Children diagnosed as having multisystem inflammatory syndrome in children (MIS-C) following COVID-19 infection are more likely to have new and lingering health conditions than those not diagnosed with MIS-C, according to study published last week in Pediatrics.
MIS-C, a rare but potentially deadly post-viral hyperinflammatory condition that often requires hospitalization, occurs in some children following COVID-19. While previous research indicated that some symptoms waned two years after infection, this new paper is the first to show that health complications can persist up to 4.5 years after COVID-19.
14-fold higher chance of heart disease
In the large retrospective cohort study, researchers from Albert Einstein College of Medicine examined the Montefiore Health System electronic health records of 173 children with MIS-C and 14,190 children without the condition. They compared the two groups’ health for up to 4.5 years after their COVID-19 diagnosis.
The broad multisystem risks underscore the need for structured follow-up of patients with MIS-C.
Having MIS-C contributed to children acquiring new chronic health conditions. These children experienced a nearly 14-fold higher chance of developing cardiovascular disease, including heart failure. Children who had MIS-C also were at an increased risk of high blood pressure; neurologic and psychological disorders such as stroke, depression, and anxiety; respiratory and gastrointestinal conditions; and chronic kidney disease and shock.
“The broad multisystem risks underscore the need for structured follow-up of patients with MIS-C,” the authors wrote. “Routine blood pressure monitoring is essential, given the markedly elevated risk of hypertension.”
In addition, the researchers recommend multidisciplinary follow-up for children who had MIS-C that incorporates screening for cardiovascular health, renal function, and neurologic and mental conditions.
“Long-term outcome patterns in our cohort showed a clear and persistent accumulation of multisystem morbidity among survivors of MIS-C compared to matched controls without MIS-C, with disparities widening steadily over 4.5 years,” the authors wrote.