MERS-CoV

Middle East respiratory syndrome coronavirus

Recent News

Sep 01, 2015
Hospital gurney

WHO confirms hospital MERS outbreak in Jordan

Also, Saudi officials reported four more cases from Riyadh, and South Korea announced new prevention steps in the wake of its outbreak.

Aug 31, 2015
Nurses station

Eleven more MERS cases in Saudi Arabia, 2 in Jordan

New reports indicate hospital MERS outbreaks in both Saudi Arabia and Jordan.

Aug 28, 2015
Blood transfusion

Riyadh, Jordan each report 2 new MERS cases

Three of the four new cases appear to involve contact with other patients, and the ECDC issues a risk assessment.

Aug 27, 2015
Respirator

Jordan reports another MERS case, Riyadh cases rise by six

In a related development, the WHO provided more details on 13 recent Saudi cases, 12 with hospital-outbreak links.

Aug 26, 2015
Jordan map

Jordan reports travel-linked MERS case, Riyadh outbreak total grows

In addition, a new WHO update details 29 recent cases from Riyadh, 24 of them connected to a large hospital outbreak.

Aug 25, 2015

News Scan for Aug 25, 2015

More MERS in Riyadh
H5N2 in Taiwan
Aug 25, 2015

ICEID News Scan for Aug 25, 2015

MERS vs SARS
Respiratory syncytial virus in the NICU
Extended flu vaccine protection
Aug 24, 2015
RiyadhMap

MERS cases from Riyadh still surging

Officials say 53 of the outbreak cases have links to one hospital and 4 involve Filipino health workers.

Aug 21, 2015
Riyadhstreetsign

MERS sickens six more in Riyadh outbreak

In other develoments, the hospital at the center of the outbreak temporarily closed most outpatient clinics to slow the spread of the virus.

Aug 20, 2015
Hajj vigil

Ten new Riyadh MERS cases as hospital ED shuttered

As Riyadh logs 10 new cases, officials announce some Hajj-related restrictions.

Resources & Literature

Resources

 

Jump to Recent Literature

 

Last updated Oct 8, 2014

Latest Cases & General Information

Frequently updated case list from FluTrackersTransmission electron micrograph of Middle East Respiratory Syndrome Coronavirus
Disease outbreak news from WHO
Maia Majumder, MPH, MERS resources on Tumblr
Virology Down Under MERS-CoV page
Naming of MERS-CoV from Science (May 6, 2013)
Genetic sequence of MERS-CoV from PHE

Health Agency Documents

World Health Organization (WHO)

MERS-CoV page 
List of latest case updates
Summary updates landing page
Latest risk assessment (Apr 24, 2014)
Frequently asked questions (May 9, 2014)
Interim Case Definitions (Jul 14, 2014)
Guidance on conducting case-control studies (Jul 15, 2014)
Interim surveillance recommendations (Jun 27, 2013)
Interim recommendations for laboratory testing (Sep 16, 2o13)
Seroepidemiological investigation of contacts (Nov 19, 2013)                                                                     Risk factors of infection among health care personnel (Jan 27, 2014)
Guidance for health care professionals (May 6, 2013)
Clinical management (Feb 11, 2013)
Home care for patients with MERS-CoV infection (Aug 8, 2013)
Travel recommendations (Jun 5, 2013)
Travel advice for pilgrims (Jun 3, 2014)
Naming of the novel coronavirus (May 28, 2013)

US Centers for Disease Control and Prevention (CDC)

MERS-CoV page
Press release on first US case
(May 2, 2014)
Press release on clearing of contacts of first 2 US cases (Jun 17, 2014)
Health Alert Network advisory (May 3, 2014)
Frequently asked questions
(Aug 4, 2014)
Case definitions (Jun 25, 2014)
Interim guidance for healthcare professionals (Jul 29, 2014)
Guidance for travelers (May 21, 2014)
Infection prevention and control guidelines (Jul 11, 2014)
Information and guidance for clinicians (Jun 18, 2013)
Guidance on air medical transport for MERS patients (Jul 3, 2014)

Interim guidance for airline crew
(Mar 10, 2014)
Guidelines for evaluation of MERS-CoV (Jun 7, 2013)                                                                                   Interim guidelines for collection, processing and transport of clinical specimens (Jun 7, 2013)          Interim guidance for preventing MERS-CoV from spreading in homes and communities (Jul 11, 2014)
Interim home care and isolation guidance for MERS-CoV (Jul 11, 2014)
Advanced molecular detection (Aug 25, 2014)
MERS-CoV Images                                                   

European Centre for Disease Prevention and Control (ECDC)

MERS-CoV page
Updated rapid risk assessment (Apr 25, 2014) 
Epidemiologic update
(May 16, 2014)

Public Health England (PHE)

MERS-CoV page
Key facts  (Oct 4, 2013)
Risk assessment (May 2, 2014)
Treatment of MERS-CoV: Decision support tool (Jul 14, 2014)
Infection control advice (Jun 28, 2013)
Primary care algorithm for MERS & avian flu (May 28, 2014)
Algorithm for management of possible cases (Jul 14, 2014)
Algorithm for management of close contacts (May 16, 2014)
Epidemiologic protocols (Nov 11, 2013)

Food and Drug Administration (FDA)

RT-PCR Assay fact sheet for health care professionals (Jun 12, 2014)
RT-PCR assay fact sheet for patients (Jun 12, 2014) 
Emergency use authorization (Jun 10, 2014)

World Organization for Animal Health (OIE)

Questions and answers  (Aug 2014)

Public Health Agency of Canada (PHAC)

Risk assessment (Oct 8, 2014)
Public health notice (Oct 1, 2014)
Travel health notice (Jul 24, 2014)
Infection prevention and control guidance (Oct 4, 2013)
Interim case definition (Sep 23, 2013)
Coronavirus in animals (May 28, 2013)
Case report form (Apr 22, 2013) 

