Mobilized colistin resistance gene

Recent News

Apr 18, 2018

Stewardship / Resistance Scan for Apr 18, 2018

New colistin resistance gene
More MCR-1 in China
E coli in Iranian dairy products
Apr 03, 2018

Stewardship / Resistance Scan for Apr 03, 2018

Global spread of MCR gene
CARB-X diagnostics funding
Antibiotics and kids' allergies
Mar 15, 2018

Stewardship / Resistance Scan for Mar 15, 2018

MCR-4, MCR-5 in China
Award for blood infection test
Antibiotics and Staph biofilms
Mar 06, 2018

Stewardship / Resistance Scan for Mar 06, 2018

MCR-1, CPE in Portugal
New CARB-X funding
Mar 05, 2018
Sepsis or bacteremia

Australian report shows rise in resistant E coli bacteremia

Fluoroquinolone resistance in hospital-onset E coli bacteremia rose markedly.

Mar 02, 2018
Drug-resistant Shigella

MCR-1-carrying Shigella found in China

The authors say that finding MCR-1 in Shigella flexneri from pig feces suggests it could be circulating on Chinese farms and beyond.

Feb 14, 2018

Stewardship / Resistance Scan for Feb 14, 2018

MCR-1 in Italy, Hong Kong
Fast track for ESBL inhibitor
MDR-TB drug combo
Jan 11, 2018

Stewardship / Resistance Scan for Jan 11, 2018

MCR-4 in humans
Antibiotics in early pregnancy
Nasal screen for MRSA pneumonia
Nov 20, 2017
DNA molecules

Study describes emergence, spread of MCR-1 gene

Isolates shared a background that took shape in 2006, when MCR-1 was first mobilized.

Nov 09, 2017

Stewardship / Resistance Scan for Nov 09, 2017

Antibiotics and subsequent sepsis
MCR surveillance in California

Resources & Literature

Recent Literature

Carattoli A, Villa L, Feudi C, et al. Novel plasmid-mediated colistin resistance mcr-4 gene in Salmonella and Escherichia coli, Italy 2013, Spain and Belgium, 2015 to 2016. Euro Surveill 2017 Aug 3;22(31):pii=30589

Carretto E, Brovarone F, Nardini P, et al. Detection of mcr-4 positive Salmonella enterica serovar Typhimurium in clinical isolates of human origin, Italy, October to November 2016. Euro Surveill 2018 Jan 11;23(2):pii=17-00821

Chan WS, Au CH, Ho DN, et al. Prospective study on human fecal carriage of Enterobacteriaceae possessing mcr-1 and mcr-2 genes in a regional hospital in Hong Kong. BMC Infect Dis 2018 Feb 13;18:81

Chen K, Chan EWC, Xie M, et al. Widespread distribution of mcr-1-bearing bacteria in the ecosystem, 2015 to 2016. Euro Surveill 2017 Sep 28;22(39):pii=17-00206

Ellem JA, Ginn AN, Chen SCA, et al. Locally acquired mcr-1 in Escherichia coli, Australia, 2011 and 2013. Emerg Infect Dis 2017 (published online May 23)

Hernandez M, Iglesias MR, Rodriguez-Lazaro D, et al. Co-occurrence of colistin-resistance genes mcr-1 and mcr-3 among multidrug-resistant Escherichia coli isolated from cattle, Spain, September 2015. Euro Surveill 2017 Aug 3;22(31):pii=30586

Huang TD, Bogaerts P, Berhin C, et al. Increasing proportion of carbapenemase-producing Enterobacteriaceae and emergence of a MCR-1 producer through a multicentric study among hospital-based and private laboratories in Belgium from September to November 2015. Euro Surveill 2017 May 11;22(19):pii=30530

Litrup E, Kiil K, Hammerum AM, et al. Plasmid-borne colistin resistance gene mcr-3 in Salmonella isolates from human infections, Denmark, 2009-17. Euro Surveill 2017 Aug 3;22(31):pii=30587

Mavrici D, Yambao JC, Lee BG, et al. Screening for the presence of mcr-1/mcr-2 genes in Shiga toxin-producing Escherichia coli recovered from a major produce-production region in California. PLoS One 2017 Nov 8;12(11):e0187827

Mendes AC, Novais A, Camps J, et al. mcr-1 in carbapenemase-producing Klebsiella pneumoniae with hospitalized patients, Portugal, 2016-2017. Emerg Infect Dis 2018 (published online Mar 5)

Nang SC, Morris FC, McDonald MJ, et al. Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae. J Antimicrob Chemother 2018 (published online Mar 5)

peptide-conjugated phosphorodiamidate morpholino oligomers restores sensitivity to polymyxin in Escherichia coli. mBio 2017 Nov 7;8(6):e01315-17

Rebelo AR, Bortolaia V, Kjeldgaard JS, et al. Multiplex PCR for detection of plasmid-mediated colistin resistance determinants, mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 for surveillance purposes. Euro Surveill 2018 Feb 8;23(6):pii=17-00672

Roer L, Hansen F, Stegger M, et al.  Novel mcr-3 variant, encoding mobile colistin resistance, in an ST131 Escherichia coli isolate from bloodstream infection, Denmark, 2014. Euro Surveill 2017 Aug 3;22(31):pii-30584

Schrauwen EJA, Huizinga P, van Spreuwel N, et al. High prevalence of the mcr-1 gene in retail chicken meat in the Netherlands in 2015. Antimicrob Resist Infect Control 2017 Aug 18;6:83

Tacao M, dos Santos Tavares R, Teixeira P, et al. mcr-1 and blakpc-3 in Escherichia coli sequence type 744 after meropenem and colistin therapy, Portugal. (Letter) Emerg Infect Dis 2017 (published online Jun 30)

Tada T, Uechi K, Nakasone I, et al. Emergence of a colistin-resistant Escherichia coli clinical isolate harboring mcr-1 in Japan. Int J Infect Dis 2017 (published online Aug 2)

Tian GB, Doi Y, Shen J, et al. MCR-1-producing Klebsiella pneumoniae outbreak in China. (Letter) Lancet Infect Dis 2017 Jun;17(6):577

Venditti C, Nisii C, D'Arezzo S, et al. Surveillance of mcr-1 and mcr-2 genes in Carbapenem-resistant Klebsiella pneumoniae strains from an Italian Hospital. (Letter) Euro Surveill 2017 Aug 31;22(35):pii=30604

Wang R, van Dorp L, Shaw L, et al. The global distribution and spread of the mobilized colistin resistance gene mcr-1. bioRxiv 2017 Nov 17

Wise MG, Estabrook MA, Sahm DF, et l. Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program. PLoS One 2018 Apr 2;13(4):e0195281


Yin W, Li H, Shen Y, et al. Novel plasmid-mediated colistin resistance gene mcr-3 in Escherichia coli. mBio 2017 Jun 27;8(3):e00543-17

Zhong LL, Phan HTT, Shen C, et al. High rates of human fecal carriage of mcr-1-positive multi-drug resistant Enterobacteriaceae isolates emerge in China in association with successful plasmid families. Clin Infect Dis 2017 (published online Oct 10)

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