU report on rising resistance in common foodborne pathogens, a study linking frequent antibiotic use to a higher risk of hospitalization, a study tying acid suppressants to the risk of intestinal colonization with multidrug-resistant organisms, and much more.


[Research] Please take a moment to visit our recently launched compendium of databases and tools for antimicrobial resistance (AMR) surveillance, our antimicrobial stewardship diagnostics resources, our database containing hundreds of publicly available clinical tools for antimicrobial stewardship programs, and our educational multimedia page. The surveillance and diagnostics pages are updated at least weekly, and we add new clinical and educational tools monthly.


[Stay Current] We recently updated our AMR and antimicrobial stewardship bibliographies with 192 new resources. And if you'd like to stay current on all our news and events, please follow CIDRAP-ASP on Twitter and Facebook, subscribe to our YouTube channel, and subscribe to our antimicrobial stewardship podcasts on iTunes or Spotify.




[Register] On Mar 12 and Mar 18, the Society of Infectious Diseases Pharmacists Education Center will host a free webinar on "Emerging Practices in the Management of Community-Acquired Bacterial Pneumonia," featuring presentations from Michael S. Niederman, MD, and Alan Gross, PharmD. Participants will also be eligible for pharmacy, nursing, and medical continuing education credit.


[Evaluate] The World Health Organization published target product profiles for antibacterial resistance diagnostics, outlining minimal and optimal characteristics for multiplex platforms and tests to detect phenotypic susceptibility of prioritized bacterial pathogens.


[Analyze] The Bill and Melinda Gates Medical Research Institute announced the launch of the Project to Accelerate New Treatments for Tuberculosis (TB), a collaboration that aims to accelerate the development of novel pan-TB drug regimens that have little to no drug resistance and an acceptable safety profile, while also being better-tolerated, shorter in duration, and simpler to use than existing options.


[Rethink] Swedwatch, in collaboration with the Swedish Society for Nature Conservation, released a report on the community effects of pharmaceutical pollution in India, focusing extensively on antibiotic manufacture and calling for increased transparency and stricter environmental standards. And on the blog of the Stockholm International Water Institute (SIWI), Andrea Caputo, PhD, and Georgette Mrakadeh-Keane describe the relationship between antibiotic emissions in wastewater and the spread of AMR, highlighting the recent launch of a collaborative SIWI platform to take steps toward responsible antibiotic manufacture.


[Assess] In Open Forum Infectious Diseases, Catherine G. Sutcliffe, PhD, ScM, et al assess 53 cases of invasive Staphylococcus aureus infections in Native American patients living on the White Mountain Apache Tribal lands, finding that the community has a disproportionately high burden of morbidity, mortality, and antibiotic resistance, with 75.5% of infections caused by methicillin-resistant strains.


[Discover] On IDStewardship, Erin McCreary, PharmD, and Timothy P. Gauthier, PharmD, interview Ian DeStefano, DVM, about the implementation of antimicrobial stewardship in emergency and critical care for companion animals. And in The Hindu, Sidharth Yadav describes a movement by veterinarians to map and register poultry farms in India's Madhya Pradesh state as a way to track and reduce antibiotic overuse.


[Learn] The UK National Institute for Health and Care Excellence published guidelines that set out an antimicrobial prescribing strategy for adults, young people, and children age 72 hours and older with impetigo. And on the blog of the UK Microbiology Society, Marwa Hassan, BPharm, PhD, MSc, discusses mixing her love of science communication and research into biofilms and AMR in an interactive presentation at the British Science Festival.


[Examine] In Clinical Infectious Diseases, Bernardo Sousa-Pinto, MD, PhD, et al perform an economic evaluation of penicillin allergy testing for patients with a penicillin allergy label in the US and Europe, finding that testing was associated with average savings of $657 and $2,746 in inpatient and outpatient environments, respectively. And in the British Journal of Hospital Medicine, Joshua A. York, MBBS, et al review the benefits and risks of antibacterial combination therapy as it relates to coverage for specific infections, reducing the development of resistance, and immune modulation.


[Engage] On the Stanford Children's Health blog, Lynn Nichols, MA, describes a Stanford Children's Health intervention that allows well-appearing babies born to mothers with chorioamnionitis to stay with their parents and be monitored carefully instead of receiving automatic antibiotic therapy in the neonatal intensive care unit. And Michigan Medicine profiles Daniel Giesler, MD, PharmD, about the "Reducing Overuse of Antibiotics at Discharge (ROAD) Home" project and Giesler's journey from critical care pharmacy to internal medicine.


[Study] On Contagion, Michaela Fleming describes research presented at the 2020 Transplantation and Cellular Therapy Meetings of the American Society for Transplantation and Cellular Therapy and the Center for International Blood and Marrow Transplant Research into the increased risk of disease progression among patients who have undergone allogeneic hematopoietic cell transplantation and have been exposed to antibiotics prior to a viral respiratory infection.


[Explore] In Nursing Standard, Molly Courtenay, PhD, MSc, and Jo McEwen, MS, describe an antimicrobial stewardship competency framework and case study for undergraduate nurse education.


[Peruse] Science|Business interviews the authors of a recent publication on fighting AMR by translating evolutionary principles into clinical reality, highlighting the authors' views on prioritizing antibiotic development and antimicrobial stewardship, incentives for antimicrobial research, microbiology literacy in the general public, and recommendations for policymakers.


[Review] In BMJ, Elizabeth Mahase, MSc, summarizes a lecture given by microbiome scientist Gregory Amos, PhD, on the coordination of multiple approaches—specifically vaccines, fecal microbiota transplantation, and bacteriophage therapy—to address AMR.

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