News & Perspective

Jan 6, 2006 (CIDRAP News) – 2005 is likely to go down as the year when avian influenza, powered by a steady rise in human cases and the spread of poultry outbreaks all the way to Eastern Europe, emerged as a high-profile global health issue.

When 2005 dawned, only 45 human cases of H5N1 avian flu, including 32 deaths, had been counted by the World Health Organization (WHO). All of those were in Vietnam and Thailand.

(CIDRAP News) – A second vaccine against human H5N1 influenza is being developed, US Health and Human Services (HHS) Secretary Mike Leavitt announced yesterday.

In a speech at an immunization conference, Leavitt announced that he has authorized the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC) to start work on a second vaccine, according to an Associated Press (AP) report published yesterday.

(CIDRAP News) – The World Health Organization (WHO) today changed the H5N1 avian influenza strains recommended for candidate vaccines for the first time since 2004, causing some experts to question how far the virus has evolved.

The WHO's new prototype strains, prepared by reverse genetics, include three new H5N1 subclades.

(CIDRAP News) – Low doses of a cell-based avian flu vaccine triggered a good immune response to the H5N1 avian influenza virus, according to preliminary results of a clinical trial by Baxter International of Deerfield, Ill., maker of the vaccine.

(CIDRAP News) – Antibodies gleaned from four Vietnamese patients who survived H5N1 avian influenza were used successfully to prevent and treat H5N1 infection in mice, suggesting that the same approach might be useful in humans, according to a recent report by an international team of researchers.

Maryn McKennaContributing Writer

(CIDRAP News) – This in-depth article investigates the prospects for development of vaccines to head off the threat of an influenza pandemic posed by the H5N1 avian influenza virus. Its seven parts put advances in vaccine technology in perspective by illuminating the formidable barriers to producing an effective and widely usable vaccine in a short time frame.

(CIDRAP News) – Disease experts and preparedness advocates reacted negatively today to comments by the head of the World Organization for Animal Health (OIE) suggesting that the risk of an influenza pandemic posed by the H5N1 avian flu virus is minimal.

(CIDRAP News) – A pharmaceutical company is reporting good results in the first clinical trial of an H5N1 avian influenza vaccine that uses a whole, killed H5N1 virus grown in cell culture—a combination of techniques that entails some risk but may boost immune response and shorten production time.