Saudi Arabia Ministry of Health (MOH)

MERS-CoV Page 
Infection prevention and control precautions (May 15, 2013)
Frequently asked questions
Procedures for suspected or confirmed cases 
Media Statements  

Twitter 

CIDRAP (@CIDRAP)
Helen Branswell (@HelenBranswell)
Michael Coston (@Fla_Medic)
ECDC (@ECDC_EU)
Martin Enserink (@martinenserink)
FluTrackers (@FluTrackers)
Jason Gale (@jwgale)
Gregory Hartl (@HaertlG)
HealthMap.org (@healthmap)
Crawford Kilian (@crof)
Ian M Mackay, PhD (@MackayIM)
Maia Majumder, MPH (@maiamajumder)
NPR Global Health (@nprGlobalHealth)
Lisa Schnirring (@lisaschnirring)
Marc Sprenger (@ECDC_MSprenger)
World Health Organization (@WHO)

Recent Literature

Adney DR, van Doremalen N, Brown VR, et al. Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels. Emerg Infect Dis 2014 (published online Sep 24)

Al Hammadi ZM, Chu DK, Eltahir YM, et al. Asymptomatic MERS-CoV infection in humans possibly linked to infected camels imported from Oman to United Arab Emirates, May 2015. Emerg Infect Dis 2015 Dec;21(12)

Al-Abaidani IS, Al-Maani AS, Al-Kindi HS, et al. Overview of preparedness and response for Middle East respiratory syndrome coronavirus (MERS-CoV) in Oman. Int J Infect Dis 2014 (published online Oct 28)

Al-Tawfiq JA, Zumla A, Memish ZA. Travel implications of emerging coronaviruses: SARS and MERS-CoV. Travel Med Infect Dis 2014 Sep-Oct;12(5):422-8

Breakwell L, Pringle K, Chea N, et al. Lack of transmission among close contacts of patient with imported case of Middle East respiratory syndrome into the United States, 2014. Emerg Infect Dis 2015 (published online Apr 8)

Chan JFW, Yao Y, Yeung ML, et al. Treatment with lopinavir/ritonavir or interferon-beta-1b improves outcome of MERS-CoV infection in a non-human primate model of common marmoset.  J Infect Dis 2015 (published online Jul 21)

Chan SMS, Damdinjav B, Perera RAPM, et al. Absence of MERS-coronavirus in Bactrian camels, southern Mongolia, November 2014. (Letter) Emerg Infect Dis 2015 (published online Mar 4)

Chu J, Zhou J, Wong BH, et al. Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways. J Infect Dis 2015 (published online Jul 22)

Corti D, Zhao J, Pedotti M, et al. Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus. Proc Natl Acad Sci 2015 (published online Jul 27)

Cowling BJ, Park M, Fang V, et al. Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea, May to June 2015. Euro Surveill 2015 Jun 25;20(25):pii=21163

Fabgo SF, Skakni L, Chu DKW, et al. Molecular epidemiology of hospital outbreak of Middle East respiratory syndrome, Riyadh, Saudi Arabia, 2014. Emerg Infect Dis 2015 (published online Jul 20)

Feikin DR, Alraddadi B, Qutub M, et al. Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia, 2014. Emerg Infect Dis 2015 (published online Jul 24)

Gostin LO, Lucey D. Middle East respiratory syndrome: a global health challenge. (Commentary) JAMA 2015 (published online Jun 17)

Hall AJ, Tokars JI, Badreddine SA, et al. Health care worker contact with MERS patient, Saudi Arabia. Emerg Infect Dis 2014 (published online Nov 6)

Hemida MG, Al-Naeem A, Perera RAPM, et al. Lack of Middle East respiratory syndrome coronavirus transmission from infected camels. Emerg Infect Dis 2015 (published online Jan 12)

Khalafalla AI, Lu X, Al-Mubarak AIA, et al. MERS-CoV in upper respiratory tract and lungs of dromedary camels, Saudi Arabia, 2013-2014. Emerg Infect Dis 2015 (published online Apr 22)

Madani TA. Case definition and management of patients with MERS coronavirus in Saudi Arabia. Lancet Infect Dis 2014 Oct;14(10):911-3

Majumder MS, Kluberg SA, Mekaru SR, et al. Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea 2015. Emerg Infect Dis 2015 (published online Aug 19)

Maltezou HC, Tsiodras S. Middle East respiratory syndrome coronavirus: implications for health care facilities. Am J Infect Control 2014 Dec;42(12):1261-5

Memish ZA, Al-Tawfiq JA, Alhakeem RF, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): a cluster analysis with implications for global management of suspected cases. Travel Med Infect Dis 2015 (published online Jul 14)

Memish ZA, Alsahly A, al Masri M, et al. Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012. Influenza Other Respir Viruses 2014 (published online Dec 3)

Memish ZA, Assiri AM, Al-Tawfiq JA. Middle East respiratory syndrome coronavirus (MERS-CoV) viral shedding in the respiratory tract: an observational analysis with infection control implications. Int J Infect Dis 2014 (published online Oct 24)

Meyer B, Garcia-Bocanegra I, Wernery U, et al. Serologic assessment of possibility for MERS-CoV infection in equids. Emerg Infect Dis 2014 (published online Dec 10)

Mizumoto K, Saitoh M, Chowell G, et al. Estimating the risk of Middle East respiratory syndrome (MERS) death during the course of the outbreak in the Republic of Korea, 2015. Int J Infect Dis 2015 (published online Aug 11)

Muller MA, Meyer B, Corman VM, et al. Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study. Lancet Infect Dis 2015 (published online Apr 8)

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