(CIDRAP News) – Health officials have suspected a drop-off in protection from the childhood acellular pertussis vaccine as one factor in surging disease levels, and new data today on Minnesota and Oregon kids provide the strongest evidence yet that immunity wanes before they get a booster dose at age 11 or 12.
(CIDRAP News) – Researchers in other countries have found evidence that circulating strains of Bordetella pertussis have adapted to the acellular vaccine, and researchers today reported similar findings for the first time in US kids, based on genetic analysis of isolates from hospitalized children.
Resources & Literature
Recent Literature
Amirthalingam G, Gupta S, Campbell H. Pertussis immunisation and control in England and Wales, 1957 to 2012: a historical review. Euro Surveill 2013 Sep 19;18(38):pii=20587
Andre P, Johnson DR, Greenberg DP, et al. Reduced risk of pertussis in whole-cell compared to acellular vaccine recipients is not supported when data are stratified by age. Clin Infect Dis 2013 (published online Aug 15)
Baxter R, Bartlett J, Rowhani-Rahbar A, et al. Effectiveness of pertussis vaccines for adolescents and adults: case-control study. BMJ 2013 Jul 17;347:f4249
CDC. Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) in pregnant women--Advisory Committee on Immunization Practices (ACIP), 2012. MMWR 2013 Feb 22;62(07):131-5
Ercan TE, Sonmez C, Vural M, et al. Seroprevalance of pertussis antibodies in maternal and cord blood of preterm and term infants. Vaccine 2013 Aug 28;31(38):4172-6
King AJ, van der Lee S, Mohangoo A, et al. Genome-wide gene expression analysis of Bordetella pertussis isolates associated with a resurgence in pertussis: elucidation of factors involved in the increased fitness of epidemic strains. PLoS One 2013 Jun 11;8(6):e66150
Lugner AK, van der Maas N, van Boven M, et al. Cost-effectveness of targeted vaccination to protect new-borns against pertussis: comparing neonatal, maternal, and cocooning vaccination strategies. Vaccine 2013 (published online Sep 27)
Terranella A, Asay GR, Messonnier ML, et al. Pregnancy dose tdap and postpartum cocooning to prevent infant pertussis: a decision analysis. Pediatrics 2013 Jun;131(6):e1748-56
Wiley KE, Massey PD, Cooper Robbins SC, et al. Pregnant women's intention to take up a post-partum pertussis vaccine, and their willingness to take up the vaccine while pregnant: A cross sectional survey. Vaccine 2013 Aug 20;31(37):3972-8
Yeh S, Mink C, Kim M, et al. Effectiveness of hospital-based postpartum procedures of pertussis vaccination among postpartum women. Am J Obstet Gynecol 2013 (published online Oct 2)
