H7N9 Avian Influenza

Recent News

Sep 23, 2015

News Scan for Sep 23, 2015

MERS in Kuwait
Soft palate and flu evolution
Egyptian H5N1 cases series
Avian flu in Nigeria, Vietnam, South Africa
Flu activity down Down Under
Sep 14, 2015

News Scan for Sep 14, 2015

More Ebola in Sierra Leone
New chikungunya cases
H7N9 risk factors
Medical device sanitizing
Sep 04, 2015

News Scan for Sep 04, 2015

Market closures and H7N9 levels
H3N2v flu in Michigan
MRSA risk factors
Aug 27, 2015

Flu Scan for Aug 27, 2015

H5N1 in Ivory Coast and Nigeria
H7N9 research highlights
Global flu update
Aug 24, 2015

Avian Flu Scan for Aug 24, 2015

H5N1 in Russian birds
H7N9 evolution
Jul 22, 2015

Flu Scan for Jul 22, 2015

H7N9 vaccine and adjuvants
Broadly protective flu vaccine
H5N1 in China, Ghana
Jul 20, 2015

Avian Flu Scan for Jul 20, 2015

West Africa H5N1 alert
More H5N2 in Taiwan
WHO on H7N9 cases in China
Jul 10, 2015

Flu Scan for Jul 10, 2015

H7N9 cases in China
Influenza B lineages compared
Jun 22, 2015

Avian Flu Scan for Jun 22, 2015

Novel H5N9 virus in chickens
H5N1 in China, Israel
Jun 15, 2015

Avian Flu Scan for Jun 15, 2015

H7N9 cases in China
H5N1 in Iranian flock
H5N2 outbreaks in Taiwan

Resources & Literature


Jump to Recent Literature


Last updated Oct 8, 2014

Center of Excellence for Influenza Research and Surveillance (CEIRS) Resources

H7N9 PDF of epidemiologic curve, other case graphs, and map
PowerPoint slides of the H7N9 graphs and map



Latest Case Information

Frequently updated case list from FluTrackers
Graphs, charts, maps, and other info from FluTrackers
Case table and other info from Flu Wiki
Healthmap.org (search for H7N9 near top)
Disease outbreak news from WHO
Graphs, charts, maps, and other info from Virology Down Under
Google case map compiled by South China Morning Post
H7N9 infographic from Bloomberg News
Genetic analysis of virus from The Lancet (May 1, 2013)

Health Agency Documents

World Health Organization (WHO)

H7N9 page
Risk assessment (Jul 4, 2013)
H7N9 overview (May 31, 2013)
Latest case update (May 29, 2013)
Candidate vaccine viruses (May 26, 2014)
Joint mission report (May 18, 2013)
Lab guidance (May 10, 2013)
Surveillance recommendations (May 10, 2013)
Frequently asked questions (Feb 14, 2014)
Preliminary assessments of age and sex distribution (Apr 22, 2013)
RT-PCR protocol for H7N9 detection (Apr 15, 2013)
Background and summary (Apr 5, 2013)
Weekly report

US Centers for Disease Control and Prevention (CDC)

H7N9 page (updated Feb 12, 2014)
                                                                                                                           Frequently asked questions (Sep 9, 2014)
                                                                                                       Interim guidance on case definitions (Jan 10, 2014)
                                                                                          Study on risk factors (Jun 17, 2014)                                                                                                                    Top 10 pandemic response planning tips (May 30, 2013)
                                                                                   Emergence of avian influenza A(H7N9) virus causing severe human illness (May 10, 2013)                     Interim guidance for healthcare professionals (Jan 23, 2014)                                                                       Interim antiviral guidance (Sep 30, 2013)                                                                                                             Interim guidance on chemoprophylaxis with antiviral medications (Sep 30, 2013)                                 Testing recommendations for possible H7N9 infection in US (Jan 24, 2014)                                               H7N9 images

Department of Health and Human Services (HHS)

H7N9 page

Hong Kong Centre for Health Protection (CHP)
Avian influenza page

Weekly avian influenza report

Chinese Center for Disease Control and Prevention

H7N9 page
Daily updates
Frequently asked questions
Research highlights
Health tips for travelers

European Centre for Disease Prevention and Control (ECDC)

Risk assessment (Jan 27, 2014)
Epidemiologic update (Feb 7, 2014)
Case definition and case finding algorithm (Apr 26, 2013)
Genetic analysis from Euro Surveill (Apr 18, 2013)
Detection and clinical validation guidance from Euro Surveill (Apr 18, 2013)
Avian influenza page                                                                                                                                        Laboratory preparedness in EU/EEA for detection of H7N9 from Euro Surveill (Jan 30, 2014)

Public Health Agency of Canada (PHAC)

H7N9 page 
Travel health notice (Feb 17, 2014)
Public health notice (Oct 8, 2014)
Risk assessment (Oct 8, 2014)
Infection prevention and control guidance (Jun 24, 2013)

Biosafety advisory (Mar 17, 2014)

Public Health England (PHE)

Guidance for possible cases in travelers

World Organization for Animal Health (OIE)

Frequently asked questions
Statement on key role of live-bird markets (Apr 30, 2013)

Food and Agriculture Organization (FAO)

Frequently asked questions (May 27, 2013)

American Public Health Association (APHA)

What you should know now (Apr 19, 2013 blog post)


