Middle East respiratory syndrome coronavirus

Recent News

Nov 25, 2015

News Scan for Nov 25, 2015

South Korea MERS death
Chikungunya vaccine trial
Nov 13, 2015
Doctors in hospital

MERS update sheds light on Saudi hospital cases

WHO provides new details on 7 recent Saudi MERS cases, 6 of which had healthcare links.

Nov 13, 2015

Study notes MERS, SARS virus shedding similarities

Scientists find that the timing and intensity of MERS virus shedding is similar to SARS.

Nov 12, 2015
Riyadh map

Saudi Arabia notes MERS case, upcoming meeting

The lastest patient, a foreign man in Riyadh, contracted the disease in a healthcare setting.

Nov 10, 2015

Coronavirus Scan for Nov 10, 2015

Saudi MERS research project
SARS-like virus's human adaptability
Copper against coronavirus
Nov 03, 2015
Taif city, Saudi Arabia

New Saudi MERS case as year-old Taif cluster detailed

The new patient is in Riyadh, and a study highlights a 38-patient cluster that saw a 55% fatality rate.

Nov 02, 2015

News Scan for Nov 02, 2015

New Saudi MERS case
Chipotle E coli outbreak
Cholera in Iraq
Oct 29, 2015
Riyadh apartments

Saudi Arabia notes new MERS case; WHO details 12

The latest patient is a foreign health worker, the eighth case in a Hofuf hospital cluster.

Oct 28, 2015

News Scan for Oct 28, 2015

MERS in Saudi Arabia
High global herpes rate
MDR-TB outcomes
Oct 27, 2015
Saudi Arabia map

Four new Saudi MERS cases include 2 in Hofuf cluster

Two cases are part of what appears to be a growing hospital outbreak in Hofuf, and the other 2 are in Riyadh.

Resources & Literature



Jump to Recent Literature


Last updated Oct 8, 2014

Latest Cases & General Information

Frequently updated case list from FluTrackersTransmission electron micrograph of Middle East Respiratory Syndrome Coronavirus
Disease outbreak news from WHO
Maia Majumder, MPH, MERS resources on Tumblr
Virology Down Under MERS-CoV page
Naming of MERS-CoV from Science (May 6, 2013)
Genetic sequence of MERS-CoV from PHE

Health Agency Documents

World Health Organization (WHO)

MERS-CoV page 
List of latest case updates
Summary updates landing page
Latest risk assessment (Apr 24, 2014)
Frequently asked questions (May 9, 2014)
Interim Case Definitions (Jul 14, 2014)
Guidance on conducting case-control studies (Jul 15, 2014)
Interim surveillance recommendations (Jun 27, 2013)
Interim recommendations for laboratory testing (Sep 16, 2o13)
Seroepidemiological investigation of contacts (Nov 19, 2013)                                                                     Risk factors of infection among health care personnel (Jan 27, 2014)
Guidance for health care professionals (May 6, 2013)
Clinical management (Feb 11, 2013)
Home care for patients with MERS-CoV infection (Aug 8, 2013)
Travel recommendations (Jun 5, 2013)
Travel advice for pilgrims (Jun 3, 2014)
Naming of the novel coronavirus (May 28, 2013)

US Centers for Disease Control and Prevention (CDC)

MERS-CoV page
Press release on first US case
(May 2, 2014)
Press release on clearing of contacts of first 2 US cases (Jun 17, 2014)
Health Alert Network advisory (May 3, 2014)
Frequently asked questions
(Aug 4, 2014)
Case definitions (Jun 25, 2014)
Interim guidance for healthcare professionals (Jul 29, 2014)
Guidance for travelers (May 21, 2014)
Infection prevention and control guidelines (Jul 11, 2014)
Information and guidance for clinicians (Jun 18, 2013)
Guidance on air medical transport for MERS patients (Jul 3, 2014)

Interim guidance for airline crew
(Mar 10, 2014)
Guidelines for evaluation of MERS-CoV (Jun 7, 2013)                                                                                   Interim guidelines for collection, processing and transport of clinical specimens (Jun 7, 2013)          Interim guidance for preventing MERS-CoV from spreading in homes and communities (Jul 11, 2014)
Interim home care and isolation guidance for MERS-CoV (Jul 11, 2014)
Advanced molecular detection (Aug 25, 2014)
MERS-CoV Images                                                   

European Centre for Disease Prevention and Control (ECDC)

MERS-CoV page
Updated rapid risk assessment (Apr 25, 2014) 
Epidemiologic update
(May 16, 2014)

Public Health England (PHE)

MERS-CoV page
Key facts  (Oct 4, 2013)
Risk assessment (May 2, 2014)
Treatment of MERS-CoV: Decision support tool (Jul 14, 2014)
Infection control advice (Jun 28, 2013)
Primary care algorithm for MERS & avian flu (May 28, 2014)
Algorithm for management of possible cases (Jul 14, 2014)
Algorithm for management of close contacts (May 16, 2014)
Epidemiologic protocols (Nov 11, 2013)

Food and Drug Administration (FDA)

RT-PCR Assay fact sheet for health care professionals (Jun 12, 2014)
RT-PCR assay fact sheet for patients (Jun 12, 2014) 
Emergency use authorization (Jun 10, 2014)

World Organization for Animal Health (OIE)

Questions and answers  (Aug 2014)

Public Health Agency of Canada (PHAC)

Risk assessment (Oct 8, 2014)
Public health notice (Oct 1, 2014)
Travel health notice (Jul 24, 2014)
Infection prevention and control guidance (Oct 4, 2013)
Interim case definition (Sep 23, 2013)
Coronavirus in animals (May 28, 2013)
Case report form (Apr 22, 2013) 

