MCR-1

Mobilized colistin resistance gene

Recent News

Mar 13, 2019

Stewardship / Resistance Scan for Mar 13, 2019

Antibiotics for citrus trees
Origins of MCR-1 in France
Feb 22, 2019

Stewardship / Resistance Scan for Feb 22, 2019

Antibiotic Rx for skin infections
MCR-1, MCR-3 hybrid E coli
Jan 10, 2019

Stewardship / Resistance Scan for Jan 10, 2019

MCR-1 in Wyoming
CDC alert over Mexico infections
Jan 03, 2019

Stewardship / Resistance Scan for Jan 03, 2019

Novartis shares antibiotic data
New CARB-X funding
MCR-1 genes in food
Risk factors for resistant UTIs
Nov 08, 2018

Stewardship / Resistance Scan for Nov 08, 2018

Drug-resistant Shigella in Vermont
Deadly MDR infections in India
MCR-1 prevalence in Bolivia
MRSA in refugees
Oct 31, 2018

Stewardship / Resistance Scan for Oct 31, 2018

Antibiotics for COPD
MCR resistance genes in Vietnam
Cefto-tazo for MDR Pseudomonas
Sep 11, 2018
Endoscopy

Report ties 2 US cases of MCR-1 to problematic GI scope

The two patients shared exposure to a duodenoscope used in endoscopy.

Aug 15, 2018

Stewardship / Resistance Scan for Aug 15, 2018

MCR-3 in English pigs
ESBL E coli in Europe
Jul 25, 2018

Stewardship / Resistance Scan for Jul 25, 2018

Antibiotic resistance in leeches
Candida auris uptick
MCR-1 on hospital surfaces
Jul 18, 2018

Stewardship / Resistance Scan for Jul 18, 2018

Best antibiotic practices for farms
Colistin resistance and MCR-1
Antibiotic persistence in goat's milk

Resources & Literature

Recent Literature

Belaynehe KM, Shin SW, Park KY, et al. Emergence of mcr-1 and mcr-3 variants coding for plasmid-mediated colistin resistance in Escherichia coli isolates from food-producing animals in South Korea. Int J Infect Dis 2018 (published online May 24)

Bourrel AS, Poirel L, Royer G, et al. Colistin resistance in Parisian inpatient faecal Escherichia coli as the result of two distinct evolutionary pathways. J Antimicrob Chemother 2019 (published online Mar 12)

Carattoli A, Carretto E, Brovarone F, et al. Comparative analysis of mcr-4 Salmonella enterica subsp. enterica monophasic variant of human and animal origin. J Antimicrob Chemother 2018 (published online Aug 22)

Caselli E, D'Accolti M, Soffritti I, et al. Spread of mcr-1–driven colistin resistance on hospital surfaces, Italy. (Research letter) Emerg Infect Dis 2018 (published online Jul 23)

Chavda B, Lv J, Hou M, et al. Coidentification of mcr-4.3 and blaNDM-1 in a clinical Enterobacter cloacae isolate from China. Antimicrob Agents Chemother 2018 Oct;62(10)

Chavda B, Lv J, Hou M, et al. The co-identification of mcr-4.6 and blaNDM-1 in a clinical Enterobacter cloacae isolate from China. Antimicrob Agents Chemother 2018 (published online Jul 23)

Dalmolin TV, Wink PL, de Lima-Morales D, et al. Low prevalence of the mcr-1 gene among carbapenemase-producing clinical isolates of Enterobacterales. Infect Control Hosp Epidemiol 2018 (published online Nov 23)

Fernandes MR, Cerdeira L, Silva MM, et al. Novel mcr-5.3 variant in a CTX-M-8-producing Escherichia coli ST711 isolated from an infected horse. J Antimicrob Chemother 2018 (published online Sep 7)

