Fungal Infection

Recent News

Sep 21, 2017

Stewardship / Resistance Scan for Sep 21, 2017

MDR malaria spread
Pediatric antimicrobial stewardship
New US Candida auris cases
Aug 22, 2017

News Scan for Aug 22, 2017

Saudi MERS case
Candida auris uptick
Tainted sprouts
Aug 18, 2017

Stewardship / Resistance Scan for Aug 18, 2017

Antifungal susceptibility testing
Bacteriophage therapy
Expanded AMR monitoring
Aug 17, 2017

Antifungal development gets new attention

With resistance emerging to a limited set of treatment options, new drugs for invasive fungal infections are desperately needed.

Aug 15, 2017

Candida auris spreading in UK hospitals

About a quarter of the 200 colonized patients had clinical illness, including 27 with bloodstream infections.

Jul 20, 2017
Scientist at microscope

CDC keeping a watchful eye on Candida auris

If illness from the fungus becomes more common, "We are dealing with the potential for a highly resistant bug to really take off."

Jul 17, 2017
Candida auris

CDC reports uptick in Candida auris cases

Also, the CDC said C auris has been isolated from 110 more patients hospitalized in three affected states.

Jul 11, 2017

Stewardship / Resistance Scan for Jul 11, 2017

Candida auris in Canada
MCR-1 in Vietnamese hospital
Jun 27, 2017
Spinal nerve block

Head of fungal meningitis outbreak pharmacy sentenced to 9 years in prison

In the wake of new laws and tighter federal oversight, the FDA has done more than 400 inspections, sent 150 warning letters, and overseen 125 recalls.

Jun 20, 2017

Stewardship / Resistance Scan for Jun 20, 2017

New antibiotic OK'd
MDR-TB in US kids
Virus tests and stewardship
Penalties for poor Rx
US Candida auris
Resistance testing

Resources & Literature

Recent Literature

Baldesi O, Bailly S, Ruckly S, et al. ICU-acquired candidaemia in France: epidemiology and temporal trends, 2004-2013 — a study from the REA-RAISIN network. J Infect 2017 (published online Mar 30)

Barberan J, Garcia-Perez FJ, Villena V, et al. Development of aspergillosis in a cohort of non-neutropenic, non-transplant patients colonised by Aspergillus spp. BMC Infect Dis 2017 Jan 6;17:34

Barchiesi F, Orsetti E, Mazzanti S, et al. Candidemia in the elderly: what does it change? PLoS One 2017 May 11;12(5):e0176576

Barton M, Shen A, O'Brien K, et al. Early onset invasive candidiasis in extremely low birth weight infants: perinatal acquisition predicts poor outcome. Clin Infect Dis 2017 (published online Jan 11)

Ben-Ami R, Berman J, Novikov A, et al. Multidrug-resistant Candida haemulonii and C. auris, Tel Aviv, Israel. Emerg Infect Dis 2017 (published online Jan 12)

Benedict K, Richardson M, Vallabhaneni S, et al. Emerging issues, challenges, and changing epidemiology of fungal disease outbreaks. Lancet Infect Dis 2017 (published online Jul 31)

Chen K, Wang Q, Pleasants RA, et al. Empiric treatment against invasive fungal diseases in febrile neutropenic patients: a systematic review and network meta-analysis. BMC Infect Dis 2017 Feb 20;17:159

Chowdhary A, Sharma C, Meis JF. Candida auris: a rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally. PLoS Pathog 2017 May 18;13(45):e1006290

Cole DC, Govender NP, Chakrabarti A, et al. Improvement of fungal disease identification and management: combined health systems and public health approaches. Lancet Infect Dis 2017 (published online Jul 31)

Gomez CA, Budvytiene I, Zemek AJ, et al. Performance of targeted fungal sequencing for culture-independent diagnosis of invasive fungal disease. Clin Infect Dis 2017 (published online Aug 17)

Kang SJ, Kim SE, Kim UJ, et al. Clinical characteristics and risk factors for mortality in adult patients with persistent candidemia. J Infection 2017 (published online Jun 3)

Kaufman DA, Coggins SA, Zanelli SA, et al. Congenital cutaneous candidiasis: prompt systemic treatment is associated with improved outcomes in neonates. Clin Infect Dis 2017 (published online Feb 4)

Larkin E, Hager C, Chandra J, et al. The emerging Candida auris: characterization of growth phenotype, virulence factors, antifungal activity, and effect of SCY-08, a novel glucan synthesis inhibitor, on growth morphology and biofilm formation. Antimicrob Agents Chemother 2017 (published online Feb 21)

Martin JM, Macias-Parra M, Mudry P, et al. Safety, efficacy, and exposure-response of voriconazole in pediatric patients with invasive aspergillosis, invasive candidiasis or esophageal candidiasis. Pediatr Infect Dis J 2017 Jan;36(1):e1-13

Morales-Lopez SE, Parra-Giraldo CM, Ceballos-Garzon A, et al. Invasive infections with multidrug-resistant yeast Candida auris, Colombia. Emerg Infect Dis 2016 (published online Dec 5)

Negri CE, Johnson A, McEntee L, et al. Pharmacodynamics of the novel antifungal agent F901318 for acute sinopulmonary aspergillosis caused by Aspergillus flavus. J Infect Dis 2017 (published online Sep 12)

Pegorie M, Denning DW, Welfare W. Estimating the burden of invasive and serious fungal disease in the United Kingdom. J Infect 2016 (published online Oct 24)

Perlin DS, Rautemaa-Richardson R, Alastruey-Izquierdo A. The global problem of antifungal resistance: prevalence, mechanisms, and management. Lancet Infect Dis 2017 (published online Jul 31)

Renfrow JJ, Frenkel MB, Hsu W. Fungal contamination of methylprednisolone causing recurrent lumbosacral intradural abscess. Emerg Infect Dis 2017 (published online Jan 31)

Sherry L, Ramage G, Kean R, et al. Biofilm-forming capability of highly virulent, multidrug-resistant Candida auris. Emerg Infect Dis 2017 (published online Jan 11)

Strollo S, Lionakis MS, Adjemian J, et al. Epidemiology of hospitalizations associated with invasive candidiasis, United States, 2002-2012. Emerg Infect Dis 2016 (published online Dec 14)

Timsit JF, Azoulay E, Schwebel C, et al. Empirical micafungin treatment and survival without invasive fungal infection in adults with ICU-acquired sepsis, Candida colonization, and multiple organ failure: the EMPERICUS randomized clinical trial. JAMA 2016 (published online Oct 5)

Tsay S, Welsh RM, Adams EH, et al. Ongoing transmission of Candida auris in health care facilities — United States, June 2016-May 2017. (Notes from the field) MMWR 2017 May 19;66(19):514-5

Vallabhaneni S, Sapiano M, Weiner LM, et al. Antifungal susceptibility testing practices at acute care hospitals enrolled in the National Healthcare Safety Network, United States, 2011-2015. Open Forum Infect Dis 2017 (published online Aug 16)

Vasquez AM, Lake J, Ngai S, et al. Fungal bloodstream infections associated with compounded intravenous medication at an outpatient oncology clinic — New York City, 2016. (Notes from the field) MMWR 2016 Nov 18;65(45):1274-5

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