A study conducted in the Cleveland Clinic Health System found that antibiotic prescriptions for respiratory tract infections (RTIs) were 64% more common for virtual vs in-person urgent care settings, researchers reported today in Clinical Infectious Diseases.

Using electronic health record data and ICD-10 diagnostic codes, Cleveland Clinic researchers identified RTI patients who were treated through traditional in-person urgent care or the virtual urgent care platform from 2018 through 2022 and assessed whether the encounter resulted in an antibiotic prescription. COVID-19 encounters were excluded. They then used mixed effect logistics regression to model the odds of a patient receiving an antibiotic prescription by urgent care setting.

There were 69,189 visits to in-person urgent care and 19,003 visits to virtual urgent care during the study period, with 58% of virtual visits resulting in an antibiotic prescription compared with 43% of in-person visits. Sinusitis diagnoses were more than twice as common in virtual care versus in-person visits (34% vs 13%) and in both settings were associated with high rates of antibiotic prescribing (95% in-person, 91% virtual).

Multivariable analysis found that, compared with in-person urgent care, antibiotic prescribing was significantly more common in virtual urgent care visits (adjusted odds ratio [aOR], 1.64; 95% confidence interval [CI], 1.53 to 1.75). The results were similar in an analysis conducted among the 36 clinicians who saw patients in both settings (aOR, 1.71; 95% CI, 1.53 to 1.90). 

The platform may be the issue

The study authors say that the higher volume of antibiotic prescribing in virtual urgent care was likely driven by a higher rate of sinusitis diagnoses. But that may have more to do with the platform than the clinicians, they conclude.

"To our knowledge, this is the first to attempt to isolate the role of the platform in antibiotic prescribing," they wrote. "That we found higher prescribing in virtual care suggests that it is the limitations of the platform, and not the clinicians or the health system, that drive higher antibiotic prescribing."

They add that, given its rapid expansion, antibiotic stewardship interventions are needed in virtual urgent care settings.

That we found higher prescribing in virtual care suggests that it is the limitations of the platform, and not the clinicians or the health system, that drive higher antibiotic prescribing.

Only 1 in 4 polled participants in a new food safety survey from the Annenberg Public Policy Center (APPC) said they used a thermometer when cooking, and most are not clear about what temperature is needed to kill bacteria and viruses, including H5N1 avian flu viruses.

The survey, which also revealed low levels of drinking raw milk, was based on responses from 1,496 US adults collected from July 11 to 18. 

In total, 27% said they use a thermometers when cooking meat, poultry, and fish, and 29% said they "never" use a thermometer to check food temperatures, while 20% said they do "rarely" and 20% "sometimes."

Participants were also asked about if they consumed raw milk. The pasteurization process is known to kill the H5N1 avian flu virus currently affecting dairy herds across the country, and unpasteurized or raw milk has been identified as a possible source of animal-to-human transmission and has been linked to many cases of foodborne disease over the years. 

Only 3% drank raw milk

Only 3% of respondent said they consumed raw milk in the past year, with another 4% unsure of whether they had. 

The survey found that 15% of respondents thought drinking raw milk increases the chance of getting avian flu, while 33% said it had no effect one way or the other. Forty-nine percent said they were not sure.

When asked more questions about cooking measures aimed to prevent H5N1, 51% of those polled said they were not sure if any action items prevented the virus, including heating poultry, eggs, and ground beef to 165°F and heating steak to 145°F. 

Every cook should have a food thermometer within ready reach in the kitchen or near the grill.

"Using a food thermometer to determine that meat, poultry, fish, and eggs have been cooked to a safe internal temperature, one that kills bacteria such as E. coli and salmonella, is a way of protecting yourself from food poisoning," said Kathleen Hall Jamieson, PhD, director of the APPC, in a University of Pennsylvania press release. "Every cook should have a food thermometer within ready reach in the kitchen or near the grill."

Biological E, a vaccine and pharmaceutical company based in India, announced today that the World Health Organization has prequalified its novel oral poliovirus type 2 (nOPV2) vaccine, a next-generation vaccine for battling circulating vaccine-derived poliovirus type 2 (cVDPV2) outbreaks.

The company said the live attenuated oral vaccine has improved genetic stability and has a decreased chance of seeding new outbreaks in low-immunity settings compared to the Sabin poliovirus type 2 vaccine. It added that real-world deployment in outbreak regions suggests that it can successfully reduce the incidence of cVDPV2 outbreaks. 

Ability to produce 500 million doses a year

Biological E is making the vaccine in collaboration with Indonesia-based PT Bio Farma, which is the first manufacturer of the nOPV2 vaccine, which the WHO prequalified in January. The collaboration and support for production came from the Bill and Melinda Gates Foundation.

Biological E said its manufacturing facilities can produce more than 500 million doses of the vaccine each year.  Indian regulators have already cleared the vaccine for export purposes.

Infections involving circulating vaccine-derived polioviruses are rare, resulting from mutations that can occur when the virus spreads among unvaccinated groups. Cases have increased in recent years owing to low immunization rates in certain settings. 

Lung ultrasounds (LUS) can help clinicians quickly and accurately decide if a COVID-19 patient needs respiratory help, according to findings of a new international study reported in The Journal of Infectious Diseases.

The study took place from June 2020 to June 2023 at two major US military hospitals, a homeless shelter, emergency room, and in a referral hospital in rural Uganda. COVID-19 patients were given a 12-zone LUS at the time of enrollment as a point-of-care tool. 

LUS, the authors found, was a useful way to assess the top predictors of worsening disease, measured as cross-validated area under the curve (cvAUC). The top predictor was B-lines (cvAUC, 0.88; 95% confidence interval [CI], 0.87 to 0.90), discrete B-lines (0.87; 95% CI, 0.85 to 0.88), oxygen saturation (0.82; 95% CI, 0.81 to 0.84), and A-lines (0.80; 95% CI, 0.78 to 0.81).

Our results demonstrate that among individuals with COVID-19, point-of-care ultrasound is useful for triage decisions across a broad array of clinical settings

"Despite differences in patient populations, ultrasound clinical settings, and COVID era, B-lines in 25 to 50% of lung fields was consistently sensitive for identifying those at risk of progression and confluent B-lines in ≥25% of lung fields were specific," the authors wrote. "Our results demonstrate that among individuals with COVID-19, point-of-care ultrasound is useful for triage decisions across a broad array of clinical settings."