MERS-CoV

Middle East respiratory syndrome coronavirus

Recent News

Jun 28, 2016

News Scan for Jun 28, 2016

Saudi MERS cases
2009 H1N1 origins in Mexico
WHO health emergency head
Strategic National Stockpile report
Jun 27, 2016

News Scan for Jun 27, 2016

Saudi MERS cases
Signs of H7N7 in poultry workers
Diabetes and antibiotic prescribing
Jun 24, 2016

News Scan for Jun 24, 2016

White House Zika funding threat
Saudi MERS update
Flu vaccine developments
CDC lab incident disclosures
Measles susceptibility estimate
Jun 23, 2016

News Scan for Jun 23, 2016

Saudi MERS case
West Nile neurologic damage
Jun 22, 2016

News Scan for Jun 22, 2016

Saudi MERS update
Drug-resistant TB in kids
Speeding multi-site studies
Jun 21, 2016
Health worker donning gloves

WHO details Riyadh hospital MERS outbreak as new UAE, Saudi cases noted

The WHO details 20 cases involving the King Khalid University Hospital in Riyadh, and new cases are confirmed in both the UAE and in Jeddah.

Jun 20, 2016
Beds in hospital

Nine more infected in Riyadh MERS outbreak

Riyadh has 9 new cases, with at least 8 of them tied to a hospital cluster, and the WHO details 6 earlier cases.

Jun 17, 2016
Patient hospital bed

Saudi Arabia reports 11 MERS cases, 4 camel outbreaks

For a second day in a row, Saudi Arabia reported several cases from Riyadh, many asymptomatic and linked to healthcare setting exposure.

Jun 16, 2016
Healthcare contact

Saudi Arabia reports asymptomatic MERS cluster

Two of the patients are healthcare workers, and the other 3 were exposed via household contact.

Jun 15, 2016
MERS virus

MERS sickens 2 Saudis as study reveals new recombinant clade

The new MERS-CoV clade was implicated in a surge of 2015 illnesses.

Resources & Literature

Resources

 

Jump to Recent Literature

 

Last updated Oct 8, 2014

Latest Cases & General Information

Frequently updated case list from FluTrackersTransmission electron micrograph of Middle East Respiratory Syndrome Coronavirus
Disease outbreak news from WHO
Maia Majumder, MPH, MERS resources on Tumblr
Virology Down Under MERS-CoV page
Naming of MERS-CoV from Science (May 6, 2013)
Genetic sequence of MERS-CoV from PHE

Health Agency Documents

World Health Organization (WHO)

MERS-CoV page 
List of latest case updates
Summary updates landing page
Latest risk assessment (Apr 24, 2014)
Frequently asked questions (May 9, 2014)
Interim Case Definitions (Jul 14, 2014)
Guidance on conducting case-control studies (Jul 15, 2014)
Interim surveillance recommendations (Jun 27, 2013)
Interim recommendations for laboratory testing (Sep 16, 2o13)
Seroepidemiological investigation of contacts (Nov 19, 2013)                                                                     Risk factors of infection among health care personnel (Jan 27, 2014)
Guidance for health care professionals (May 6, 2013)
Clinical management (Feb 11, 2013)
Home care for patients with MERS-CoV infection (Aug 8, 2013)
Travel recommendations (Jun 5, 2013)
Travel advice for pilgrims (Jun 3, 2014)
Naming of the novel coronavirus (May 28, 2013)

US Centers for Disease Control and Prevention (CDC)

MERS-CoV page
Press release on first US case
(May 2, 2014)
Press release on clearing of contacts of first 2 US cases (Jun 17, 2014)
Health Alert Network advisory (May 3, 2014)
Frequently asked questions
(Aug 4, 2014)
Case definitions (Jun 25, 2014)
Interim guidance for healthcare professionals (Jul 29, 2014)
Guidance for travelers (May 21, 2014)
Infection prevention and control guidelines (Jul 11, 2014)
Information and guidance for clinicians (Jun 18, 2013)
Guidance on air medical transport for MERS patients (Jul 3, 2014)

