Clostridium difficile

Recent News

Mar 18, 2019
C difficile

Phase 2 data boost new drug for preventing C diff infections

The drug cut the incidence of C difficile by 2.4 percentage points—a 71% relative risk reduction.

Mar 01, 2019

Stewardship / Resistance Scan for Mar 01, 2019

Antibiotic stewardship and C diff
CPE activity increase in Europe
Feb 18, 2019

Stewardship / Resistance Scan for Feb 18, 2019

Resistant bacteria in farm soil
Geographic MRSA risks
Readmission after C diff
Feb 15, 2019

Stewardship / Resistance Scan for Feb 15, 2019

Electronic stewardship intervention
Antibiotic resistance and UTI risk
C diff testing in children
Jan 30, 2019

Stewardship / Resistance Scan for Jan 30, 2019

Proposed UN AMR guidance
European antibiotic use survey
Antibiotic use in nursing homes
Novel antibiotic vs C diff
Jan 23, 2019

Stewardship / Resistance Scan for Jan 23, 2019

Benefit of C diff prevention
Prescribing drop in England
Candida auris increase
Jan 22, 2019

Stewardship / Resistance Scan for Jan 22, 2019

Antibiotics for respiratory infections
UTI treatment in older adults
Super donors for fecal transplant
Resistant cholera in Ghana
Jan 17, 2019

Stewardship / Resistance Scan for Jan 17, 2019

Antibiotic overprescribing in tots
Fast track for new C diff drug
Jan 14, 2019

Stewardship / Resistance Scan for Jan 14, 2019

Stewardship in English hospitals
Whiff of C diff in pets
Fecal microbiota transplant trial
Dec 19, 2018

Stewardship / Resistance Scan for Dec 19, 2018

Sparse antibiotic use and resistance
Metronidazole for mild C diff

Resources & Literature

Recent Literature

Ahmed J, Kumar A, Jafri F, et al. Low incidence of hospital-onset Clostridium difficile infection in sickle cell disease. (Letter) N Engl J Med 2019 Feb 28;380(9):887-8

Aithinne KA, Cooper CW, Lynch RA, et al. Toilet plume aerosol generation rate and environmental contamination following bowl water inoculation with Clostridium difficile spores. Am J Infect Control 2018 (published online Dec 14)

Albert K, Ross B, Calfee DP, et al. Overreporting healthcare-associated C. difficile: a comparison of NHSN LabID with clinical surveillance definitions in the era of molecular testing. Am J Infect Control 2018 (published online Apr 11)

Aldrich AM, Argo T, Koehler TJ, et al. Analysis of treatment outcomes for recurrent Clostridium difficile infections and feca microbiota transplantation in a pediatric hospital. Pediatr Infect Dis J 2019 Jan;38(1):32-6

Anjewierden S, Han Z, Foster CB, et al. Risk factors for Clostridium difficle infection in pediatric inpatients: a meta-analysis and systematic review. Infect Control Hosp Epidemiol 2019 (published online Mar 7)

Appaneal HJ, Caffrey AR, LaPlante KL. What is the role for metronidazole in the treatment of Clostridium difficile infection? Results from a national cohort study of veterans with initial mild disease. Clin Infect Dis 2018 (published online Dec 18)

Barbut F, Day N, Bouee S, et al. Toxigenic Clostridium difficile carriage in general practice: results of a laboratory-based cohort study. Clin Microbiol Infect 2019 (published online Jan 4)

Beinortas T, Burr NE, Wilcox MH, et al. Comparative efficacy of treatments for Clostridium difficile infection: a systematic review and network meta-analysis. Lancet Infect Dis 2018 (published online Jul 16)

Birch T, Golan Y, Rizzardini G, et al. Efficacy of bezlotoxumab based on timing of administration relative to start of antibacterial therapy for Clostridium difficile infection. J Antimicrob Chemother 2018 (published online May 16)

Brite J, McMillen T, Robilotti E, et al. Effectiveness of ultraviolet disinfection in reducing hospital-acquired Clostridium difficile and vancomycin-resistant Enterococcus on a bone marrow transplant unit. Infect Control Hosp Epidemiol 2018 (published online Sep 18)

Casari E, De Luca C, Calabro M, et al. Reducing rates of Clostridium difficile infection by switching to a stand-alone NAAT with clear sampling criteria. Antimicrob Resis Infect Control 2018 Mar 12;7:40

Chaisson LH, Duong D, Cattamanchi A, et al. Association of rapid molecular testing with duration of respiratory isolation for patients with possible tuberculosis in a US hospital. JAMA Intern Med 2018 (published online Aug 27)

Kong LY, Eyre DW, Corbeil J, et al. Clostridium difficile: investigating transmission patterns between infected and colonized patients using whole genome sequencing. Clin Infect Dis 2018 (published online May 28)

Dong D, Ni Q, Wang C, et al. Effects of intestinal colonization by Clostridium difficile and Staphylococcus aureus on microbiota diversity in healthy individuals in China. BMC Infect Dis 2018 May 3;18:207

Dotson KM, Aitken SL, Sofjan AK, et al. Outcomes associated with Clostridium difficile infection in patients with chronic liver disease. Epidemiol Infect 2018 (published online May 9)

Dubberke ER, Lee CH, Orenstein R, et al. Results from a randomized placebo-controlled clinical trial of a RBX2660 — a microbiota-based drug for the prevention of recurrent Clostridium difficile infection. Clin Infect Dis 2018 (published online Mar 29)

Dubberke ER, Reske KA, Hink T, et al. Clostridium difficile colonization among patients with clinically significant diarrhea and no identifiable cause of diarrhea. Infect Control Hosp Epidemiol 2018 (published online Sep 18)

Endres BT, Dotson KM, Poblete K, et al. Environmental transmission of Clostridioides difficile ribotype 027 at a long-term care facility; an outbreak investigation guided by whole genome sequencing. Infect Control Hosp Epidemiol 2018 (published online Sep 2018)

Eyre DW, Davies KA, Davis G, et al. Two distinct patterns of Clostridium difficile diversity across Europe indicates contrasting routes of spread. Clin Infect Dis 2018 (published online Apr 6)

Fabre V, Markou T, Sick-Samuels A, et al. Impact of case-specific education and face-to-face feedback to prescribers and nurses in the management of hospitalized patients with a positive Clostridium difficile test. Open Forum Infect Dis 2018 (published online Sep 10)

Ford CD, Lopansri BK, Webb BJ, et al. Clostridioides difficile colonization and infection in patients with newly diagnosed acute leukemia: incidence, risk factors, and patient outcomes. Am J Infect Control 2018 (published online Nov 22)

Ganetsky A, Han JH, Hughes ME, et al. Oral vancomycin prophylaxis is highly effective in preventing Clostridium difficile infection in allogeneic hematopoietic cell transplant recipients. Clin Infect Dis 2018 (published online Sep 26)

Gerding DN, Cornely OA, Grill S, et al. Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials. Lancet Infect Dis 2019 (published online Jan 29)

Gerding DN, Kelly CP, Rahav G, et al. Bezlotoxumab for prevention of recurrent C. difficile infection in patients at increased risk for recurrence. Clin Infect Dis 2018 (published online Mar 10)

Gonzalez-Orta, M, Saldana C, Ng-Wong Y, et al. Are many patients diagnosed with healthcare-associated Clostriodioides difficile infection colonized with the infecting strain on admission? Clin Infect Dis 2019 (published online Mar 11)

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