Clostridium difficile

Recent News

Nov 09, 2018

Stewardship / Resistance Scan for Nov 09, 2018

Antibiotics in long-term care facilities
C diff and adverse outcomes
Stewardship in India
Oct 26, 2018

Stewardship / Resistance Scan for Oct 26, 2018

Stewardship to reduce C diff
Declining ear infections, antibiotics
Oct 16, 2018

Stewardship / Resistance Scan for Oct 16, 2018

C difficile on hospital bed sheets
Colistin resistance diagnostics
Dearth of point-of-care tests
New-antibiotic distribution
Oct 12, 2018

Stewardship / Resistance Scan for Oct 12, 2018

Antibiotic duration for group B strep
C diff risk and antibiotics
Veterinary pharma controversy
Sep 11, 2018

Stewardship / Resistance Scan for Sep 11, 2018

Antibiotics and cough
Piperacillin-tazobactam trial results
Double antibiotic for pneumonia
C diff in food animals
Aug 31, 2018

Stewardship / Resistance Scan for Aug 31, 2018

C diff testing in the NICU
Resistant gonorrhea in Europe
ESBL bacteria in sprouts
Aug 29, 2018

Stewardship / Resistance Scan for Aug 29, 2018

UK FMT C diff guidelines
Pharmacist-led stewardship
Typhoid vaccine as stewardship tool
Jul 31, 2018

Stewardship / Resistance Scan for Jul 31, 2018

MDR infection and mortality risk
CARB-X funds C diff drug
Jul 17, 2018

Stewardship / Resistance Scan for Jul 17, 2018

C diff treatment comparison
Antifungal stewardship
Funds for resistant UTI
Jun 28, 2018
antibiotic packets

Penicillin-allergic patients may run bigger risk of MRSA, C diff

Patients incorrectly labeled as allergic to penicillin are more likely to receive broad-spectrum antibiotics, a practice that promotes resistance.

Resources & Literature

Recent Literature

Albert K, Ross B, Calfee DP, et al. Overreporting healthcare-associated C. difficile: a comparison of NHSN LabID with clinical surveillance definitions in the era of molecular testing. Am J Infect Control 2018 (published online Apr 11)

Beinortas T, Burr NE, Wilcox MH, et al. Comparative efficacy of treatments for Clostridium difficile infection: a systematic review and network meta-analysis. Lancet Infect Dis 2018 (published online Jul 16)

Birch T, Golan Y, Rizzardini G, et al. Efficacy of bezlotoxumab based on timing of administration relative to start of antibacterial therapy for Clostridium difficile infection. J Antimicrob Chemother 2018 (published online May 16)

Brite J, McMillen T, Robilotti E, et al. Effectiveness of ultraviolet disinfection in reducing hospital-acquired Clostridium difficile and vancomycin-resistant Enterococcus on a bone marrow transplant unit. Infect Control Hosp Epidemiol 2018 (published online Sep 18)

Bruno-Murtha LA, Osgood RA, Alexandre CE. A successful strategy to decrease hospital-onset Clostridium difficile. Infect Control Hosp Epidemiol 2018 (published online Jan 5)

Casari E, De Luca C, Calabro M, et al. Reducing rates of Clostridium difficile infection by switching to a stand-alone NAAT with clear sampling criteria. Antimicrob Resis Infect Control 2018 Mar 12;7:40

Chaisson LH, Duong D, Cattamanchi A, et al. Association of rapid molecular testing with duration of respiratory isolation for patients with possible tuberculosis in a US hospital. JAMA Intern Med 2018 (published online Aug 27)

Kong LY, Eyre DW, Corbeil J, et al. Clostridium difficile: investigating transmission patterns between infected and colonized patients using whole genome sequencing. Clin Infect Dis 2018 (published online May 28)

Dong D, Ni Q, Wang C, et al. Effects of intestinal colonization by Clostridium difficile and Staphylococcus aureus on microbiota diversity in healthy individuals in China. BMC Infect Dis 2018 May 3;18:207

