Report: Narrowing the Focus: Optimizing Antibiotic Spectrum to Improve Patient Outcomes

Unnecessary broad-spectrum antibiotic (BSA) use is a persistent challenge. However, there are numerous opportunities to enhance prescribing to minimize harm, improve patient outcomes, and combat antimicrobial resistance (AMR). This evidence review highlights the risks associated with BSAs, including microbiome disruption, organ toxicity, increased healthcare costs, longer hospital stays, and higher mortality rates. The summary emphasizes the importance of informed prescribing decisions based on diagnostic testing, patient risk factors, and local epidemiology.

Key insights from this evidence review highlight the importance of diagnostic testing, patient risk assessment, and stewardship interventions across clinical settings. The review also examines specific challenges in sepsis management and pediatric outpatient care, emphasizing the role of rapid diagnostics, clinician education, and public awareness in reducing inappropriate prescribing.

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