The delay, narrowed approval, and extra study steps raise concerns about the status of and potential added requirements for other COVID vaccines.
Plaque growth can lead to a higher risk of heart attack, stroke, and other life-threatening cardiovascular events for as long as 1 year.
Post-exertional malaise, or exercise intolerance, was seen in 36% of those with long COVID.
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Minorities were underrepresented in both COVID-19 clinical treatment trials and in disease prevention trials.
Rebound was uncommon after use of the oral antivirals Paxlovid and molnupiravir to lower the risk of severe outcomes.
Protection was 35% among those vaccinated before contracting COVID-19.
Amid rising flu activity causing decade-high hospitalization rates, COVID-19 markers are also climbing.
Symptoms overall declined in a year, but some had symptoms for the first time at 6 and 12 months.
Nocebo is a phenomenon in which people experience negative effects when they have negative views or expectations.
As hospitalizations almost double, most states are experiencing high or very high flu levels.
The study highlights a likely high rate of asymptomatic disease spread.
"It is clear that ... healthcare services and policy need to prioritise long Covid care."
Data reflect about an 11% incidence of residual lung damage known as interstitial lung disease after COVID-19 hospitalization.