Dotson KM, Aitken SL, Sofjan AK, et al. Outcomes associated with Clostridium difficile infection in patients with chronic liver disease. Epidemiol Infect 2018 (published online May 9)

Dubberke ER, Lee CH, Orenstein R, et al. Results from a randomized placebo-controlled clinical trial of a RBX2660 — a microbiota-based drug for the prevention of recurrent Clostridium difficile infection. Clin Infect Dis 2018 (published online Mar 29)

Dubberke ER, Reske KA, Hink T, et al. Clostridium difficile colonization among patients with clinically significant diarrhea and no identifiable cause of diarrhea. Infect Control Hosp Epidemiol 2018 (published online Sep 18)

Endres BT, Dotson KM, Poblete K, et al. Environmental transmission of Clostridioides difficile ribotype 027 at a long-term care facility; an outbreak investigation guided by whole genome sequencing. Infect Control Hosp Epidemiol 2018 (published online Sep 2018)

Eyre DW, Davies KA, Davis G, et al. Two distinct patterns of Clostridium difficile diversity across Europe indicates contrasting routes of spread. Clin Infect Dis 2018 (published online Apr 6)

Fabre V, Markou T, Sick-Samuels A, et al. Impact of case-specific education and face-to-face feedback to prescribers and nurses in the management of hospitalized patients with a positive Clostridium difficile test. Open Forum Infect Dis 2018 (published online Sep 10)

Ganetsky A, Han JH, Hughes ME, et al. Oral vancomycin prophylaxis is highly effective in preventing Clostridium difficile infection in allogeneic hematopoietic cell transplant recipients. Clin Infect Dis 2018 (published online Sep 26)

Gerding DN, Kelly CP, Rahav G, et al. Bezlotoxumab for prevention of recurrent C. difficile infection in patients at increased risk for recurrence. Clin Infect Dis 2018 (published online Mar 10)

Grimmond T, Neelakanta A, Miller B, et al. A microbiological study to investigate the carriage and transmission-potential of Clostridium difficile spores on single-use and reusable sharps containers. Am J Infect Control 2018 (published online May 22)

Guery B, Menichetti F, Anttila VJ, et al. Extended-pulsed fidaxomicin versus vancomycin for Clostridium difficile infection in patients 60 years and older (EXTEND): a randomised, controlled, open-label, phase 3b/4 trial. Lancet Infect Dis 2017 (published online Dec 19)

Guh AY, Mu Y, Baggs J, et al. Trends in incidence of long-term-care facility onset Clostridium difficile infections in 10 US geographic locations during 2011-2015. Am J Infect Control 2018 (published online Jan 9)

Gupta A, Cifu AS, Khanna S. Diagnosis and treatment of Clostridium difficile infection. JAMA 2018 (published online Aug 27)

Jamot S, Raghunathan V, Patel K, et al. Factors associated with the use of fecal microbiota transplant in patients with recurrent Clostridium difficile infections. Infect Control Hosp Epidemiol 2018 (published online Jan 24)

Jin SJ, Seo KH, Wi YM. The effect of concomitant use of systemic antibiotics in patients with Clostridium difficile infection receiving metronidazole therapy. Epidemiol Infect 2018 (published online Mar 1)

Johnston BC, Lytvyn L, Lo CKF, et al. Microbial preparations (probiotics) for the prevention of Clostridium difficile infection in adults and children: an individual patient data meta-analysis of 6,851 participants. Infect Control Hosp Epidemiol 2018 (published online Apr 26)

Juul FE, Bretthauer M, Skudal H, et al. Fecal microbiota transplantation for primary Clostridium difficile infection. (Letter) N Engl J Med 2018 (published online Jun 2)

Newsletter Sign-up

Get CIDRAP news and other free newsletters.

Sign up now»


Unrestricted financial support provided by

Bentson Foundation 3MAccelerate DiagnosticsGilead Become an underwriter»