Denmark has eliminated congenital syphilis, despite an overall increase in the syphilis rate among Danish women of childbearing age.
The Scandinavian country achieved elimination status through a comprehensive prenatal screening program, according to new research published in Eurosurveillance, the journal of the European Center for Disease Prevention and Control (ECDC).
Congenital syphilis, caused by the bacterium Treponima pallidum, is potentially life-threatening to babies or can cause severe birth defects. Pregnant patients receive Benzathine penicillin G to prevent transmission.
Several European countries have reported increases in congenital syphilis infections since 2015, but, as the study notes, Denmark has not had a single instance of a mother transmitting the disease, either during pregnancy or birth, to her baby since 2016.
"These results highlight the public health value of maintaining high screening coverage and robust surveillance, even in low-incidence countries," write the study's authors, led by Ulrik Lausten-Thomsen, MD, PhD, MSc, a neonatologist at Copenhagen University Hospital Rigshospitalet.
Continued surveillance is essential
From 2010 through 2024, researchers found just five cases of congenital syphilis among Danish-born babies.
Two of the babies were born to women who arrived in Denmark late during their pregnancies and were not screened for syphilis. Two others were attributed to maternal infections acquired late in pregnancy after a negative screening result.
The researchers said the only preventable case resulted from a reporting irregularity that delayed treatment. Following this incident, protocols were revised to prevent similar outcomes.
Of the 172 pregnancies with confirmed active syphilis infections that the study identified, 83 (48.3%) were among women of non-Danish origin. The researchers concluded that for Denmark to preserve its elimination status for congenital syphilis, continued surveillance is essential, including among vulnerable groups.