Helen Branswell (@HelenBranswell)
CDC: Flu (@CDCFlu)
Michael Coston (@Fla_Medic)
Martin Enserink (@martinenserink)
FluTrackers.com (@FluTrackers)
Jason Gale (@jwgale)
GISAID AI Digest (@AIDigest)
Gregory Hartl (@HaertlG)
HealthMap.org (@healthmap)
Crawford Kilian (@crof)
nprGlobalHealth (@nprGlobalHealth)
Lisa Schnirring (@lisaschnirring)
Marc Sprenger (@ECDC_MSprenger)
World Health Organization (@WHO)


Recent Literature

Chan EYY, Cheng CKY, Tam G, et al. Knowledge, attitudes, and practices of Hong Kong population towards human A/H7N9 influenza pandemic preparedness, China, 2014. BMC Public Health 2015 Sep 22;15:943

Cheng QL, Ding H, Sun Z, et al. Retrospective study of risk factors of mortality in human avian influenza A(H7N9) cases in Zhejiang Province, China, March 2013 to June 2014. Int J Infect Dis 2015 (published online Sep 13)

Cheng VCC, Tai JWM, Lee WM, et al. Infection control preparedness for human infection with influenza A H7N9 in Hong Kong. Infect Control Hosp Epidemiol 2015 Jan;36(1):87-92

Ding H, Chen Y, Yu Z, et al. A family cluster of three confirmed cases infected with avian influenza A (H7N9) virus in Zhejiang Province of China. BMC Infect Dis 2014 Dec 31;14:3846

Dunand CJH, Leon PE, Kaur K, et al. Preexisting human antibodies neutralize recently emerged H7N9 influenza strains. J Clin Invest 2015 (published online Feb 17)

FAO. Addressing avian influenza A(H7N9): guidelines for risk communication messaging. Sep 25, 2015

Farooqui A, Leon AJ, Huang L, et al. Genetic diversity of the 2013-14 human isolates of influenza H7N9 in China. BMC Infect Dis 2015 Feb 28;15:109

Feng L, Wu JT, Liu X, et al. Clinical severity of human infections with avian influenza A(H7N9) virus, China, 2013/14. Euro Surveill 2014 Dec 11;19(49):pii=20984

Jackson LA, Campbell JD, Frey SE, et al. Effect of varying doses of a monovalent H7N9 influenza vaccine with and without AS03 and MF59 adjuvants on immune response: a randomized clinical trial. JAMA 2015 Jul 21;314(3):237-46

He F, Chen EF, Li FD, et al. Human infection and environmental contamination with avian influenza A (H7N9) virus in Zhejiang Province, China: risk trend across the three waves of infection. BMC Public Health 2015 Sep 21;15:931

Hoffmann J, Otte A, Thiele S, et al. Sex differences in H7N9 influenza A virus pathogenesis. Vaccine 2015 (published online Aug 25)

Jones JC, Sonnberg S, Webby RJ, et al. Influenza A(H7N9) virus transmission between finches and poultry. Emerg Infect Dis 2015 (published online Mar 11)

Kucharski AJ, Mills HL, Donnelly CA, et al. Transmission potential of influenza A(H7N9) virus, China, 2013-2014. Emerg Infect Dis 2015 (published online Apr 1)

Leung Y, To M, Lam T, et al. Epidemiology of human influenza A(H7N9) infection in Hong Kong. J Microbiol Immunol Infect 2015 (published online Jul 25)

Ma MJ, Ma GY, Yang XX, et al. Avian influenza A(H7N9) virus antibodies in close contacts of infected persons, China, 2013-2014. Emerg Infect Dis 2014 (published online Dec 23)

Marjuki H, Mishin VP, Chesnokov AP, et al. Characterization of drug-resistant influenza A(H7N9) variants isolated from an oseltamivir-treated patient in Taiwan. J Infect Dis 2015 Jan 15;211(2):249-57

Millman AJ, Havers F, Iuliano AD, et al. Detecting spread of avian influenza A(H7N9) virus beyond China. Emerg Infect Dis 2015 (published online Apr 6)

Pu J, Wang S, Yin Y, et al. Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus. Proc Natl Acad Sci 2014 (published online Dec 29)

Qin Y, Horby PW, Tsang TK, et al. Differences in the epidemiology of human cases of avian influenza A(H7N9) and A(H5N1) viruses infection. Clin Infect Dis 2015 (published online May 4)

Shi D, Shen S, Gan X, et al. Evaluation of commercial diagnostic assays for the specific detection of avian influenza A(H7N9) virus RNA using a quality-control panel and clinical specimens in China. PLoS One 2015 (published online Sep 11)

Skowronski DM, Chambers C, Gustafson R, et al. Avian influenza A(H7N9) virus infection in 2 travelers returning from China to Canada, January 2015. Emerg Infect Dis 2015 (published online Sep 25)

Spackman E, Pantin-Jackwood M, Swayne DE, et al. Impact of route of exposure and challenge dose on the pathogenesis of H7N9 low pathogenicity avian influenza virus in chickens. Virology 2015 Mar;477:72-81

Terajima M, Co MDT, Cruz J, et al. High antibody-dependent cellular cytotoxicity antibody titers to H5N1 and H7N9 avian influenza A viruses in healthy US adults and older children. J Infect Dis 2015 (published online Mar 20)

Wang X, Liu S, Mao H, et al. Surveillance of avian H7N9 virus in various environments of Zhejiang Province, China before and after live poultry markets were closed in 2013-2014. PLoS One 2015 Aug 26;10(8):e0135718

Wong SS, Kaplan B, Zanin M, et al. Impact of adjuvants on the immunogenicity and efficacy of split-virion H7N9 vaccine in ferrets. J Infect Dis 2015 (published online Feb 23)

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