MCR-1

Mobilized colistin resistance gene

Recent News

Nov 09, 2017

Stewardship / Resistance Scan for Nov 09, 2017

Antibiotics and subsequent sepsis
MCR surveillance in California
Oct 10, 2017

Stewardship / Resistance Scan for Oct 10, 2017

MCR-1 in US, China patients
MDROs in nursing homes
Infections in African kids
Sep 29, 2017
E coli on lettuce

Study finds MCR-1 is widespread in Chinese ecosystem

Transmission chain mapping points to prolonged colistin use in livestock and poultry.

Aug 21, 2017

Stewardship / Resistance Scan for Aug 21, 2017

MCR-1 in Dutch chicken
Residents' prescribing
Trial for new antimalarial
Alternatives to carbapenems
Aug 03, 2017
Pipetting for DNA testing

More colistin-resistance genes identified in Europe

Scientists report the first detection of MCR-4, as well as MCR-3 in Denmark and Italy.

Jul 26, 2017

Stewardship / Resistance Scan for Jul 26, 2017

New antibiotics class
Triple-drug combo for MCR-1 & NDM-5
US MRSA trends
Jun 30, 2017

Stewardship / Resistance Scan for Jun 30, 2017

Students' antibiotic knowledge
MCR-1 in Portugal
Jun 28, 2017
Pig closeup

New colistin resistance gene identified in China

The authors of the study say they're concerned the gene may already be widely disseminated.

Jun 27, 2017

News Scan for Jun 27, 2017

Antibiotic resistance at the Hajj
MERS in Riyadh
Plague cases
Cat-linked tularemia case
HPV vaccine impact
H5N8 in Belgium
May 25, 2017
Asian boy in hospital

Hospital outbreak of MCR-1 Klebsiella reported in China

Scientists say it's the first MCR-1 hospital outbreak.

Resources & Literature

Recent Literature

Carattoli A, Villa L, Feudi C, et al. Novel plasmid-mediated colistin resistance mcr-4 gene in Salmonella and Escherichia coli, Italy 2013, Spain and Belgium, 2015 to 2016. Euro Surveill 2017 Aug 3;22(31):pii=30589

Caspar Y, Maillet M, Pavese P, et al. Mcr-1 colistin resistance in ESBL-producing Klebsiella pneumoniae, France. (Letter) Emerg Infect Dis 2017 (published online April 17)

Chen K, Chan EWC, Xie M, et al. Widespread distribution of mcr-1-bearing bacteria in the ecosystem, 2015 to 2016. Euro Surveill 2017 Sep 28;22(39):pii=17-00206

Corbella M, Mariani B, Ferrari C, et al. Three cases of mcr-1-positive colistin-resistant Escherichia coli bloodstream infections in Italy, August 2016 to January 2017. Euro Surveill 2017 Apr 207;22(16):pii=30517

do Monte DFM, Mem A, Fernandes MR, et al. Chicken meat as reservoir of colistin-resistant Escherichia coli carrying mcr-1 genes in South America. Antimcrob Agents Chemother 2017 (published online Feb 13)

Ellem JA, Ginn AN, Chen SCA, et al. Locally acquired mcr-1 in Escherichia coli, Australia, 2011 and 2013. Emerg Infect Dis 2017 (published online May 23)

Hernandez M, Iglesias MR, Rodriguez-Lazaro D, et al. Co-occurrence of colistin-resistance genes mcr-1 and mcr-3 among multidrug-resistant Escherichia coli isolated from cattle, Spain, September 2015. Euro Surveill 2017 Aug 3;22(31):pii=30586

Huang TD, Bogaerts P, Berhin C, et al. Increasing proportion of carbapenemase-producing Enterobacteriaceae and emergence of a MCR-1 producer through a multicentric study among hospital-based and private laboratories in Belgium from September to November 2015. Euro Surveill 2017 May 11;22(19):pii=30530

