Giving children antiviral drugs within the first two days of the onset of flu symptoms reduces their likelihood of hospitalization by 81%, a study published last week in Pediatrics finds.
“This protective effect remained robust among children aged 5 years or younger,” wrote the authors, led by scientists at Hsinchu Municipal MacKay Children’s Hospital in Taiwan.
Many kids with flu not given antivirals
Worldwide, flu sent about 870,000 children under 5 years old to the hospital each year from 2010 to 2020. In the United States, 6,000 to 25,000 children annually require a hospital stay to treat flu and related illnesses.
The time has come for antivirals to be used in children with influenza.
The researchers conducted a retrospective case-control study of the health data of 1,492 children, of which 1,206 (80.8%) received antiviral therapy within 48 hours of flu symptom onset, 269 (18.0%) received antivirals after 48 hours, and 17 (1.1%) did not receive antivirals. Those who received prompt antiviral treatment were 81% less likely to need hospital care.
“It is important to emphasize that early antiviral therapy should not be used in lieu of vaccination but rather as a supplement to vaccination, particularly in children younger than 6 months who are not eligible for influenza vaccination,” the authors said.
In an accompanying commentary, James Antoon, MD, PhD, MPH, and Kathryn Edwards MD, both of Vanderbilt University, noted that some pediatricians seem reluctant to use antivirals, adding that about 40% of high-risk pediatric flu patients go without them.
They urged more widespread use of the drugs. “The time has come for antivirals to be used in children with influenza,” they said. “With greater public hesitancy regarding vaccines, declining seasonal influenza vaccination rates, and recent influenza seasons with record pediatric deaths and hospitalizations, providers should strongly consider the use of antivirals in high-risk and hospitalized patients.”