H7N9 Avian Influenza

Recent News

Aug 29, 2014

Flu Scan for Aug 29, 2014

Ohio reports H3N2v case
H7N9 case in China
Aug 27, 2014

Flu Scan for Aug 27, 2014

Reassortant H7N9 avian flu
H5N1 vaccine and versatile antibodies
Aug 18, 2014

Flu Scan for Aug 18, 2014

FDA clears flu vaccine for jet injection
H7N9 in Chinese poultry
Aug 12, 2014

Flu Scan for Aug 12, 2014

H7N9 in macaques
Flu spike in Australia
Canadian flu vaccine plant
Jul 29, 2014

Flu Scan for Jul 29, 2014

Mild H7N9 cases in kids
H10N8 in China
Global flu update
Jul 15, 2014

News Scan for Jul 15, 2014

Late-season H7N9 in bird markets
Hospice antibiotic prescribing
Jul 08, 2014

News Scan for Jul 08, 2014

50 more Ebola cases
H7N9 case in China
Mongolia measles-free
Fungal foodborne pathogen
Pneumococcal vaccine in kids
Polio vaccine ban in Afghanistan
Jul 03, 2014

News Scan for Jul 03, 2014

New MERS case
Studies on new tick-borne disease
Possible H7N9 precursor
Global TB strategy
Safe water in Syria
Jul 01, 2014

Flu Scan for Jul 01, 2014

Global flu activity
Zhejiang poultry ban
Jun 27, 2014

Reports on H7N9 clusters show limited family spread

Two reports provide some reassurance that the virus doesn't often spread among humans.

Resources & Literature

Resources

Jump to Recent Literature

 

Last updated Aug 11, 2014

Center of Excellence for Influenza Research and Surveillance (CEIRS) Resources

H7N9 PDF of epidemiologic curve, other case graphs, and map
PowerPoint slides of the H7N9 graphs and map

 

 


Latest Case Information

Frequently updated case list from FluTrackers
Graphs, charts, maps, and other info from FluTrackers
Case table and other info from Flu Wiki
Healthmap.org (search for H7N9 near top)
Disease outbreak news from WHO
Graphs, charts, maps, and other info from Virology Down Under
Google case map compiled by South China Morning Post
H7N9 infographic from Bloomberg News
Genetic analysis of virus from The Lancet (May 1, 2013)

Health Agency Documents

World Health Organization (WHO)

H7N9 page
Risk assessment (Jul 4, 2013)
H7N9 overview (May 31, 2013)
Latest case update (May 29, 2013)
Candidate vaccine viruses (May 26, 2014)
Joint mission report (May 18, 2013)
Lab guidance (May 10, 2013)
Surveillance recommendations (May 10, 2013)
Frequently asked questions (Feb 14, 2014)
Preliminary assessments of age and sex distribution (Apr 22, 2013)
RT-PCR protocol for H7N9 detection (Apr 15, 2013)
Background and summary (Apr 5, 2013)
Weekly report

US Centers for Disease Control and Prevention (CDC)

H7N9 page (updated Feb 12, 2014)
                                                                                                                           Frequently asked questions (May 14, 2014)
                                                                                                       Interim guidance on case definitions (Jan 10, 2014)
                                                                                          Study on risk factors (Jun 17, 2014)                                                                                                                    Top 10 pandemic response planning tips (May 30, 2013)
                                                                                   Emergence of avian influenza A(H7N9) virus causing severe human illness (May 10, 2013)                     Information for travelers to China (updated Aug 4, 2014)
                                                                               Interim guidance for healthcare professionals (Jan 23, 2014)                                                                       Interim antiviral guidance (Sep 30, 2013)                                                                                                             Interim guidance on chemoprophylaxis with antiviral medications (Sep 30, 2013)                                 Testing recommendations for possible H7N9 infection in US (Jan 24, 2014)                                               H7N9 images

Department of Health and Human Services (HHS)

H7N9 page

Hong Kong Centre for Health Protection (CHP)
Avian influenza page

Weekly avian influenza report

Chinese Center for Disease Control and Prevention

H7N9 page
Daily updates
Frequently asked questions
Research highlights
Health tips for travelers

European Centre for Disease Prevention and Control (ECDC)

Risk assessment (Jan 27, 2014)
Epidemiologic update (Feb 7, 2014)
Case definition and case finding algorithm (Apr 26, 2013)
Genetic analysis from Euro Surveill (Apr 18, 2013)
Detection and clinical validation guidance from Euro Surveill (Apr 18, 2013)
Avian influenza page                                                                                                                                        Laboratory preparedness in EU/EEA for detection of H7N9 from Euro Surveill (Jan 30, 2014)

Public Health Agency of Canada (PHAC)

H7N9 page 
Travel health notice (Feb 17, 2014)
Public health notice (Aug 11, 2014)
Risk assessment (Aug 5, 2014)
Infection prevention and control guidance (Jun 24, 2013)

Biosafety advisory (Mar 17, 2014)

Public Health England (PHE)

Guidance for possible cases in travelers

World Organization for Animal Health (OIE)

Frequently asked questions
Statement on key role of live-bird markets (Apr 30, 2013)

Food and Agriculture Organization (FAO)

Frequently asked questions (May 27, 2013)
Reducing H7N9 risk with good biosecurity and hygiene (Apr 11, 2013)

American Public Health Association (APHA)

What you should know now (Apr 19, 2013 blog post)