Interim guidance for airline crew
(Mar 10, 2014)
Guidelines for evaluation of MERS-CoV (Jun 7, 2013)                                                                                   Interim guidelines for collection, processing and transport of clinical specimens (Jun 7, 2013)          Interim guidance for preventing MERS-CoV from spreading in homes and communities (Jul 11, 2014)
Interim home care and isolation guidance for MERS-CoV (Jul 11, 2014)
Advanced molecular detection (Aug 25, 2014)
MERS-CoV Images                                                   

European Centre for Disease Prevention and Control (ECDC)

MERS-CoV page
Updated rapid risk assessment (Apr 25, 2014) 
Epidemiologic update
(May 16, 2014)

Public Health England (PHE)

MERS-CoV page
Key facts  (Oct 4, 2013)
Risk assessment (May 2, 2014)
Treatment of MERS-CoV: Decision support tool (Jul 14, 2014)
Infection control advice (Jun 28, 2013)
Primary care algorithm for MERS & avian flu (May 28, 2014)
Algorithm for management of possible cases (Jul 14, 2014)
Algorithm for management of close contacts (May 16, 2014)
Epidemiologic protocols (Nov 11, 2013)

Food and Drug Administration (FDA)

RT-PCR Assay fact sheet for health care professionals (Jun 12, 2014)
RT-PCR assay fact sheet for patients (Jun 12, 2014) 
Emergency use authorization (Jun 10, 2014)

World Organization for Animal Health (OIE)

Questions and answers  (Aug 2014)

Public Health Agency of Canada (PHAC)

Risk assessment (Oct 8, 2014)
Public health notice (Oct 1, 2014)
Travel health notice (Jul 24, 2014)
Infection prevention and control guidance (Oct 4, 2013)
Interim case definition (Sep 23, 2013)
Coronavirus in animals (May 28, 2013)
Case report form (Apr 22, 2013) 

Saudi Arabia Ministry of Health (MOH)

MERS-CoV Page 
Infection prevention and control precautions (May 15, 2013)
Frequently asked questions
Procedures for suspected or confirmed cases 
Media Statements  

Twitter 

CIDRAP (@CIDRAP)
Helen Branswell (@HelenBranswell)
Michael Coston (@Fla_Medic)
ECDC (@ECDC_EU)
Martin Enserink (@martinenserink)
FluTrackers (@FluTrackers)
Jason Gale (@jwgale)
Gregory Hartl (@HaertlG)
HealthMap.org (@healthmap)
Crawford Kilian (@crof)
Ian M Mackay, PhD (@MackayIM)
Maia Majumder, MPH (@maiamajumder)
NPR Global Health (@nprGlobalHealth)
Lisa Schnirring (@lisaschnirring)
Marc Sprenger (@ECDC_MSprenger)
World Health Organization (@WHO)

Recent Literature

Adney DR, Bielefeldt-Ohmann H, Hartwig AE, et al. Infection, replication, and transmission of Middle East respiratory syndrome coronavirus in alpacas. Emerg Infect Dis 2016 Jun;22(6):1031-7

Al Hammadi ZM, Chu DK, Eltahir YM, et al. Asymptomatic MERS-CoV infection in humans possibly linked to infected camels imported from Oman to United Arab Emirates, May 2015. Emerg Infect Dis 2015 Dec;21(12)

Al Hosani FL, Pringle K, Al Mulla M, et al. Response to emergence of Middle East respiratory syndrome coronavirus, Abu Dhabi, United Arab

Alsahafi AJ, Cheng AC. The epidemiology of Middle East respiratory syndrome (MERS) coronavirus in the Kingdom of Saudi Arabia, 2012-2015. Int J Infect Dis 2016 (published online Feb 10)

Alshukairi AN, Khalid I, Ahmed WA, et al. Antibody response and disease severity in healthcare worker MERS survivors. Emerg Infect Dis 2016 (published online Apr 27)

