Antimicrobial Stewardship: Selected Reads

In this weekly analysis of the literature on antimicrobial resistance (AMR) and stewardship, CIDRAP-ASP’s Francesca Chiara, PhD, MPH, MSc, Jamie Umber, DVM, MPH, and Natalie Vestin, MPH, will highlight an article that brings new and relevant information and perspective to global AMR work.

Recent posts

Contribution of wastewater to antimicrobial resistance: a review article

This review evaluates factors along the wastewater pathway that may contribute to the emergence or worsening of antibiotic-resistant bacteria, along with challenges and opportunities related to the effectiveness of wastewater treatment strategies and regulations on AMR in the environment.

Natalie Vestin, MPH

Vaccination is an integral strategy to combat antimicrobial resistance

This article on the implications of vaccines on AMR delves into who is most likely to benefit from bacterial vaccines, the challenges that AMR and antigen identification pose to vaccine development, and current and investigational vaccine development platforms.

Natalie Vestin, MPH

Economic and cost-effectiveness aspects of vaccines in combating antibiotic resistance

This literature review assessed two studies that directly estimated AMR costs averted due to pneumococcal vaccine use in China and Ethiopia, as well as a series of cost-effectiveness studies for immunization in the context of AMR, for vaccines in development and under license as of June 1, 2022.

Natalie Vestin, MPH

Selected Reads Team

Francesca Chiara

Francesca Chiara, PhD, MPH, MRes

Director, Antimicrobial Stewardship
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Jamie Umber, DVM, MPH

Jamie Umber, DVM, MPH

Senior Veterinary Epidemiologist, Co-Director, CWD
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Natalie Vestin

Natalie Vestin, MPH

Research Associate
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Past posts

Past posts

Information delay of significant bloodstream isolates and patient mortality: a retrospective analysis of 6,225 adult patients with bloodstream infection

This study evaluated the association between mortality and delays in reporting blood culture positivity and bacterial species identification in 6,225 patients with bacteremia treated at a Barcelona hospital from January 2013 to December 2019.

Natalie Vestin, MPH

The incidence of histoplasmosis and cryptococcal antigenemia among patients attending a large HIV clinic in Trinidad

This study evaluated the use of antigen assays to screen for Histoplasma capsulatum and Cryptococcus neoformans in 280 people living with HIV who had CD4+ counts of less than 350 cells per cubic millimeter (mm3) from November 2021 to June 2022 at an HIV clinic in Trinidad.

Natalie Vestin, MPH

New perspectives on primary prophylaxis of invasive fungal infection in children undergoing hematopoietic stem cell transplantation: a 10-year retrospective cohort study

This retrospective study evaluates the incidence of invasive fungal infections (IFIs) in 308 children who received an allogenic hematopoietic stem cell transplant in a French hospital that relies on environmental hygiene and air filtration, rather than systematic primary antifungal prophylaxis, from 2010 to 2020.

Natalie Vestin, MPH

Food and Drug Administration public workshop summary—development considerations of antifungal drugs to address unmet medical need

This article summaries discussions involving academia, the pharmaceutical industry, patient groups, and government agencies held during a 2020 US Food and Drug Administration (FDA) workshop to improve the regulatory and clinical trial infrastructure necessary to develop antifungals for invasive fungal infections.

Natalie Vestin, MPH

Approach to the diagnosis of invasive fungal infections of the respiratory tract in the immunocompromised host

This review examines the intersecting patient characteristics, clinical and imaging signs and pathways, and diagnostic tests available and in development to aid in rapid assessment of invasive fungal respiratory infections in immunocompromised people.

Natalie Vestin, MPH

Reservoirs of antimicrobial resistance in the context of One Health

This review highlights current insights into the emergence and spread of antimicrobial resistance (AMR) from a One Health perspective. A major challenge for One Health studies is attributing the directionality of transmission of antimicrobial resistance genes (ARGs) between different metagenomes.

 

 

Jamie Umber, DVM, MPH

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