Lei L, Wang Y, Schwarz S, et al. Mcr-1 in enterobacteriaceae from companion animals, Beijing, China, 2012-2016. Emerg Infect Dis 2017 (published online Mar 16)

Litrup E, Kiil K, Hammerum AM, et al. Plasmid-borne colistin resistance gene mcr-3 in Salmonella isolates from human infections, Denmark, 2009-17. Euro Surveill 2017 Aug 3;22(31):pii=30587

Mavrici D, Yambao JC, Lee BG, et al. Screening for the presence of mcr-1/mcr-2 genes in Shiga toxin-producing Escherichia coli recovered from a major produce-production region in California. PLoS One 2017 Nov 8;12(11):e0187827

peptide-conjugated phosphorodiamidate morpholino oligomers restores sensitivity to polymyxin in Escherichia coli. mBio 2017 Nov 7;8(6):e01315-17

Quan J, Li X, Chen Y, et al. Prevalence of mcr-1 in Escherichia coli and Klebsiella pneumoniae recovered from bloodstream infections in China: a multicentre longitudinal study. Lancet Infect Dis 2017 (published online Jan 27)

Roer L, Hansen F, Stegger M, et al.  Novel mcr-3 variant, encoding mobile colistin resistance, in an ST131 Escherichia coli isolate from bloodstream infection, Denmark, 2014. Euro Surveill 2017 Aug 3;22(31):pii-30584

Schrauwen EJA, Huizinga P, van Spreuwel N, et al. High prevalence of the mcr-1 gene in retail chicken meat in the Netherlands in 2015. Antimicrob Resist Infect Control 2017 Aug 18;6:83

Stokes JM, MacNair CR, Ilyas B, et al. Pentamidine sensitizes gram-negative pathogens to antibiotics and overcomes acquired colistin resistance. Nat Microbiol 2017 (published online Mar 6)

Tacao M, dos Santos Tavares R, Teixeira P, et al. mcr-1 and blakpc-3 in Escherichia coli sequence type 744 after meropenem and colistin therapy, Portugal. (Letter) Emerg Infect Dis 2017 (published online Jun 30)

Tada T, Uechi K, Nakasone I, et al. Emergence of a colistin-resistant Escherichia coli clinical isolate harboring mcr-1 in Japan. Int J Infect Dis 2017 (published online Aug 2)

Tian GB, Doi Y, Shen J, et al. MCR-1-producing Klebsiella pneumoniae outbreak in China. (Letter) Lancet Infect Dis 2017 Jun;17(6):577

Trung N, Matamoros S, Carrique-Mas JJ, et al. Zoonotic transmission of mcr-1 colistin resistance gene from small-scale poultry farms, Vietnam. Emerg Infect Dis 2017 (published online Feb 17)

Venditti C, Nisii C, D'Arezzo S, et al. Surveillance of mcr-1 and mcr-2 genes in Carbapenem-resistant Klebsiella pneumoniae strains from an Italian Hospital. (Letter) Euro Surveill 2017 Aug 31;22(35):pii=30604

Yi L, Wang J, Gao Y, et al. Mcr-1−harboring Salmonella enterica serovar Typhimurium sequence type 34 in pigs, China. Emerg Infect Dis 2017 (published online Jan 17)

Yin W, Li H, Shen Y, et al. Novel plasmid-mediated colistin resistance gene mcr-3 in Escherichia coli. mBio 2017 Jun 27;8(3):e00543-17

Zhong LL, Phan HTT, Huang X, et al. High rates of human faecal carriage of mcr-1-positive multi-drug resistant isolates emerge in China in association with successful plasmid families. bioRxiv 2017 Feb 7

Zhong LL, Phan HTT, Shen C, et al. High rates of human fecal carriage of mcr-1-positive multi-drug resistant Enterobacteriaceae isolates emerge in China in association with successful plasmid families. Clin Infect Dis 2017 (published online Oct 10)

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