MERS-CoV

Middle East respiratory syndrome coronavirus

Recent News

Apr 20, 2015

News Scan for Apr 20, 2015

Two more MERS cases
H5N1 in Egypt
Chikungunya uptick
New approach to sepsis
Fake-drug alert
Apr 17, 2015

News Scan for Apr 17, 2015

MERS in Saudi Arabia
California measles outbreak over
Apr 14, 2015

News Scan for Apr 14, 2015

New Saudi MERS case
Disclosure of trial results
Egg outbreak sentencing
CDC travel notices
Apr 13, 2015

News Scan for Apr 13, 2015

New strain in dog flu outbreak
Saudi MERS deaths, new health chief
More chikungunya
Drugs in food animals
Global Salmonella burden
Apr 09, 2015

Saudi serology study shows possible role for silent MERS infections

Also, the WHO in its most recent update notes frequent camel contact.

Apr 06, 2015

News Scan for Apr 06, 2015

Ebola in Sierra Leone
Two Saudi MERS cases
More chikungunya cases
Listeria-tied plant closure
Variant norovirus strain
Apr 02, 2015

News Scan for Apr 02, 2015

Rise of resistant shigellosis
New Saudi MERS case
Mar 31, 2015

News Scan for Mar 31, 2015

Chikungunya cases climb
MERS in Saudi Arabia
Oral HCV therapy
Endoscope contamination
Mar 30, 2015

Saudis report 5 MERS cases; WHO sees no change in pattern

The WHO reports 114 Saudi MERS cases in January & February, compared with 21 in that time last year.

Mar 26, 2015

Latest Saudi MERS update points to multiple exposures

A WHO update highlights a variety of possible exposures, including camels and sheep.

Resources & Literature

Resources

 

Jump to Recent Literature

 

Last updated Oct 8, 2014

Latest Cases & General Information

Frequently updated case list from FluTrackersTransmission electron micrograph of Middle East Respiratory Syndrome Coronavirus
Disease outbreak news from WHO
Maia Majumder, MPH, MERS resources on Tumblr
Virology Down Under MERS-CoV page
Naming of MERS-CoV from Science (May 6, 2013)
Genetic sequence of MERS-CoV from PHE

Health Agency Documents

World Health Organization (WHO)

MERS-CoV page 
List of latest case updates
Summary updates landing page
Latest risk assessment (Apr 24, 2014)
Frequently asked questions (May 9, 2014)
Interim Case Definitions (Jul 14, 2014)
Guidance on conducting case-control studies (Jul 15, 2014)
Interim surveillance recommendations (Jun 27, 2013)
Interim recommendations for laboratory testing (Sep 16, 2o13)
Seroepidemiological investigation of contacts (Nov 19, 2013)                                                                     Risk factors of infection among health care personnel (Jan 27, 2014)
Guidance for health care professionals (May 6, 2013)
Clinical management (Feb 11, 2013)
Home care for patients with MERS-CoV infection (Aug 8, 2013)
Travel recommendations (Jun 5, 2013)
Travel advice for pilgrims (Jun 3, 2014)
Naming of the novel coronavirus (May 28, 2013)

US Centers for Disease Control and Prevention (CDC)

MERS-CoV page
Press release on first US case
(May 2, 2014)
Press release on clearing of contacts of first 2 US cases (Jun 17, 2014)
Health Alert Network advisory (May 3, 2014)
Frequently asked questions
(Aug 4, 2014)
Case definitions (Jun 25, 2014)
Interim guidance for healthcare professionals (Jul 29, 2014)
Guidance for travelers (May 21, 2014)
Infection prevention and control guidelines (Jul 11, 2014)
Information and guidance for clinicians (Jun 18, 2013)
Guidance on air medical transport for MERS patients (Jul 3, 2014)

Interim guidance for airline crew
(Mar 10, 2014)
Guidelines for evaluation of MERS-CoV (Jun 7, 2013)                                                                                   Interim guidelines for collection, processing and transport of clinical specimens (Jun 7, 2013)          Interim guidance for preventing MERS-CoV from spreading in homes and communities (Jul 11, 2014)
Interim home care and isolation guidance for MERS-CoV (Jul 11, 2014)
Advanced molecular detection (Aug 25, 2014)
MERS-CoV Images                                                   

European Centre for Disease Prevention and Control (ECDC)

MERS-CoV page
Updated rapid risk assessment (Apr 25, 2014) 
Epidemiologic update
(May 16, 2014)

Public Health England (PHE)

MERS-CoV page
Key facts  (Oct 4, 2013)
Risk assessment (May 2, 2014)
Treatment of MERS-CoV: Decision support tool (Jul 14, 2014)
Infection control advice (Jun 28, 2013)
Primary care algorithm for MERS & avian flu (May 28, 2014)
Algorithm for management of possible cases (Jul 14, 2014)
Algorithm for management of close contacts (May 16, 2014)
Epidemiologic protocols (Nov 11, 2013)

Food and Drug Administration (FDA)

RT-PCR Assay fact sheet for health care professionals (Jun 12, 2014)
RT-PCR assay fact sheet for patients (Jun 12, 2014) 
Emergency use authorization (Jun 10, 2014)

World Organization for Animal Health (OIE)

Questions and answers  (Aug 2014)

Public Health Agency of Canada (PHAC)

