Questions remain about how strictly Americans exposed to hantavirus on board the MV Hondius will need to be monitored by state health officials while quarantining at home.
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Both newly confirmed case-patients are receiving care in Spain.
The Netherlands has reported one more hantavirus infection in a crew member who left the MV Hondius cruise ship in the Canary Islands.
Three of the 10 patients described in the report died, and 2 of the other 7 remain hospitalized after infection with the Andes strain of the virus.
So far, no Americans have been sickened in this hantavirus outbreak.
The case count from the Dutch cruise outbreak remains at 11 cases, including three fatalities.
A case previously labeled as inconclusive has tested negative, WHO officials said.
"Respiratory person-to-person transmission is not new with the Andes hantavirus," Osterholm points out.