Clostridium difficile

Recent News

Apr 12, 2018

Stewardship / Resistance Scan for Apr 12, 2018

Overreporting C difficile
MCR-1 in travelers
Drivers of irrational antibiotic use
Apr 04, 2018

Stewardship / Resistance Scan for Apr 04, 2018

Defensive prescribing
C diff drop with diagnostic stewardship
AMR levels in Cambodian kids
Mar 29, 2018

Stewardship / Resistance Scan for Mar 29, 2018

Candida auris in Europe
Experimental C diff drug
Mar 26, 2018

Stewardship / Resistance Scan for Mar 26, 2018

Cornerstones of stewardship
Resistant Acinetobacter in kids
C diff prediction tool
Perceived AMR risk in Germany
Mar 20, 2018

Stewardship / Resistance Scan for Mar 20, 2018

Resistant TB in Europe
Appropriate C diff testing
Fast sepsis detection
Mar 07, 2018

Stewardship / Resistance Scan for Mar 07, 2018

MDR bacteria in Italy
Guidance on C diff prevention
Mar 02, 2018

Stewardship / Resistance Scan for Mar 02, 2018

Resident prescribing savvy
Monitoring animal antibiotics
C diff treatment failure predictors
Feb 22, 2018

Stewardship / Resistance Scan for Feb 22, 2018

Cost-effective C diff treatment
Latent TB guidelines
Feb 16, 2018
Clostridium difficile

New C diff guidelines incorporate fecal transplant

IDSA/SHEA guidelines recommend fecal microbiota transplantation for patients with multiple recurrences.

Jan 29, 2018

Stewardship / Resistance Scan for Jan 29, 2018

Oral C diff drug approved
Tailored UTI prescribing
Zinc in pig feed and MDR E coli

Resources & Literature

Recent Literature

AHRQ. Diagnosis, prevention, and treatment of C. difficile: current state of the evidence. May 30, 2017

Albert K, Ross B, Calfee DP, et al. Overreporting healthcare-associated C. difficile: a comparison of NHSN LabID with clinical surveillance definitions in the era of molecular testing. Am J Infect Control 2018 (published online Apr 11)

Bernatz JT, Safdar N, Hetzel S, et al.  Antibiotic overuse is a major risk factor for Clostridium difficile infection in surgical patients. Infect Control Hosp Epidemiol 2017 (published online Jul 31)

Borren NZ, Ghadermarzi S, Hutfless S, et al. The emergence of Clostridium difficile infection in Asia: a systematic review and meta-analysis of incidence and impact. PLoS One 2017 May 2;12(5):e0176797

Brown KA, Daneman N, Jones M, et al. The drivers of acute and long-term care C. difficile infection rates: a retrospective multilevel cohort study of 251 facilities. Clin Infect Dis 2017 (published online Jun 8)

Bruno-Murtha LA, Osgood RA, Alexandre CE. A successful strategy to decrease hospital-onset Clostridium difficile. Infect Control Hosp Epidemiol 2018 (published online Jan 5)

Casari E, De Luca C, Calabro M, et al. Reducing rates of Clostridium difficile infection by switching to a stand-alone NAAT with clear sampling criteria. Antimicrob Resis Infect Control 2018 Mar 12;7:40

Cheong E, Roberts T, Rattanavong S, et al. Clostridium difficile infection  in the Lao People’s Democratic Republic: first isolation and review of the literature. BMC Infect Dis 2017 Sep 21;17:635

Delgado A, Reveles IA, Cabello FT, et al. Poorer outcomes among cancer patients diagnosed with Clostridium difficile infections in United States community hospitals. BMC Infect Dis 2017 Jun 23;17:448

Deschenes P, Chano F, Dionne LL, et al. Efficacy of the World Health Organization-recommended handwashing technique and a modified washing technique to remove Clostridium difficile from hands. Am J Infect Control 2017 (published online May 16)

Dubberke ER, Lee CH, Orenstein R, et al. Results from a randomized placebo-controlled clinical trial of a RBX2660 — a microbiota-based drug for the prevention of recurrent Clostridium difficile infection. Clin Infect Dis 2018 (published online Mar 29)

Eyre DW, Davies KA, Davis G, et al. Two distinct patterns of Clostridium difficile diversity across Europe indicates contrasting routes of spread. Clin Infect Dis 2018 (published online Apr 6)

Gerding DN, Kelly CP, Rahav G, et al. Bezlotoxumab for prevention of recurrent C. difficile infection in patients at increased risk for recurrence. Clin Infect Dis 2018 (published online Mar 10)

Goda H, Yamaoka H, Nakayama-Imaohji H, et al. Microbicidal effects of weakly acidified chlorous acid water against feline calcivirus and Clostridium difficile spores under protein-rich conditions. PLoS One 2017 May 4;12(5):e0176718

Gross AE, Johannes RS, Gupta V, et al. The effect of a piperacillin/tazobactam shortage on antimicrobial prescribing and Clostridium difficile risk in 88 U.S. medical centers. Clin Infect Dis 2017 (published online Apr 24)

Grzeskowiak L, Martinez-Vallespin B, Dadi TH, et al. Formula-feeding predisposes neonatal piglets to Clostridium difficile gut infection. J Infect Dis 2017 (published online Nov 1)

Guery B, Menichetti F, Anttila VJ, et al. Extended-pulsed fidaxomicin versus vancomycin for Clostridium difficile infection in patients 60 years and older (EXTEND): a randomised, controlled, open-label, phase 3b/4 trial. Lancet Infect Dis 2017 (published online Dec 19)

Guh AY, Mu Y, Baggs J, et al. Trends in incidence of long-term-care facility onset Clostridium difficile infections in 10 US geographic locations during 2011-2015. Am J Infect Control 2018 (published online Jan 9)

Hiensch R, Poeran J, Saunders-Hao P, et al. Impact of an electronic sepsis initiative on antibiotic use and health care facility-onset Clostridium difficile infection rates. Am J Infect Control 2017 (published online Jun 8)

Hocquart M, Lagier JC, Cassir N, et al. Early faecal microbiota transplantation improves survival in severe Clostridium difficile infections. Clin Infect Dis 2017 (published online Aug 24)

Jamot S, Raghunathan V, Patel K, et al. Factors associated with the use of fecal microbiota transplant in patients with recurrent Clostridium difficile infections. Infect Control Hosp Epidemiol 2018 (published online Jan 24)

Jin SJ, Seo KH, Wi YM. The effect of concomitant use of systemic antibiotics in patients with Clostridium difficile infection receiving metronidazole therapy. Epidemiol Infect 2018 (published online Mar 1)

Kamboj M, Brite J, Aslam A, et al. Artificial differences in Clostridium difficile infection rates associated with disparity in testing. Emerg Infect Dis 2018 (published online Jan 30)

Kenters N, Huijskens EGW, de Wit SCJ, et al. Effectiveness of various cleaning and disinfectant products on Clostridium difficile spores of PCR ribotypes 010, 014 and 027. Antimicrob Resist Infect Control 2017 June 2;6:54

Kociolek LK, Gerding DN, Espinosa RO, et al. Clostridium difficile whole genome sequencing reveals limited transmission among symptomatic children: a single-center analysis. Clin Infect Dis 2018 (published online Jan 23)

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