Saudi Arabia Ministry of Health (MOH)

MERS-CoV Page 
Infection prevention and control precautions (May 15, 2013)
Frequently asked questions
Procedures for suspected or confirmed cases 
Media Statements  


Helen Branswell (@HelenBranswell)
Michael Coston (@Fla_Medic)
Martin Enserink (@martinenserink)
FluTrackers (@FluTrackers)
Jason Gale (@jwgale)
Gregory Hartl (@HaertlG) (@healthmap)
Crawford Kilian (@crof)
Ian M Mackay, PhD (@MackayIM)
Maia Majumder, MPH (@maiamajumder)
NPR Global Health (@nprGlobalHealth)
Lisa Schnirring (@lisaschnirring)
Marc Sprenger (@ECDC_MSprenger)
World Health Organization (@WHO)

Recent Literature

Al Hammadi ZM, Chu DK, Eltahir YM, et al. Asymptomatic MERS-CoV infection in humans possibly linked to infected camels imported from Oman to United Arab Emirates, May 2015. Emerg Infect Dis 2015 Dec;21(12)

Assiri A, Abedi GR, Saeed AAB, et al. Multifacility outbreak of Middle East respiratory syndrome in Taif, Saudi Arabia. Emerg Infect Dis 2015 (published online Nov 2)

Breakwell L, Pringle K, Chea N, et al. Lack of transmission among close contacts of patient with imported case of Middle East respiratory syndrome into the United States, 2014. Emerg Infect Dis 2015 (published online Apr 8)

Chan JFW, Yao Y, Yeung ML, et al. Treatment with lopinavir/ritonavir or interferon-beta-1b improves outcome of MERS-CoV infection in a non-human primate model of common marmoset.  J Infect Dis 2015 (published online Jul 21)

Chan SMS, Damdinjav B, Perera RAPM, et al. Absence of MERS-coronavirus in Bactrian camels, southern Mongolia, November 2014. (Letter) Emerg Infect Dis 2015 (published online Mar 4)

Chowell G, Abdirizak F, Lee S, et al. Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study. BMC Medicine 2015 Sep 3;13:210

Chu J, Zhou J, Wong BH, et al. Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways. J Infect Dis 2015 (published online Jul 22)

Corman VM, Albarrak AM, Omrani AS, et al. Viral shedding and antibody response in 37 patients with MERS-coronavirus infection. Clin Infect Dis 2015 (published online Nov 12)

Corti D, Zhao J, Pedotti M, et al. Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus. Proc Natl Acad Sci 2015 (published online Jul 27)

Cowling BJ, Park M, Fang V, et al. Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea, May to June 2015. Euro Surveill 2015 Jun 25;20(25):pii=21163

Deem SL, Fevre EM, Kinnaird M, et al. Serological evidence of MERS-CoV antibodies in dromedary camels (Camelus dromedaries) in Laikipia County, Kenya. PLoS One 2015 Oct 16;10(10):e0140125

Fabgo SF, Skakni L, Chu DKW, et al. Molecular epidemiology of hospital outbreak of Middle East respiratory syndrome, Riyadh, Saudi Arabia, 2014. Emerg Infect Dis 2015 (published online Jul 20)

Feikin DR, Alraddadi B, Qutub M, et al. Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia, 2014. Emerg Infect Dis 2015 (published online Jul 24)

Gostin LO, Lucey D. Middle East respiratory syndrome: a global health challenge. (Commentary) JAMA 2015 (published online Jun 17)

Gutierrez C, Tejedor-Junco MT, Gonzalez M, et al. Presence of antibodies but no evidence for circulation of MERS-CoV in dromedaries on the Canary Islands, 2015. Euro Surveill 2015 Sep 17;20(37):pii=30019

Hemida MG, Al-Naeem A, Perera RAPM, et al. Lack of Middle East respiratory syndrome coronavirus transmission from infected camels. Emerg Infect Dis 2015 (published online Jan 12)

Johnson RF, Via LE, Kumar MR, et al. Intratracheal exposure to common marmosets to MERS-CoV Jordan-n3/3012 or MERS-CoV EMC/2012 isolates does not result in lethal disease. Virology 2015 (published online Sep 3)

Khalafalla AI, Lu X, Al-Mubarak AIA, et al. MERS-CoV in upper respiratory tract and lungs of dromedary camels, Saudi Arabia, 2013-2014. Emerg Infect Dis 2015 (published online Apr 22)

Lee SS, Wong NS. Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea. Int J Infect Dis 2015 Sep;38(suppl C): 65-7

Li K, Wohlford-Lenane C, Perlman S, et al. Middle East respiratory syndrome coronavirus cause multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4. J Infect Dis 2015 (published online Oct 20)

Majumder MS, Kluberg SA, Mekaru SR, et al. Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea 2015. Emerg Infect Dis 2015 (published online Aug 19)

Maltezou HC, Tsiodras S. Middle East respiratory syndrome coronavirus: implications for health care facilities. Am J Infect Control 2014 Dec;42(12):1261-5

Memish ZA, Al-Tawfiq JA, Alhakeem RF, et al. Middle East respiratory syndrome coronavirus (MERS-CoV): a cluster analysis with implications for global management of suspected cases. Travel Med Infect Dis 2015 (published online Jul 14)

Memish ZA, Alsahly A, al Masri M, et al. Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012. Influenza Other Respir Viruses 2014 (published online Dec 3)

Meyer B, Garcia-Bocanegra I, Wernery U, et al. Serologic assessment of possibility for MERS-CoV infection in equids. Emerg Infect Dis 2014 (published online Dec 10)

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