True stories from scientists and patients around the globe
Over the past decade, several strains (types) of Salmonella typhi have become resistant to multiple antibiotics. Resistant strains have been identified across the globe. However, the 2018 launch of a vaccine has slowed infections. It is estimated that TCV introduction with a catch-up campaign will avert 42.5 million cases and 506,000 deaths caused by fluoroquinolone-resistant typhoid fever, and 21.2 million cases and 342,000 deaths from multidrug-resistant typhoid fever over 10 years following introduction. This episode will cover the impact of vaccinations and the challenges to deploy effective programs.
Guests:
For more information on the impact of typhoid conjugate vaccines and AMR, check out CIDRAP-ASP's report, A Vaccine Is a Bridge: The New Era of Typhoid Prevention.
Episode Eleven: Fighting for the Future: Neonatal Sepsis
Despite great improvements in mortality for children under 5, sepsis remains a leading cause of death in young children. The highest incidence and mortality were seen in newborns, with the biggest impact seen in low- and middle-income countries in sub-Saharan Africa and Asia. This episode will highlight how the availability of guidelines, diagnostics, and therapeutics can make a difference in the smallest of patients. Content warning: this episode contains discussions of infant loss.
Materials Mentioned in this Episode
Around the world, the multidrug resistant and pan-resistantfungus Candida auris has caused outbreaks in healthcare systems. While it is now highlighted by CDC as an urgent threat, only six years ago there were no reports of resistant C. auris strains that were able to spread easily between patients. These infections are challenging to treat a with 5% — 10% of colonized patients going on to develop invasive infections. This episode will cover how these outbreaks have impacted patients, healthcare systems, and continued efforts to better understand and slow the impact of these infections.
Defined as an “urgent” AMR threat by the US CDC, resistant Acinetobacter baumanii cause deadly infections and are difficult to remove from the environment. Acinetobacter is resistant to many antibiotics and is a frequent cause of hospital acquired infections. In the 2022 Lancet publication on drug-resistant infections (GRAM report), it was identified as the leading pathogen causing mortality in Southeast Asia. This episode will cover how infections caused by resistant Acinetobacter impact patients and on how new treatments are making an impact.
Join us for a sneak peak of Season 3 of Superbugs and You by listening to a portion of our interview with Dr. Tom Chiller, Chief of the Mycotic Diseases Branch at the Centers for Disease Control and Prevention, discussing Candida auris.
Neisseria gonorrhoeae is the second most common bacterial sexually transmitted infection in the world, and it has become a superbug. It has developed resistance to every antibiotic currently approved for treatment, and multidrug-resistant strains have been identified globally. Hear from clinicians advocating for their patients, a global leader, and a leading expert in drug development on actions needed to combat resistant gonorrhea.
In this episode, we will explore the ways that antimicrobial resistance impacts treatment for some of the most vulnerable patients, such as those undergoing cancer treatment or receiving bone marrow transplants. A recent survey of oncologists showed that 95% of them worry about the impact of superbugs on the future of cancer treatments, and one in five patients receiving chemotherapy will have a bacterial infection. In this episode, you will hear directly from a patient who had a bacterial infection while fighting cancer, from front-line clinicians, and from a researcher driving policy at a national level.
Clostridioides difficile (also known as C. diff or CDI) can cause deadly diarrhea. It is the most common healthcare-associated infection in the United States and rates of infections are rising globally. In this episode, we hear how a young Mom was impacted by the disease, how leading healthcare organizations are driving best practice guidelines, and how the US CDC is tracking this superbug.
Methicillin-resistant S. aureus (MRSA) is found in the community and in healthcare systems. According to the WHO, hospitalized patients with MRSA infections are 64% more likely to die than people with drug-sensitive infections. It can be difficult to treat. In this episode, hear from a patient who battled an infection for years, a infectious disease clinician who shares his daily challenges, and a researcher who using an unique approach to find the next antibiotic.
In this final episode of Season 1, we discuss how the COVID-19 pandemic has impacted strategies to address antimicrobial resistance. Our guests will describe the patient experience of surviving COVID, the role of antimicrobial stewardship in managing COVID patients, and how the COVID-19 pandemic potentiates AMR and emerging approaches to the surveillance, treatment and prevention of AMR.
In this episode, we discuss the global issue of multidrug-resistant tuberculosis or TB. Our guests in this episode will describe living with TB, and the experience of managing these difficult-to-treat infections. They will also examine the role that social structures, local governance, accessible and affordable treatments, and patient advocacy play in tuberculosis transmission and management.
