University of Minnesota. Driven to Discover.
Severe acute respiratory syndrome
The virus killed nearly 25,000 piglets at 4 farms in Guangdong province in 2016 and 2017.
New viruses had all the building blocks of the human virus, and lab exeriments found that some are equipped with the same capacity to enter human cells.
Genetic analysis of a virus from Uganda revealed that it is 87% identical to MERS-CoV.
The panel's concern was fueled by the threat of an airborne virus spread more easily than Ebola.
Ar Gouilh M, Puechmaille SJ, Diancourt L, et al. SARS-CoV related Betacoronavirus and diverse Alphacoronavirus members found in western old-world. Virology 2018 (published online Feb 23)
Hu B, Zeng LP, Yang XL, et al. Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus. PLoS Pathog 2017 Nov 30;13(11):e1006698
Sheahan TP, Sims AC, Graham RL, et al. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med 2017 (published online Jun 28)
Xiao S, Li Y, Wong TW, et al. Role of fomites in SARS transmission during the largest hospital outbreak in Hong Kong. PLoS One 2017 Jul 20;12(7):e0181558
Zhou P, Fan H, Lan T, et al. Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin. (Letter) Nature 2018 (published online Apr 4)
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CIDRAP - Center for Infectious Disease Research and PolicyAcademic Health Center, University of Minnesota, Minneapolis, MN
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