Biosecurity Issues

Recent News

Oct 01, 2013

News Scan for Oct 01, 2013

More Saudi MERS cases
Boston BSL-4 lab clears hurdle
Colorado TB investigation
Hepatitis C screening
Polio in South Sudan
Sep 06, 2013

Think tank sees big risks in flu gain-of-function research

A new assessment says that avian flu "gain of function" research poses a serious outbreak risk.

Aug 14, 2013

Study: Technique adds 'kill switch' to modified flu viruses

A new molecular strategy could diffuse some of the controversy over lab-modified flu viruses.

Jun 18, 2013

Doubts about BioWatch program aired in Congress again

Doubts about BioWatch were aired in Congress today, with a House committee chair criticizing plans and a top federal disease expert expressing concerns.

May 02, 2013

Study: Lab-made H5N1-H1N1 viruses spread in guinea pigs

(CIDRAP News) – Chinese scientists report that lab-generated hybrid viruses combining genes from avian H5N1 and pandemic 2009 H1N1 (pH1N1) influenza viruses can achieve airborne spread between guinea pigs, a finding that seems likely to renew the debate about the risks of creating novel viruses that might be able to spark a human pandemic.

Apr 25, 2013

Study: Lab-derived H5N1 virus component binds to human receptors

(CIDRAP News) – A new study suggests that a lab-derived hybrid H5N1 influenza virus that is capable of airborne transmission among ferrets may well be capable of doing the same thing in humans.

Apr 05, 2013

China confirms H7N9 in poultry, more human cases

(CIDRAP News) – Chinese agriculture officials today confirmed the H7N9 virus in chickens and pigeons from Shanghai markets, providing new clues about how humans may have been exposed to the virus, which has since yesterday been detected in two more people.

Resources & Literature

Recent Literature

Blaine JW. Establishing a national biological laboratory safety and security monitoring program. Biosecur Bioterror 2012 Dec 17;10(4):396-400

Fouchier RAM, Garcia-Sastre A, Kawaoka Y, et al. H5N1 virus: transmission studies resume for avian flu. (Letter) Nature 2013 Jan 31;493:609 

Gangadharan D, Smith J, Weyant R. Biosafety recommendations for work with influenza viruses containing a hemagglutinin from the A/goose/Guangdong/1/96 lineage. MMWR 2013 Jun 28;62(rr06):1-7

GAO (US Government Accountability Office). High-containment laboratories: assessment of the nation's need is missing. GAO-13-466R. Posted Mar 25, 2013 (but dated Feb 25) 

Higgins JJ, Weaver P, Fitch P, et al. Implementation of a personnel reliability program as a facilitator of biosafety and biosecurity culture in BSL-3 and BSL-4 laboratories. Biosec Bioterror 2013 Jun 18;11(2):130-7

IOM (Institute of Medicine). Perspectives on research with H5N1 avian influenza: scientific inquiry, communication, controversy: summary of a workshop. Apr 8, 2013 

Lipkin WI. Biocontainment in gain-of-function infectious disease research. (Commentary) mBio 2012 Oct 9;3(5):e00290-12 

Merens A, Cavallo JD, Thibault F, et al. Assessment of the bio-preparedness and of the training of the French hospital laboratories in the event of biological threat. Euro Surveill 2012 Nov 8;17(45):pii=20312

Nature editors. Vigilance needed. (Editorial) Nature 2013 Jan 23;493(7433):451-2

Patterson AP, Tabak LA, Fauci AS, et al. A framework for decisions about research with HPAI H5N1 viruses. Science 2013 Mar 1;339(6123):1036-7

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