Clostridium difficile

Recent News

Jun 28, 2018
antibiotic packets

Penicillin-allergic patients may run bigger risk of MRSA, C diff

Patients incorrectly labeled as allergic to penicillin are more likely to receive broad-spectrum antibiotics, a practice that promotes resistance.

Jun 25, 2018
Clostridium difficile bacteria

Significant C diff reduction noted in Canadian hospitals

Healthcare-related CDI fell from 5.9 to 4.3 per 10,000 patient-days, a 27% reduction.

Jun 25, 2018

Stewardship / Resistance Scan for Jun 25, 2018

Letter-based antibiotic prescribing intervention
CMS proposes less hospital infection reporting
Jun 05, 2018
Empty hospital room

UV-light cleaning shown to cut superbugs hospital-wide

Adding ultraviolet light to standard room cleaning modestly decreases hospital-wide superbugs.

Jun 04, 2018

Stewardship / Resistance Scan for Jun 04, 2018

Antibiotic alternative for acne
Fecal transplant for primary C diff
May 23, 2018

Stewardship / Resistance Scan for May 23, 2018

NDM plus MCR-1 in E coli
C diff and sharps containers
Apr 26, 2018

Stewardship / Resistance Scan for Apr 26, 2018

Mass distribution of azithromycin
Probiotics and CDI
New CARB-X funding
Apr 12, 2018

Stewardship / Resistance Scan for Apr 12, 2018

Overreporting C difficile
MCR-1 in travelers
Drivers of irrational antibiotic use
Apr 04, 2018

Stewardship / Resistance Scan for Apr 04, 2018

Defensive prescribing
C diff drop with diagnostic stewardship
AMR levels in Cambodian kids
Mar 29, 2018

Stewardship / Resistance Scan for Mar 29, 2018

Candida auris in Europe
Experimental C diff drug

Resources & Literature

Recent Literature

Albert K, Ross B, Calfee DP, et al. Overreporting healthcare-associated C. difficile: a comparison of NHSN LabID with clinical surveillance definitions in the era of molecular testing. Am J Infect Control 2018 (published online Apr 11)

Bernatz JT, Safdar N, Hetzel S, et al.  Antibiotic overuse is a major risk factor for Clostridium difficile infection in surgical patients. Infect Control Hosp Epidemiol 2017 (published online Jul 31)

Birch T, Golan Y, Rizzardini G, et al. Efficacy of bezlotoxumab based on timing of administration relative to start of antibacterial therapy for Clostridium difficile infection. J Antimicrob Chemother 2018 (published online May 16)

Bruno-Murtha LA, Osgood RA, Alexandre CE. A successful strategy to decrease hospital-onset Clostridium difficile. Infect Control Hosp Epidemiol 2018 (published online Jan 5)

Casari E, De Luca C, Calabro M, et al. Reducing rates of Clostridium difficile infection by switching to a stand-alone NAAT with clear sampling criteria. Antimicrob Resis Infect Control 2018 Mar 12;7:40

Cheong E, Roberts T, Rattanavong S, et al. Clostridium difficile infection  in the Lao People’s Democratic Republic: first isolation and review of the literature. BMC Infect Dis 2017 Sep 21;17:635

Kong LY, Eyre DW, Corbeil J, et al. Clostridium difficile: investigating transmission patterns between infected and colonized patients using whole genome sequencing. Clin Infect Dis 2018 (published online May 28)

Dong D, Ni Q, Wang C, et al. Effects of intestinal colonization by Clostridium difficile and Staphylococcus aureus on microbiota diversity in healthy individuals in China. BMC Infect Dis 2018 May 3;18:207

Dotson KM, Aitken SL, Sofjan AK, et al. Outcomes associated with Clostridium difficile infection in patients with chronic liver disease. Epidemiol Infect 2018 (published online May 9)

Dubberke ER, Lee CH, Orenstein R, et al. Results from a randomized placebo-controlled clinical trial of a RBX2660 — a microbiota-based drug for the prevention of recurrent Clostridium difficile infection. Clin Infect Dis 2018 (published online Mar 29)

Eyre DW, Davies KA, Davis G, et al. Two distinct patterns of Clostridium difficile diversity across Europe indicates contrasting routes of spread. Clin Infect Dis 2018 (published online Apr 6)

Gerding DN, Kelly CP, Rahav G, et al. Bezlotoxumab for prevention of recurrent C. difficile infection in patients at increased risk for recurrence. Clin Infect Dis 2018 (published online Mar 10)

Grimmond T, Neelakanta A, Miller B, et al. A microbiological study to investigate the carriage and transmission-potential of Clostridium difficile spores on single-use and reusable sharps containers. Am J Infect Control 2018 (published online May 22)

Grzeskowiak L, Martinez-Vallespin B, Dadi TH, et al. Formula-feeding predisposes neonatal piglets to Clostridium difficile gut infection. J Infect Dis 2017 (published online Nov 1)

Guery B, Menichetti F, Anttila VJ, et al. Extended-pulsed fidaxomicin versus vancomycin for Clostridium difficile infection in patients 60 years and older (EXTEND): a randomised, controlled, open-label, phase 3b/4 trial. Lancet Infect Dis 2017 (published online Dec 19)

Guh AY, Mu Y, Baggs J, et al. Trends in incidence of long-term-care facility onset Clostridium difficile infections in 10 US geographic locations during 2011-2015. Am J Infect Control 2018 (published online Jan 9)

Hocquart M, Lagier JC, Cassir N, et al. Early faecal microbiota transplantation improves survival in severe Clostridium difficile infections. Clin Infect Dis 2017 (published online Aug 24)

Jamot S, Raghunathan V, Patel K, et al. Factors associated with the use of fecal microbiota transplant in patients with recurrent Clostridium difficile infections. Infect Control Hosp Epidemiol 2018 (published online Jan 24)

Jin SJ, Seo KH, Wi YM. The effect of concomitant use of systemic antibiotics in patients with Clostridium difficile infection receiving metronidazole therapy. Epidemiol Infect 2018 (published online Mar 1)

Johnston BC, Lytvyn L, Lo CKF, et al. Microbial preparations (probiotics) for the prevention of Clostridium difficile infection in adults and children: an individual patient data meta-analysis of 6,851 participants. Infect Control Hosp Epidemiol 2018 (published online Apr 26)

Juul FE, Bretthauer M, Skudal H, et al. Fecal microbiota transplantation for primary Clostridium difficile infection. (Letter) N Engl J Med 2018 (published online Jun 2)

Kamboj M, Brite J, Aslam A, et al. Artificial differences in Clostridium difficile infection rates associated with disparity in testing. Emerg Infect Dis 2018 (published online Jan 30)

Katz KC, Golding GR, Choi KB, et al. The evolving epidemiology of Clostridium difficile infection in Canadian hospitals during a postepidemic period (2009-2015). CMAJ 2018 Jun 25;190(25):E758-65

Kociolek LK, Gerding DN, Espinosa RO, et al. Clostridium difficile whole genome sequencing reveals limited transmission among symptomatic children: a single-center analysis. Clin Infect Dis 2018 (published online Jan 23)

Kumar S, Ster IC, Pollok R, et al. The epidemiology of community Clostridium difficile infection: a five-year population-based study on the Bailiwick of Jersey, Channel Islands. Infect Control Hosp Epidmiol 2018 (published online Feb 27)

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