Avian Flu Scan for Jul 25, 2016

News brief

H5N1 sickens 3 more in Egypt

Egypt recently reported three new H5N1 avian flu cases, all in people who had been exposed to poultry or their environments, according to a monthly update from the World Health Organization (WHO) on animal-to-human flu transmission events for the middle of June through the middle of July.

One of the patients is a 2-year-old boy from Cairo who got sick on May 30 and whose H5N1 illness was detected as part of flulike illness surveillance. He was hospitalized, treated with antivirals for pneumonia, and recovered. Before he became ill the boy had visited a family member who raised birds.

The other two are a 30-year-old woman from Menia governorate whose symptoms began on Jun 11 and an 8-year-old girl from Cairo governorate who got sick on Jun 18. Both had been exposed to poultry or their environments, were hospitalized with pneumonia, and recovered after antiviral treatment.

The WHO said no other cases were detected in any of the patients' contact and that H5N1 is endemic in Egyptian poultry.

So far, eight H5N1 cases have been reported globally this year, all of them in Egypt. The WHO said since 2003, 854 cases have been reported, 450 of them fatal, from 16 countries.
Jul 19 WHO monthly flu at the human-animal interface report

In related developments, the WHO recently noted seven more H7N9 avian flu cases reported from China on Jul 12, four of them fatal. In a Jul 22 statement, the WHO said onset dates range from May 26 to Jun 23, with ages spanning 52 to 68 years.

The patients were from six provinces and cities. Four of the patients are men, and five reported exposure to poultry or their environments before they became ill. One worked a market where live poultry is sold. None of the cases reflect human-to-human transmission, the agency said.

Most of the cases had been noted earlier in other official reports from Chinese government agencies, according to FluTrackers, an infectious disease news message board. It put the global total at 800 cases since the first human cases were detected in 2012.
Jul 22 WHO statement on H7N9 in China
FluTrackers H7N9 case list


Iraq reports 11 H5 outbreaks affecting almost 3 million poultry

Iraqi officials today reported 11 outbreaks of highly pathogenic H5 avian flu outbreaks last month and this month that affected farm poultry numbering almost 3 million birds, while the government announced steps to combat the problem.

In a report to the World Organization for Animal Health (OIE), the country's Ministry of Agriculture reported that 11 farms in and around Baghdad were affected beginning on Jun 15, with the most recent one beginning on Jul 13. Seven were in Baghdad governorate, with the other 4 in Wasit governorate to the southeast of Baghdad.

The farms range in size from 17,000 to 914,000 birds. In total the farms housed 2,823,035 poultry, 512,948 of which died from the virus. The remaining 2.3 million birds were culled to prevent disease spread.

Officials are implementing control measures like disinfection of the premises and control poultry movement, the OIE report said.

In related news, Iraq's General Secretariat of the Council of Ministers ordered steps to combat the recent outbreaks, including limits on shipping animals, increased funding for containment, and reporting of sick birds. The statement was translated and posted by Avian Flu Diary, an infectious disease blog.
Jul 25 OIE report
Jul 25 Avian Flu Diary post

News Scan for Jul 25, 2016

News brief

WHO: Recent MERS cases linked to camels, healthcare settings

The Saudi Arabia Ministry of Health (MOH) reported two deaths from MERS-CoV (Middle East respiratory syndrome coronavirus) yesterday and today. The fatalities bring Saudi Arabia's total number of deaths from MERS-CoV since 2012 to 608.

Yesterday the MOH reported that a 27-year-old man from Buraydah had died, and today the MOH said a 44 year-old man from Najran died. Both men were expatriates and had primary exposure to the virus, meaning they did not contract MERS from another patient. Neither patient had any connection to the current outbreak at King Khalid University Hospital in Riyadh.

In other MERS news, today the World Health Organization (WHO) described nine cases of Saudi MERS diagnosed between Jul 2 and 14, including two deaths. Four of the cases involved indirect or direct exposure to camels, including consuming raw camel milk. Three of the cases were from Najran, and two were from Riyadh. Eight of the nine patients described had comorbidities at the time of infection, including both patients who died.

The organization said contact with camels, including drinking raw camel milk, remains a risk factor for contracting MERS. Camels can pass the virus to humans, but the exact route of transmission is still unknown.
Jul 25 MOH report
Jul 24 MOH report
Jul 25 WHO report

 

Merck's Ebola vaccine advances; evidence on virus shedding noted

Merck's vaccine against Ebola Zaire, V920, received a green light from both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA), the company announced today.

The FDA awarded the vaccine Breakthrough Therapy Designation, while the EMA labeled it a PRIME (PRIority MEdicines) medicine. Both awards are meant to speed the approval process for vaccines and medicines that target life-threatening diseases or unmet medical needs.

"The granting of Breakthrough Therapy Designation by the FDA and PRIME status by the EMA will enable us to continue to accelerate development of V920, and we greatly appreciate the collaboration of these agencies in moving this vaccine candidate forward in potentially meeting this public health need," said Paula Annunziato, MD, Merck's vice president for clinical research.
Jul 25 Merck press release

In other Ebola news, a study published last week in the Journal of Infectious Diseases described viral shedding and transmission levels of the disease in the wake of the 2014 outbreak, noting that, despite viral RNA presence in nearly all bodily fluids, some routes of transmission are more likely than others.

Swiss, US, and UK researchers conducted a comprehensive literature review and found that Ebola has been isolated and cultured from blood, saliva, urine, aqueous humor, semen, stool, and breast milk in infected patients. Viral RNA was found in breast milk 16 months after disease onset and in semen 18 months after initial diagnosis. Saliva and tears, however, contained Ebola RNA for only 22 and 28 days, respectively.

The authors concluded that transmission via the respiratory tract was unlikely, while transmission through sex, caregiving, and handling of cadavers was more likely to be the cause of infection.

Since late 2013, there have been more than 11,000 deaths and 28,500 cases of Ebola, almost all in West Africa.
Jul 20 J Infect Dis study

 

PAHO records 17,000 new chikungunya cases, mostly in Brazil

The Pan American Health Organization (PAHO) late last week reported 17,061 new suspected or confirmed chikungunya cases, bringing the total in the Americas this year to 212,839.

The previous two weekly PAHO updates noted just 903 and 1,479 cases, respectively.

The vast majority of new cases in the Jul 22 report were in Brazil, which reported 2 weeks' worth of data. The country notched 15,046 new cases, bringing its 2016 total to 137,808, which is by far the most of any country. Bolivia, the second hardest-hit nation, logged the second most cases last week. It had 1,190 new cases and 19,588 for the year.

PAHO reported 1 new chikungunya-related death last week, bringing the total for the year to 28, 17 of which have been in Brazil.

The chikungunya outbreak began in December 2013 on St. Martin in the Caribbean with the first recorded cases of the disease in the Americas.
Jul 22 PAHO update

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