Arwady MA, Alraddadi B, Basler C, et al. Middle East respiratory syndrome coronavirus transmission in extended family, Saudi Arabia, 2014. Emerg Infect Dis 2016 (published online May 18)

Assiri A, Abedi GR, Saeed AAB, et al. Multifacility outbreak of Middle East respiratory syndrome in Taif, Saudi Arabia. Emerg Infect Dis 2015 (published online Nov 2)

Assiri AM, Midgley CM, Abedi GR, et al. Epidemiology of a novel recombinant MERS-CoV in humans in Saudi Arabia. J Infect Dis 2016 (published online Jun 14)

Atabani, SF, Wilson S, Overton-Lewis C, et al. Active screening and surveillance in the United Kingdom for Middle East respiratory syndrome coronavirus in returning travelers and pilgrims from the Middle East — a prospective descriptive study for the period 2013-2015. Int J Infect Dis 2016 (published online Apr 23)

Badawi A, Ryoo SG. Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis. Int J Infect Dis 2016 (published online Jun 21)

Balkhy HH, Alenazi TH, Alshamrani MM, et al. Nosocomial outbreak of Middle East respiratory syndrome in a large tertiary care hospital — Riyadh, Saudi Arabia, 2015. (Notes from the field) MMWR 2016 Feb 19;65(6):163-4

Butt TS, Koutlakis-Barron I, AlJumaah S, et al. Infection control and prevention practices implemented to reduce transmission risk of Middle East respiratory syndrome-coronavirus in a tertiary care institution in Saudi Arabia. Am J Infect Control 2016 (published online Feb 25)

Chan JFW, Yao Y, Yeung ML, et al. Treatment with lopinavir/ritonavir or interferon-beta-1b improves outcome of MERS-CoV infection in a non-human primate model of common marmoset.  J Infect Dis 2015 (published online Jul 21)

Chowell G, Abdirizak F, Lee S, et al. Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study. BMC Medicine 2015 Sep 3;13:210

Chu DK, Oladipo JO, Perera RA, et al. Middle East respiratory syndrome coronavirus (MERS-COV) in dromedary camels in Nigeria, 2015. Euro Surveill 2015 Dec 10;20(49):pii=30086

Chu J, Zhou J, Wong BH, et al. Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways. J Infect Dis 2015 (published online Jul 22)

Corman VM, Albarrak AM, Omrani AS, et al. Viral shedding and antibody response in 37 patients with MERS-coronavirus infection. Clin Infect Dis 2015 (published online Nov 12)

Corti D, Zhao J, Pedotti M, et al. Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus. Proc Natl Acad Sci 2015 (published online Jul 27)

Crameri G, Durr PA, Klein R, et al. Experimental infection and response to rechallenge of alpacas with Middle East respiratory syndrome coronavirus. Emerg Infect Dis 2016 (published online Mar 3)

Deem SL, Fevre EM, Kinnaird M, et al. Serological evidence of MERS-CoV antibodies in dromedary camels (Camelus dromedaries) in Laikipia County, Kenya. PLoS One 2015 Oct 16;10(10):e0140125

Fabgo SF, Skakni L, Chu DKW, et al. Molecular epidemiology of hospital outbreak of Middle East respiratory syndrome, Riyadh, Saudi Arabia, 2014. Emerg Infect Dis 2015 (published online Jul 20)

Feikin DR, Alraddadi B, Qutub M, et al. Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia, 2014. Emerg Infect Dis 2015 (published online Jul 24)

Gutierrez C, Tejedor-Junco MT, Gonzalez M, et al. Presence of antibodies but no evidence for circulation of MERS-CoV in dromedaries on the Canary Islands, 2015. Euro Surveill 2015 Sep 17;20(37):pii=30019

Haagmans BL, van den Brand JMA, Raj VS, et al. An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels. Science 2015 (published online Dec 17)

Hastings DL, Tokars JI, Abdel Aziz IZAM, et al. Outbreak of Middle East respiratory syndrome at tertiary care hospital, Jeddah, Saudi Arabia, 2014. Emerg Infect Dis 2016 (published online Apr 13)

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