In Michigan, 113,000 birds were affected on a turkey farm in Ottawa County, the state's third detection in commercial turkeys in less than a week.
Even without a booster, the vaccine triggered mucosal and systemic immunity, which other intranasal recombinant H5 flu vaccines have not achieved in clinical trials.
Elsewhere, 2 large poultry outbreaks were reported in Lagrange County, Indiana.
Grant County, Washington, recently had 7 avian flu detections in wild birds.
The findings highlight a critical gap in many national and global H5N1 surveillance systems.
In September cholera cases were down 27% from August.
Senegal's Rift Valley fever outbreak now has 302 confirmed cases.
Chicken farms in Georgia and Pennsylvania were also hit with high-path avian flu.
Six Canada geese in Campaign County, Illinois, died from H5N1, as did 6 geese found in Kent County, Michigan.
Avian flu activity is increasing across the county after relatively few detections this summer.