Risk assessment (Oct 8, 2014)
Public health notice (Oct 1, 2014)
Travel health notice (Jul 24, 2014)
Infection prevention and control guidance (Oct 4, 2013)
Interim case definition (Sep 23, 2013)
Coronavirus in animals (May 28, 2013)
Case report form (Apr 22, 2013) 

Saudi Arabia Ministry of Health (MOH)

MERS-CoV Page 
Infection prevention and control precautions (May 15, 2013)
Frequently asked questions
Procedures for suspected or confirmed cases 
Media Statements  

Twitter 

CIDRAP (@CIDRAP)
Helen Branswell (@HelenBranswell)
Michael Coston (@Fla_Medic)
ECDC (@ECDC_EU)
Martin Enserink (@martinenserink)
FluTrackers (@FluTrackers)
Jason Gale (@jwgale)
Gregory Hartl (@HaertlG)
HealthMap.org (@healthmap)
Crawford Kilian (@crof)
Ian M Mackay, PhD (@MackayIM)
Maia Majumder, MPH (@maiamajumder)
NPR Global Health (@nprGlobalHealth)
Lisa Schnirring (@lisaschnirring)
Marc Sprenger (@ECDC_MSprenger)
World Health Organization (@WHO)

Recent Literature

Abroug F, Slim A, Ouanes-Besbes L, et al. Family cluster of Middle East respiratory syndrome coronavirus infections, Tunisia, 2013. Emerg Infect Dis 2014 (published online Jun 9)

Adney DR, van Doremalen N, Brown VR, et al. Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels. Emerg Infect Dis 2014 (published online Sep 24)

Al-Abaidani IS, Al-Maani AS, Al-Kindi HS, et al. Overview of preparedness and response for Middle East respiratory syndrome coronavirus (MERS-CoV) in Oman. Int J Infect Dis 2014 (published online Oct 28)

Al-Abdallat MM, Payne DC, Alqasrawi S, et al. Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description. Clin Infect Dis 2014 (published online May 14)

Al-Tawfiq JA, Zumla A, Memish ZA. Travel implications of emerging coronaviruses: SARS and MERS-CoV. Travel Med Infect Dis 2014 Sep-Oct;12(5):422-8

Azhar EI, El-Kafrawy SA, Farraj SA, et al. Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med 2014 (published online Jun 3)

Azhar EI, Hashem AM, El-Kafrawy SA, et al. Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient. MBio 2014 Jul 22;5(4):e01450-14

Breakwell L, Pringle K, Chea N, et al. Lack of transmission among close contacts of patient with imported case of Middle East respiratory syndrome into the United States, 2014. Emerg Infect Dis 2015 (published online Apr 8)

Briese T, Mishra N, Jain K, et al. Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia. MBio 2014;5(3):301146-14 (published online Apr 29)

CDC. First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities. MMWR 2014 May 14;63(early release):1-6

Chan RWY, Hemida MG, Kayali G, et al. Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study. Lancet Respir Med 2014 (published online Aug 29)

Chan SMS, Damdinjav B, Perera RAPM, et al. Absence of MERS-coronavirus in Bactrian camels, southern Mongolia, November 2014. (Letter) Emerg Infect Dis 2015 (published online Mar 4)

Corman VM, Ithete NL, Richards LR, et al. Rooting the phylogenetic tree of MERS-coronavirus by characterization of a conspecific virus from an African bat. J Virol 2014 (published online Jul 16)

Corman VM, Jores J, Meyer B, et al. Antibodies against MERS coronavirus in dromedary camels, Kenya, 1992-2013. Emerg Infect Dis 2014 Aug;20(8)

Drosten C, Meyer B, Muller MA, et al. Transmission of MERS-coronavirus in household contacts. N Engl J Med 2014 Aug 28;371(9):828-35

Falzarano D, de Wit E, Feldmann F, et al. Infection with MERS-CoV causes lethal pneumonia in the common marmoset. PLoS Pathog 2014 Aug 21;10(8):e1004250

Gardner LM, MacIntyre CR. Unanswered questions about the Middle East respiratory syndrome coronavirus (MERS-CoV). BMC Res Notes 2014 Jun 11;7:358

Hall AJ, Tokars JI, Badreddine SA, et al. Health care worker contact with MERS patient, Saudi Arabia. Emerg Infect Dis 2014 (published online Nov 6)

Hemida MG, Al-Naeem A, Perera RAPM, et al. Lack of Middle East respiratory syndrome coronavirus transmission from infected camels. Emerg Infect Dis 2015 (published online Jan 12)

Hemida MG, Perera RA, Al Jassim RA, et al. Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity. Euro Surveill 2014 Jun 12;19(23):pii=20828

Jiang L, Wang N, Zuo T, et al. Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein. Sci Transl Med 2014 (published online Apr 28)

Kapoor M, Pringle K, Kumar A, et al. Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) into the United States. Clin Infect Dis 2014 (published online Aug 6)

Leclercq I, Batejat C, Burguiere AM, et al. Heat inactivation of the Middle East respiratory syndrome coronavirus. Influenza Other Respir Viruses 2014 (published online Jul 29)

Madani TA. Case definition and management of patients with MERS coronavirus in Saudi Arabia. Lancet Infect Dis 2014 Oct;14(10):911-3

Maltezou HC, Tsiodras S. Middle East respiratory syndrome coronavirus: implications for health care facilities. Am J Infect Control 2014 Dec;42(12):1261-5

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