The incidence of cervical lesions was 50% lower in unvaccinated women when vaccination was widespread.
For the first time, the federal government has issued cervical cancer screening recommendations that include an option for home testing.
For those vaccinated against HPV before age 17, their rate of vaginal or vulvar precancers was 57% lower than for unvaccinated women.
The vaccine was 97% effective, and protection did not wane during the follow-up period.
The analysis draws on data from more than 132 million people.
Researchers say reliance on earmarked voluntary contributions from external donors like the Gates Foundation undermines the WHO's independence.
Home-based testing addresses screening barriers and can mitigate the impact of appointment backlogs and scheduling constraints on patients and healthcare systems, the authors say.
Between 2006 and 2023, vaccination rates reached 82%.
More than a third of US adults are unfamiliar with HPV, and more than 70% are unaware it causes oral cancers.
Uptake of the Tdap and MenACWY vaccines increased among 13- to 17-year-olds in 2024, while HPV vaccine coverage remained unchanged for the third straight year.
