Mobilized colistin resistance gene

Recent News

Aug 15, 2018

Stewardship / Resistance Scan for Aug 15, 2018

MCR-3 in English pigs
ESBL E coli in Europe
Jul 25, 2018

Stewardship / Resistance Scan for Jul 25, 2018

Antibiotic resistance in leeches
Candida auris uptick
MCR-1 on hospital surfaces
Jul 18, 2018

Stewardship / Resistance Scan for Jul 18, 2018

Best antibiotic practices for farms
Colistin resistance and MCR-1
Antibiotic persistence in goat's milk
May 25, 2018

News Scan for May 25, 2018

Nipah virus in India
Salmonella and kratom
New US pediatric flu death
MCR-1, MCR-3 in Korea
Polio in Nigeria
May 23, 2018

Stewardship / Resistance Scan for May 23, 2018

NDM plus MCR-1 in E coli
C diff and sharps containers
May 14, 2018
Free-range chickens

Chinese scientists find 2 MCR genes on same plasmid

Similar plasmids were found in a hospitalized patient and in hospital sewage.

Apr 30, 2018

Stewardship / Resistance Scan for Apr 30, 2018

Stewardship in primary care
Variant MCR-3 gene
Resistant H pylori in Africa
Apr 18, 2018

Stewardship / Resistance Scan for Apr 18, 2018

New colistin resistance gene
More MCR-1 in China
E coli in Iranian dairy products
Apr 03, 2018

Stewardship / Resistance Scan for Apr 03, 2018

Global spread of MCR gene
CARB-X diagnostics funding
Antibiotics and kids' allergies
Mar 15, 2018

Stewardship / Resistance Scan for Mar 15, 2018

MCR-4, MCR-5 in China
Award for blood infection test
Antibiotics and Staph biofilms

Resources & Literature

Recent Literature

Belaynehe KM, Shin SW, Park KY, et al. Emergence of mcr-1 and mcr-3 variants coding for plasmid-mediated colistin resistance in Escherichia coli isolates from food-producing animals in South Korea. Int J Infect Dis 2018 (published online May 24)

Carretto E, Brovarone F, Nardini P, et al. Detection of mcr-4 positive Salmonella enterica serovar Typhimurium in clinical isolates of human origin, Italy, October to November 2016. Euro Surveill 2018 Jan 11;23(2):pii=17-00821

Caselli E, D'Accolti M, Soffritti I, et al. Spread of mcr-1–driven colistin resistance on hospital surfaces, Italy. (Research letter) Emerg Infect Dis 2018 (published online Jul 23)

Chan WS, Au CH, Ho DN, et al. Prospective study on human fecal carriage of Enterobacteriaceae possessing mcr-1 and mcr-2 genes in a regional hospital in Hong Kong. BMC Infect Dis 2018 Feb 13;18:81

Chavda B, Lv J, Hou M, et al. The co-identification of mcr-4.6 and blaNDM-1 in a clinical Enterobacter cloacae isolate from China. Antimicrob Agents Chemother 2018 (published online Jul 23)

Chen K, Chan EWC, Xie M, et al. Widespread distribution of mcr-1-bearing bacteria in the ecosystem, 2015 to 2016. Euro Surveill 2017 Sep 28;22(39):pii=17-00206

Liu X, Wang Y, Cui L, et al. A retrospective study on mcr-1 in clinical Escherichia coli and Klebsiella pneumoniae isolates in China from 2007 to 2016. J Antimicrob Chemother 2018 (published online Apr 17)

Lv L, Zeng Z, Song Q, et al. Emergence of XDR Escherichia coli carrying both blaNDM and mcr-1 genes in chickens at slaughter and the characterization of two novel blaNDM-bearing plasmids. J Antimicrob Chemother 2018 (published online May 22)

Ma S, Sun C, Hulth A, et al. Mobile colistin resistance gene mcr-5 in porcine Aeromonas hydrophila. J Antimicrob Chemother 2018 (published online Apr 11)

Mavrici D, Yambao JC, Lee BG, et al. Screening for the presence of mcr-1/mcr-2 genes in Shiga toxin-producing Escherichia coli recovered from a major produce-production region in California. PLoS One 2017 Nov 8;12(11):e0187827

Mendes AC, Novais A, Camps J, et al. mcr-1 in carbapenemase-producing Klebsiella pneumoniae with hospitalized patients, Portugal, 2016-2017. Emerg Infect Dis 2018 (published online Mar 5)

Nang SC, Morris FC, McDonald MJ, et al. Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae. J Antimicrob Chemother 2018 (published online Mar 5)

peptide-conjugated phosphorodiamidate morpholino oligomers restores sensitivity to polymyxin in Escherichia coli. mBio 2017 Nov 7;8(6):e01315-17

Rebelo AR, Bortolaia V, Kjeldgaard JS, et al. Multiplex PCR for detection of plasmid-mediated colistin resistance determinants, mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 for surveillance purposes. Euro Surveill 2018 Feb 8;23(6):pii=17-00672

Schrauwen EJA, Huizinga P, van Spreuwel N, et al. High prevalence of the mcr-1 gene in retail chicken meat in the Netherlands in 2015. Antimicrob Resist Infect Control 2017 Aug 18;6:83

Snesrud E, Maybank R, Kwak YI, et al. Chromosomally encoded mcr-5 in colistin non-susceptible Pseudomonas aeruginosa. Antimicrob Agents Chemother 2018 (published online May 29)

Venditti C, Nisii C, D'Arezzo S, et al. Surveillance of mcr-1 and mcr-2 genes in Carbapenem-resistant Klebsiella pneumoniae strains from an Italian Hospital. (Letter) Euro Surveill 2017 Aug 31;22(35):pii=30604

Wang R, van Dorp L, Shaw L, et al. The global distribution and spread of the mobilized colistin resistance gene mcr-1. bioRxiv 2017 Nov 17

Wangchinda W, Pati N, Maknakhon N, et al. Collateral damage of using colistin in hospitalized patients on emergence of colistin-resistant Escherichia coli and Klebsiella pneumoniae colonization and infection. Antimicrob Resist Infect Control 2018 Jul 17;7:84

Wise MG, Estabrook MA, Sahm DF, et l. Prevalence of mcr-type genes among colistin-resistant Enterobacteriaceae collected in 2014-2016 as part of the INFORM global surveillance program. PLoS One 2018 Apr 2;13(4):e0195281


Xiang R, Liu BH, Zhang AY, et al. Co-location of the polmyxin resistance gene mcr-1 and variant of mcr-3 on a plasmid in Escherichia coli from chicken farm. Antimicrob Agents Chemother 2018 (published online May 14)

Yang YQ, Li YX, Lei CW, et al. Novel plasmid-mediated colistin resistance gene mcr-7.1 in Klebsiella pneumoniae. J  Antimicrob Chemother 2018 (published online Apr 17)

Zhong LL, Phan HTT, Shen C, et al. High rates of human fecal carriage of mcr-1-positive multi-drug resistant Enterobacteriaceae isolates emerge in China in association with successful plasmid families. Clin Infect Dis 2017 (published online Oct 10)

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