Twitter

CIDRAP (@CIDRAP)
Helen Branswell (@HelenBranswell)
CDC: Flu (@CDCFlu)
Michael Coston (@Fla_Medic)
ECDC (@ECDC_EU)
Martin Enserink (@martinenserink)
FluTrackers.com (@FluTrackers)
Jason Gale (@jwgale)
GISAID AI Digest (@AIDigest)
Gregory Hartl (@HaertlG)
HealthMap.org (@healthmap)
Crawford Kilian (@crof)
nprGlobalHealth (@nprGlobalHealth)
Lisa Schnirring (@lisaschnirring)
Marc Sprenger (@ECDC_MSprenger)
World Health Organization (@WHO)

 

Recent Literature

Chen Z, Baz M, Lu J, et al. Development of a high yield live attenuated H7N9 influenza vaccine that provides protection against homologous and heterologous H7 wild-type viruses in ferrets. J Virol 2014 (published online Apr 9)

Chen Z, Liu H, Lu J, et al. Asymptomatic, mild, and severe influenza A(H7N9) virus infection in humans, Guangzhou, China. Emerg Infect Dis 2014 (published online Aug 14)

Chen Z, Liu H, Lu J, et al. Asymptomatic, mild, and severe influenza A(H7N9) virus infection in humans, Guangzhou, China. Emerg Infect Dis 2014 Sep;20(9)

Chowell G, Simonsen L, Towers S, et al. Transmission potential of influenza A/H7N9, February to May 2013, China. BMC Medicine 2013 (published online Oct 2)

de Wit E, Rasmussen AL, Feldmann F, et al. Influenza virus A/Anhui/1/2013 (H7N9) replicates efficiently in the upper and lower respiratory tracts of cynomolgus macaques. mBio 2014 Aug 12;5(4):e01331-14

Ding H, Xie L, Sun Z, et al. Epidemiologic characterization of 30 confirmed cases of human infection with avian influenza A(H7N9) virus in Hangzhou, China. BMC Infect Dis 2014 Mar 31;14:175

Duan Y, Gu H, Chen R, et al. Response of mice and ferrets to a monovalent influenza A (H7N9) split vaccine. PLoS One 2014 Jun 17;9(6):e99322

Fang LQ, Li XL, Liu K, et al. Mapping spread and risk of avian influenza A (H7N9) in China. Sci Rep 2013 (published online Sep 26) 

Feng Y, Mao H, Xu C, et al. Origin and characteristics of internal genes affect infectivity of the novel avian-origin influenza A (H7N9) virus. PLoS One 2013 (published online Nov 22)

Fuller T, Havers F, Xu C, et al. Identifying areas with a high risk of human infection with the avian influenza A (H7N9) virus in East Asia. J Infect 2014 (published online Mar 15)

Gabbard JD, Dlugolenski D, Van Riel D, et al. Novel H7N9 influenza virus shows low infectious dose, high growth and efficient contact transmission in the guinea pig model. J Virol 2013 (published online Nov 13) 

Gong Z, Lv H, Ding H, et al. Epidemiology of the avian influenza A (H7N9) outbreak in Zhejiang Province, China. BMC Infect Dis 2014;14:244 (published online May 8)

Hackett H, Bialasiewicz S, Jacob K, et al. Screening for H7N9 influenza A by matrix gene-based real-time reverse-transcription PCR. J Virol Methods 2013 (published online Oct 14)

Hai R, Schomolke M, Leyva-Grado VH, et al. Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibility. Nat Commun 2013 (published online Dec 10)

Han J, Liu J, Wang L, et al. Persistent detection of avian influenza A/H7N9 virus among poultry in Huzhou City, China, in the summer of 2013. Int J Infect Dis 2014 (published online Jul 14)

He Y, Liu P, Tang S, et al. Live poultry market closure and control of avian influenza A(H7N9), Shanghai, China. Emerg Infect Dis 2014 (published online Jun 10)

Hu J, Zhu Y, Zhao B, et al. Limited human-to-human transmission of avian influenza A(H7N9) virus, Shanghai, China, March to April 2013. Euro Surveill 2014 Jun 26;19(25):pii=20838

Huang F, Guo J, Zou Z, et al. Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients. Nature Comm 2014;5(3595) (published online May 6)

Ji H, Gu Q, Chen L-l, et al. Epidemiological and clinical characteristics and risk factors for death of patients with avian influenza A H7N9 virus infection from Jiangsu Province, Eastern China. PLoS One 2014 Mar 4;9(3):e89581

Jones JC, Baranovich T, Zaraket H, et al. Human H7N9 influenza viruses replicate in swine respiratory tissue explants. J Virol 2013 (published online Sep 11) 

Jones JC, Sonnberg S, Kocer ZA, et al. Possible role of songbirds and parakeets in transmission of influenza A(H7N9) virus to humans. Emerg Infect Dis 2014 (published online Jan 24)

Ke C, Lu J, Wu J, et al. Circulation of reassortant influenza A(H7N9) viruses in poultry and humans, Guangdong province, China, 2013. Emerg Infect Dis 2014 (published online Aug 27)

Knepper J, Schierhorn KL, Becher A, et al. The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue. MBio 2013 Oct 8;4(5):e00601-13 

Ku KB, Park EH, Yum J, et al. Transmissibility of novel H7N9 and H9N2 avian influenza viruses between chickens and ferrets. Virology 2014 Feb;450-1:316-23

Li Q, Zhou L, Zhou M, et al. Epidemiology of human infections with avian influenza A(H7N9) virus in China. N Engl J Med 2014 Feb 6;370(6):520-32

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