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In the past, the city has experienced outbreaks of dengue, Zika, and chikungunya that were spread by Aedes aegypti mosquitoes.
About 75% of counties on the US mainland have suitable habitat for Aedes mosquitoes, CDC researchers say.
The patients, hospitalized at a speciality center, had a variety of complications and some unusual features.
The Florida study suggests a 'perfect storm' of conditions made Miami a favorable setting for Zika and that mosquito control helped reduce disease levels.
The cost study looked at different attack-rate ranges, putting the upper-end estimate at as much as $2 billion.
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CIDRAP - Center for Infectious Disease Research and PolicyOffice of the Vice President for Research, University of Minnesota, Minneapolis, MN
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