Giani T, Sennati S, Antonelli A, et al. High prevalence of carriage of mcr-1-positive enteric bacteria among healthy children from rural communities in the Chaco region, Bolivia, September to October 2016. Euro Surveill 2018 Nov 8;23(45):pii=1800115

Hallenberg GS, Borjesson S, Sokerya S, et al. Detection of mcr-mediated colistin resistance in Escherichia coli isolated from pigs in small-scale farms in Cambodia. Antimicrob Agents Chemother 2019 (published online Jan 14)

Hmede Z, Kassem II. The colistin resistance gene, mcr-1, is prevalent in commensal E. coli isolated from Lebanese pre-harvest poultry. Antimicrob Agents Chemother 2018 (published online Aug 27)

Hu Y, Fanning S, Gan X, et al. Salmonella harbouring the mcr-1 gene isolated from food in China between 2012 and 2016. J Antimicrob Chemother 2019 (published online Jan 2)

Li Y, Lin X, Yao X, et al. Synergistic antimicrobial activity of colistin in combination with rifampin and azithromycin against Escherichia coli producing MCR-1. Antimicrob Agents Chemother 2018 (published online Sep 17)

Liu X, Wang Y, Cui L, et al. A retrospective study on mcr-1 in clinical Escherichia coli and Klebsiella pneumoniae isolates in China from 2007 to 2016. J Antimicrob Chemother 2018 (published online Apr 17)

Lv L, Zeng Z, Song Q, et al. Emergence of XDR Escherichia coli carrying both blaNDM and mcr-1 genes in chickens at slaughter and the characterization of two novel blaNDM-bearing plasmids. J Antimicrob Chemother 2018 (published online May 22)

Ma S, Sun C, Hulth A, et al. Mobile colistin resistance gene mcr-5 in porcine Aeromonas hydrophila. J Antimicrob Chemother 2018 (published online Apr 11)

Meunier D, Woodford N, Hopkins KL. Evaluation of the AusDiagnostics MT CRE EU assay for the detection of carbapenemase genes and transferable colistin resistance determinants mcr-1/-2 in MDR gram-negative bacteria. J Antimicrob Chemother 2018 (published online Sep 5)

Shenoy ES, Pierce VM, Walters MS, et al. Transmission of mobile colistin resistance (mcr-1) by duodenoscope. Clin Infect Dis 2018 (published online Sep 11)

Snesrud E, Maybank R, Kwak YI, et al. Chromosomally encoded mcr-5 in colistin non-susceptible Pseudomonas aeruginosa. Antimicrob Agents Chemother 2018 (published online May 29)

Wangchinda W, Pati N, Maknakhon N, et al. Collateral damage of using colistin in hospitalized patients on emergence of colistin-resistant Escherichia coli and Klebsiella pneumoniae colonization and infection. Antimicrob Resist Infect Control 2018 Jul 17;7:84

Wise MG, Estabrook MA, Sahm DF, et al. Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program. PLoS One 2018 Apr 2;13(4):e0195281

Xiang R, Liu BH, Zhang AY, et al. Co-location of the polmyxin resistance gene mcr-1 and variant of mcr-3 on a plasmid in Escherichia coli from chicken farm. Antimicrob Agents Chemother 2018 (published online May 14)

Yang YQ, Li YX, Lei CW, et al. Novel plasmid-mediated colistin resistance gene mcr-7.1 in Klebsiella pneumoniae. J  Antimicrob Chemother 2018 (published online Apr 17)

Yu Y, Walsh TR, Yang RS, et al. Novel partners with colistin to increase its in vivo therapeutic effectiveness and prevent the occurrence of colistin resistance in NDM- and MCR-co-producing Escherichia coli in a murine infections model. J Antimicrob Chemother 2018 (published online Oct 20)

Zhang J, Zhao D, Quan J, et al. mcr-1 facilitated selection of high-level colistin resistant mutants in Escherichia coli. Clin Microbiol Infect 2018 (published online Dec 14)

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