MCR-1

Mobilized colistin resistance gene

Recent News

Sep 11, 2018
Endoscopy

Report ties 2 US cases of MCR-1 to problematic GI scope

The two patients shared exposure to a duodenoscope used in endoscopy.

Aug 15, 2018

Stewardship / Resistance Scan for Aug 15, 2018

MCR-3 in English pigs
ESBL E coli in Europe
Jul 25, 2018

Stewardship / Resistance Scan for Jul 25, 2018

Antibiotic resistance in leeches
Candida auris uptick
MCR-1 on hospital surfaces
Jul 18, 2018

Stewardship / Resistance Scan for Jul 18, 2018

Best antibiotic practices for farms
Colistin resistance and MCR-1
Antibiotic persistence in goat's milk
May 25, 2018

News Scan for May 25, 2018

Nipah virus in India
Salmonella and kratom
New US pediatric flu death
MCR-1, MCR-3 in Korea
Polio in Nigeria
May 23, 2018

Stewardship / Resistance Scan for May 23, 2018

NDM plus MCR-1 in E coli
C diff and sharps containers
May 14, 2018
Free-range chickens

Chinese scientists find 2 MCR genes on same plasmid

Similar plasmids were found in a hospitalized patient and in hospital sewage.

Apr 30, 2018

Stewardship / Resistance Scan for Apr 30, 2018

Stewardship in primary care
Variant MCR-3 gene
Resistant H pylori in Africa
Apr 18, 2018

Stewardship / Resistance Scan for Apr 18, 2018

New colistin resistance gene
More MCR-1 in China
E coli in Iranian dairy products
Apr 03, 2018

Stewardship / Resistance Scan for Apr 03, 2018

Global spread of MCR gene
CARB-X diagnostics funding
Antibiotics and kids' allergies

Resources & Literature

Recent Literature

Belaynehe KM, Shin SW, Park KY, et al. Emergence of mcr-1 and mcr-3 variants coding for plasmid-mediated colistin resistance in Escherichia coli isolates from food-producing animals in South Korea. Int J Infect Dis 2018 (published online May 24)

Carattoli A, Carretto E, Brovarone F, et al. Comparative analysis of mcr-4 Salmonella enterica subsp. enterica monophasic variant of human and animal origin. J Antimicrob Chemother 2018 (published online Aug 22)

Carretto E, Brovarone F, Nardini P, et al. Detection of mcr-4 positive Salmonella enterica serovar Typhimurium in clinical isolates of human origin, Italy, October to November 2016. Euro Surveill 2018 Jan 11;23(2):pii=17-00821

Caselli E, D'Accolti M, Soffritti I, et al. Spread of mcr-1–driven colistin resistance on hospital surfaces, Italy. (Research letter) Emerg Infect Dis 2018 (published online Jul 23)

Chan WS, Au CH, Ho DN, et al. Prospective study on human fecal carriage of Enterobacteriaceae possessing mcr-1 and mcr-2 genes in a regional hospital in Hong Kong. BMC Infect Dis 2018 Feb 13;18:81

Chavda B, Lv J, Hou M, et al. Coidentification of mcr-4.3 and blaNDM-1 in a clinical Enterobacter cloacae isolate from China. Antimicrob Agents Chemother 2018 Oct;62(10)

Chavda B, Lv J, Hou M, et al. The co-identification of mcr-4.6 and blaNDM-1 in a clinical Enterobacter cloacae isolate from China. Antimicrob Agents Chemother 2018 (published online Jul 23)

Fernandes MR, Cerdeira L, Silva MM, et al. Novel mcr-5.3 variant in a CTX-M-8-producing Escherichia coli ST711 isolated from an infected horse. J Antimicrob Chemother 2018 (published online Sep 7)

Hmede Z, Kassem II. The colistin resistance gene, mcr-1, is prevalent in commensal E. coli isolated from Lebanese pre-harvest poultry. Antimicrob Agents Chemother 2018 (published online Aug 27)

Li Y, Lin X, Yao X, et al. Synergistic antimicrobial activity of colistin in combination with rifampin and azithromycin against Escherichia coli producing MCR-1. Antimicrob Agents Chemother 2018 (published online Sep 17)

Liu X, Wang Y, Cui L, et al. A retrospective study on mcr-1 in clinical Escherichia coli and Klebsiella pneumoniae isolates in China from 2007 to 2016. J Antimicrob Chemother 2018 (published online Apr 17)

Lv L, Zeng Z, Song Q, et al. Emergence of XDR Escherichia coli carrying both blaNDM and mcr-1 genes in chickens at slaughter and the characterization of two novel blaNDM-bearing plasmids. J Antimicrob Chemother 2018 (published online May 22)

Ma S, Sun C, Hulth A, et al. Mobile colistin resistance gene mcr-5 in porcine Aeromonas hydrophila. J Antimicrob Chemother 2018 (published online Apr 11)

Mavrici D, Yambao JC, Lee BG, et al. Screening for the presence of mcr-1/mcr-2 genes in Shiga toxin-producing Escherichia coli recovered from a major produce-production region in California. PLoS One 2017 Nov 8;12(11):e0187827

Mendes AC, Novais A, Camps J, et al. mcr-1 in carbapenemase-producing Klebsiella pneumoniae with hospitalized patients, Portugal, 2016-2017. Emerg Infect Dis 2018 (published online Mar 5)

Meunier D, Woodford N, Hopkins KL. Evaluation of the AusDiagnostics MT CRE EU assay for the detection of carbapenemase genes and transferable colistin resistance determinants mcr-1/-2 in MDR gram-negative bacteria. J Antimicrob Chemother 2018 (published online Sep 5)

Nang SC, Morris FC, McDonald MJ, et al. Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae. J Antimicrob Chemother 2018 (published online Mar 5)

peptide-conjugated phosphorodiamidate morpholino oligomers restores sensitivity to polymyxin in Escherichia coli. mBio 2017 Nov 7;8(6):e01315-17

Rebelo AR, Bortolaia V, Kjeldgaard JS, et al. Multiplex PCR for detection of plasmid-mediated colistin resistance determinants, mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 for surveillance purposes. Euro Surveill 2018 Feb 8;23(6):pii=17-00672

Shenoy ES, Pierce VM, Walters MS, et al. Transmission of mobile colistin resistance (mcr-1) by duodenoscope. Clin Infect Dis 2018 (published online Sep 11)

Snesrud E, Maybank R, Kwak YI, et al. Chromosomally encoded mcr-5 in colistin non-susceptible Pseudomonas aeruginosa. Antimicrob Agents Chemother 2018 (published online May 29)

Wang R, van Dorp L, Shaw L, et al. The global distribution and spread of the mobilized colistin resistance gene mcr-1. bioRxiv 2017 Nov 17

Wangchinda W, Pati N, Maknakhon N, et al. Collateral damage of using colistin in hospitalized patients on emergence of colistin-resistant Escherichia coli and Klebsiella pneumoniae colonization and infection. Antimicrob Resist Infect Control 2018 Jul 17;7:84

Wise MG, Estabrook MA, Sahm DF, et al. Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program. PLoS One 2018 Apr 2;13(4):e0195281

Xiang R, Liu BH, Zhang AY, et al. Co-location of the polmyxin resistance gene mcr-1 and variant of mcr-3 on a plasmid in Escherichia coli from chicken farm. Antimicrob Agents Chemother 2018 (published online May 14)

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