MCR-1

Mobilized colistin resistance gene

Recent News

Jan 11, 2018

Stewardship / Resistance Scan for Jan 11, 2018

MCR-4 in humans
Antibiotics in early pregnancy
Nasal screen for MRSA pneumonia
Nov 20, 2017
DNA molecules

Study describes emergence, spread of MCR-1 gene

Isolates shared a background that took shape in 2006, when MCR-1 was first mobilized.

Nov 09, 2017

Stewardship / Resistance Scan for Nov 09, 2017

Antibiotics and subsequent sepsis
MCR surveillance in California
Oct 10, 2017

Stewardship / Resistance Scan for Oct 10, 2017

MCR-1 in US, China patients
MDROs in nursing homes
Infections in African kids
Sep 29, 2017
E coli on lettuce

Study finds MCR-1 is widespread in Chinese ecosystem

Transmission chain mapping points to prolonged colistin use in livestock and poultry.

Aug 21, 2017

Stewardship / Resistance Scan for Aug 21, 2017

MCR-1 in Dutch chicken
Residents' prescribing
Trial for new antimalarial
Alternatives to carbapenems
Aug 03, 2017
Pipetting for DNA testing

More colistin-resistance genes identified in Europe

Scientists report the first detection of MCR-4, as well as MCR-3 in Denmark and Italy.

Jul 26, 2017

Stewardship / Resistance Scan for Jul 26, 2017

New antibiotics class
Triple-drug combo for MCR-1 & NDM-5
US MRSA trends
Jun 30, 2017

Stewardship / Resistance Scan for Jun 30, 2017

Students' antibiotic knowledge
MCR-1 in Portugal
Jun 28, 2017
Pig closeup

New colistin resistance gene identified in China

The authors of the study say they're concerned the gene may already be widely disseminated.

Resources & Literature

Recent Literature

Carattoli A, Villa L, Feudi C, et al. Novel plasmid-mediated colistin resistance mcr-4 gene in Salmonella and Escherichia coli, Italy 2013, Spain and Belgium, 2015 to 2016. Euro Surveill 2017 Aug 3;22(31):pii=30589

Carretto E, Brovarone F, Nardini P, et al. Detection of mcr-4 positive Salmonella enterica serovar Typhimurium in clinical isolates of human origin, Italy, October to November 2016. Euro Surveill 2018 Jan 11;23(2):pii=17-00821

Caspar Y, Maillet M, Pavese P, et al. Mcr-1 colistin resistance in ESBL-producing Klebsiella pneumoniae, France. (Letter) Emerg Infect Dis 2017 (published online April 17)

Chen K, Chan EWC, Xie M, et al. Widespread distribution of mcr-1-bearing bacteria in the ecosystem, 2015 to 2016. Euro Surveill 2017 Sep 28;22(39):pii=17-00206

Corbella M, Mariani B, Ferrari C, et al. Three cases of mcr-1-positive colistin-resistant Escherichia coli bloodstream infections in Italy, August 2016 to January 2017. Euro Surveill 2017 Apr 207;22(16):pii=30517

do Monte DFM, Mem A, Fernandes MR, et al. Chicken meat as reservoir of colistin-resistant Escherichia coli carrying mcr-1 genes in South America. Antimcrob Agents Chemother 2017 (published online Feb 13)

Ellem JA, Ginn AN, Chen SCA, et al. Locally acquired mcr-1 in Escherichia coli, Australia, 2011 and 2013. Emerg Infect Dis 2017 (published online May 23)

Hernandez M, Iglesias MR, Rodriguez-Lazaro D, et al. Co-occurrence of colistin-resistance genes mcr-1 and mcr-3 among multidrug-resistant Escherichia coli isolated from cattle, Spain, September 2015. Euro Surveill 2017 Aug 3;22(31):pii=30586

Huang TD, Bogaerts P, Berhin C, et al. Increasing proportion of carbapenemase-producing Enterobacteriaceae and emergence of a MCR-1 producer through a multicentric study among hospital-based and private laboratories in Belgium from September to November 2015. Euro Surveill 2017 May 11;22(19):pii=30530

Lei L, Wang Y, Schwarz S, et al. Mcr-1 in enterobacteriaceae from companion animals, Beijing, China, 2012-2016. Emerg Infect Dis 2017 (published online Mar 16)

Litrup E, Kiil K, Hammerum AM, et al. Plasmid-borne colistin resistance gene mcr-3 in Salmonella isolates from human infections, Denmark, 2009-17. Euro Surveill 2017 Aug 3;22(31):pii=30587

Mavrici D, Yambao JC, Lee BG, et al. Screening for the presence of mcr-1/mcr-2 genes in Shiga toxin-producing Escherichia coli recovered from a major produce-production region in California. PLoS One 2017 Nov 8;12(11):e0187827

peptide-conjugated phosphorodiamidate morpholino oligomers restores sensitivity to polymyxin in Escherichia coli. mBio 2017 Nov 7;8(6):e01315-17

Quan J, Li X, Chen Y, et al. Prevalence of mcr-1 in Escherichia coli and Klebsiella pneumoniae recovered from bloodstream infections in China: a multicentre longitudinal study. Lancet Infect Dis 2017 (published online Jan 27)

Roer L, Hansen F, Stegger M, et al.  Novel mcr-3 variant, encoding mobile colistin resistance, in an ST131 Escherichia coli isolate from bloodstream infection, Denmark, 2014. Euro Surveill 2017 Aug 3;22(31):pii-30584

Schrauwen EJA, Huizinga P, van Spreuwel N, et al. High prevalence of the mcr-1 gene in retail chicken meat in the Netherlands in 2015. Antimicrob Resist Infect Control 2017 Aug 18;6:83

Stokes JM, MacNair CR, Ilyas B, et al. Pentamidine sensitizes gram-negative pathogens to antibiotics and overcomes acquired colistin resistance. Nat Microbiol 2017 (published online Mar 6)

Tacao M, dos Santos Tavares R, Teixeira P, et al. mcr-1 and blakpc-3 in Escherichia coli sequence type 744 after meropenem and colistin therapy, Portugal. (Letter) Emerg Infect Dis 2017 (published online Jun 30)

Tada T, Uechi K, Nakasone I, et al. Emergence of a colistin-resistant Escherichia coli clinical isolate harboring mcr-1 in Japan. Int J Infect Dis 2017 (published online Aug 2)

Tian GB, Doi Y, Shen J, et al. MCR-1-producing Klebsiella pneumoniae outbreak in China. (Letter) Lancet Infect Dis 2017 Jun;17(6):577

Trung N, Matamoros S, Carrique-Mas JJ, et al. Zoonotic transmission of mcr-1 colistin resistance gene from small-scale poultry farms, Vietnam. Emerg Infect Dis 2017 (published online Feb 17)

Venditti C, Nisii C, D'Arezzo S, et al. Surveillance of mcr-1 and mcr-2 genes in Carbapenem-resistant Klebsiella pneumoniae strains from an Italian Hospital. (Letter) Euro Surveill 2017 Aug 31;22(35):pii=30604

Wang R, van Dorp L, Shaw L, et al. The global distribution and spread of the mobilized colistin resistance gene mcr-1. bioRxiv 2017 Nov 17

Yin W, Li H, Shen Y, et al. Novel plasmid-mediated colistin resistance gene mcr-3 in Escherichia coli. mBio 2017 Jun 27;8(3):e00543-17

Zhong LL, Phan HTT, Huang X, et al. High rates of human faecal carriage of mcr-1-positive multi-drug resistant isolates emerge in China in association with successful plasmid families. bioRxiv 2017 Feb 7

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