Stewardship / Resistance Scan for Nov 07, 2018

Economic report on AMR interventions
;
Pioneering efforts against resistance
;
Poor public antibiotic knowledge

OECD: Interventions to reduce resistant bacteria could save lives, money

A report today from the Organization for Economic Co-operation and Development (OECD) suggests that investment in a package of measures to reduce antimicrobial resistance (AMR) could avert thousands of deaths each year and save money in the long run.

According to the OECD analysis, the proportion of infections caused by antibiotic-resistant bacteria could increase from 17% in 2015 to 18% in 2030 across the 33 OECD countries, with resistance to second- and third-line antibiotics expected to be 70% higher by 2030. In countries outside the OECD, resistance rates are higher and projected to grow even faster. If no effective action is taken, the report warns, an estimated 2.4 million people in Europe, North America, and Australia could die between 2015 and 2050, and OECD countries could spend up to $3.5 billion a year on AMR-related complications.

The report suggests, however, that governments could counter the problem with a combination of five affordable public health interventions: (1) improved environmental hygiene in healthcare facilities, including better hand hygiene; (2) stewardship programs to promote more prudent use of antibiotics; (3) use of rapid diagnostic tests to differentiate between bacterial and viral infections; (4) delayed antibiotic prescribing; (5) and public awareness campaigns.

"All the assessed interventions are 'best buys' to tackle AMR in the assessed countries given their high impact on population health, affordability to implement, and excellent cost-effectiveness ratio," write the authors of the report. "Savings from delayed prescriptions, improved hand hygiene, and, in most cases, from stewardship programmes exceed the cost of implementation."

The OECD analyzed three different packages of interventions and estimated that a mixed intervention package that includes stewardship programs, use of rapid diagnostic tests, mass media campaigns, and enhanced hospital hygiene could avert up to 47,000 deaths and save around $3 per person a year in OECD countries.
Nov 7 OECD report

 

'Pioneering' AMR initiatives to be highlighted at upcoming conference

The Wellcome Trust announced today that it has chosen two projects that are taking "pioneering" action to combat AMR to present their work at the upcoming Call to Action conference in Ghana on Nov 18-19.

One of the projects is based in Bangladesh and involves a community dialogues approach to helping prevent the growth of AMR. Led by the University of Leeds in collaboration with the Malaria Consortium and ARK Foundation, the project trains volunteers to facilitate dialogues with community members about the rational use of antibiotics. From April 2018 through July 2018, volunteers hosted more than 200 meetings in the Comilla district of Bangladesh.

The other project is Superheroes Against Superbugs, a program that teaches schoolchildren in India about bacteria, antibiotics, and resistance and encourages them to create a dialogue about AMR through comic books, short animated films, and other creative concepts.

The two initiatives will be highlighted on day one of the Call to Action conference, which will bring together health officials from national governments and agencies and representatives from the private and philanthropic sectors to address the most critical gaps in tackling the development and spread of drug-resistant infections. The conference is being co-hosted by Wellcome Trust, the United Nations Foundation, and the governments of Ghana and Thailand.
Nov 7 Wellcome Trust news release

 

Nationwide survey in Japan finds deep misconceptions about antibiotics

A nationwide survey in Japan has found that misconceptions about antimicrobials and antimicrobial resistance (AMR) abound, and many have taken antimicrobials inappropriately, with almost half having obtained antibiotics for the common cold, according to a study in PLOS One.

Researchers conducted the online survey in March 2017 and collected data from 3,390 participants. Questions focused on antibiotic use, knowledge about the drugs and AMR, sources of antibiotic information, and behavior and perception of antibiotics during visits with healthcare providers.

Almost half (46.2%) of the respondents had taken antibiotics, 45.5% of them for the common cold, which doesn't require antibiotics. The study also found that 11.7% of participants stored antibiotics at home and 23.6% said they had stopped or adjusted antibiotic doses by themselves; 1.9% of respondents had taken leftover antibiotics.

Regarding antibiotic and AMR knowledge, only 21.9% knew that antibiotics could not kill viruses, which compares with 43% in Europe, the authors said. In addition, only 24.6% of Japanese knew antibiotics were not effective against colds and influenza. Although 67.5% of participants knew that antibiotics would not work in the future unless used properly, only about 20% of them knew what kind of diseases or pathogens they target. Only 7.1% answered all four questions about antibiotics correctly.

During medical visits, 10.2% asked for antibiotic prescriptions from their physicians, and 30.2% believed that physicians who prescribed the drugs for the common cold were good.

The authors conclude, "Although information about antibiotics and AMR has not been adequately shared to the Japanese public, the majority of them who did have the correct information reported their wish for changes to improve the behaviour of people with regards to use of antibiotics."
Nov 5 PLOS One study

Newsletter Sign-up

Get CIDRAP news and other free newsletters.

Sign up now»

OUR UNDERWRITERS

Unrestricted financial support provided by

Bentson Foundation 3MAccelerate DiagnosticsGilead 
Grant support for ASP provided by

  Become an underwriter»