Antimicrobial Stewardship Program

Oct 01, 2001

Standard HIV drug used in Africa may spawn resistance to a first-line malaria drug

(CIDRAP News) – Researchers from the University of Maryland School of Medicine have reported laboratory evidence of Plasmodium falciparum cross-resistance between trimethoprim-sulfamethoxazole, one of the standard treatments for HIV patients in Africa, and sulfadoxine-pyrimethamine, the first-line antimalarial drug in parts of Africa.

Oct 18, 2001

S pneumoniae resistance to macrolides is now common, CDC says

(CIDRAP News) – Macrolide antibiotics, the mainstay of treatment for community-acquired pneumonia, are encountering increasing resistance from Streptococcus pneumoniae, the most common cause of the disease, according to a report in the Oct 17 issue of the Journal of the American Medical Association.

Jan 11, 2002

Five-state survey finds antibiotic-resistant enterococci in ground pork

(CIDRAP News) – A recent analysis of ground pork in grocery stores in five states showed that 4% of the samples contained enterococci with high-level resistance to gentamicin, an antibiotic used to treat enterococcal infections in humans. In addition, most Enterococcus faecium isolates were resistant to quinupristin-dalfopristin (Synercid), a streptogramin antibiotic used to treat infections caused by vancomycin-resistant E faecium.

Feb 11, 2002

Taiwan study shows spread of fluoroquinolone-resistant Salmonella from pigs to humans

(CIDRAP News) – A study from Taiwan shows a rapid increase in fluoroquinolone resistance in Salmonella enterica serotype choleraesuis in humans over the past 2 years and suggests that the resistant strain spread from pigs. The findings prompted the researchers to urge a ban on fluoroquinoline use in food animals.

Feb 25, 2002

FDA to hold hearing on plan to bar enrofloxacin use in poultry

(CIDRAP News) – Nearly a year and a half after the Food and Drug Administration (FDA) first proposed to stop the use of enrofloxacin (Baytril, a fluoroquinolone antibiotic) in poultry because of safety concerns, the agency says it plans to hold a public hearing on the proposal. The date of the hearing will be set at a prehearing conference on April 8.

Apr 09, 2002

Drug-resistant Salmonella strain has long tenure in United States

A multidrug-resistant strain of Salmonella that emerged as a common pathogen in the mid-1990s was present in the United States as early as 1985, according to a report from the CDC.

Apr 17, 2002

FDA ruling on enrofloxacin use in poultry is more than a year away

A ruling by the Food and Drug Administration on whether to stop the use of enrofloxacin in poultry because of concern about antimicrobial resistance is more than a year away, according to a hearing schedule laid out by an FDA official.

Apr 30, 2002

Researchers: Restrict farm use of antibiotics before, but not after, human bugs become resistant

Study using a new mathematical model suggests that continued farm use of antibiotics has little further effect once a resistant strain is established in humans.
May 03, 2002

Drug-resistant Salmonella infections linked with higher mortality

In a Danish study, patients who had infections with a common drug-resistant type of Salmonella enterica were more than twice as likely to die within 2 years as patients infected with drug-susceptible variants of the same strain.

May 10, 2002

Expert panel urges halt to nontherapeutic use of antibiotics on farms

(CIDRAP News) – A committee of experts convened by the Alliance for the Prudent Use of Antibiotics (APUA) says that antibiotics should not be used in agriculture except to treat sick animals and protect healthy animals threatened by disease in the herd or flock.

May 15, 2002

Quinolone resistance growing in common foodborne strain of Salmonella

The most common cause of foodborne Salmonella infections grew increasingly resistant to the quinolone nalidixic acid between 1995 and 2000, according to a study from Denmark.

May 23, 2002

Drug-resistant Salmonella Newport in dairy cattle is growing threat, CDC expert says

(CIDRAP News) – Data on recent salmonellosis outbreaks indicate that drug-resistant strains of Salmonella enterica serotype Newport are becoming increasingly common in dairy cattle and are causing a growing share of infections in humans, according to a foodborne disease expert with the Centers for Disease Control and Prevention (CDC).

Jul 02, 2002

Drug-resistant Salmonella Newport infections linked with eating ground beef

July 2, 2002 (CIDRAP News) – A recent series of 47 cases of salmonellosis in five states has linked an increasingly common multidrug-resistant strain of Salmonella enterica serotype Newport with ground beef, according to the Centers for Disease Control and Prevention (CDC).

Jul 03, 2002

Julie Gerberding named director of CDC

(CIDRAP News) – Confirming earlier unofficial reports, Health and Human Services (HHS) Secretary Tommy Thompson today named infectious disease expert Julie Gerberding, MD, MPH, as the new permanent director of the Centers for Disease Control and Prevention (CDC). She becomes the first woman to lead the agency.

Oct 27, 2003

FDA outlines how to gauge risk that animal drugs will spawn superbugs

Editor's note: This story was updated from its original form to include additional details about the FDA guidelines and comments from a pharmaceutical industry representative.

(CIDRAP News) – The Food and Drug Administration (FDA) has released a guide to help the drug industry assess the risk that antimicrobial drugs intended for use in food animals will spawn resistant bacteria that could ultimately harm human health.

Aug 31, 2004

Flu virus shows surprising resistance to oseltamivir

(CIDRAP News) – Influenza viruses in 18% of a group of Japanese children who were treated with oseltamivir (Tamiflu) developed resistance to the antiviral drug, which is viewed as one of the key defenses against pandemic influenza, according to a new report in The Lancet.

Apr 01, 2005

Drug-resistant bacteria linger on chicken, study finds

(CIDRAP News) – A study of antibiotic-resistant Campylobacter levels on retail chicken products suggests that the pathogen lingers in chickens long after antibiotic use among the birds is stopped.

Oct 14, 2005

Oseltamivir-resistant H5N1 virus isolated from Vietnamese girl

(CIDRAP News) – A report published today by scientists who isolated an H5N1 virus resistant to oseltamivir from a infected Vietnamese girl further fuels concern over preparedness for a potential and widely anticipated pandemic caused by the strain.

Dec 22, 2005

Tamiflu resistance in avian flu victims sparks concern

(CIDRAP News) – A new report says oseltamivir-resistant forms of H5N1 avian influenza virus were found in two Vietnamese girls who died of the infection, raising doubts about the antiviral drug that many countries are counting on to help protect them from a potential flu pandemic.

Jan 14, 2006

CDC: Resistance makes 2 older flu drugs ineffective

(CIDRAP News) – The dominant strain of influenza virus in the United States has unexpectedly turned highly resistant to the two older antiviral flu drugs in use, prompting federal health officials today to advise physicians to stop using them for the rest of this season.

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