MCR-1

Mobilized colistin resistance gene

Recent News

Jun 08, 2020
Chickens feeding in Guangdong, China

Study finds short-term impact of China's ban on colistin for animals

The ban on using colistin for growth promotion is tied to reduced MCR-1 in both animals and people.

Feb 13, 2020

News Scan for Feb 13, 2020

Recent DRC Ebola cases
MCR-1 resistance gene in Wyoming
Pneumococcal disease in kids
More H5N6 in Vietnam
Dec 11, 2019

Stewardship / Resistance Scan for Dec 11, 2019

Cefdinir antibiotic stewardship target
MCR colistin resistance in 2 nations
Oct 11, 2019

Stewardship / Resistance Scan for Oct 11, 2019

Probiotics and C diff risk
MCR genes on Algerian farms
Jul 25, 2019

Stewardship / Resistance Scan for Jul 25, 2019

Cost of hospital C diff
MCR-1, MCR-3 E coli combo
New resistant Pseudomonas cases
Jul 23, 2019
MRSA bacteria

Reports profile MCR gene in South America, first detection in Uruguay

Brazil, Bolivia, and Argentina had the most MCR-positive isolates, a review finds.

Jul 10, 2019

Stewardship / Resistance Scan for Jul 10, 2019

UK antibiotic prescribing decline
MCR-1 E coli in Michigan
Jun 14, 2019
Salmonella colonies in petrie dish

Colistin-resistance gene MCR-3.1 makes US appearance

The sample was from 2014, so the discovery has implications for the US spread of colistin resistance.

May 15, 2019

News Scan for May 15, 2019

UK veterinary stewardship policy
Improper prescribing in seniors
Resistant TB testing in China
Antibiotic production partnership
MCR-1 in chickens, camels
May 08, 2019

Stewardship / Resistance Scan for May 08, 2019

MCR-9 gene in Salmonella
Carbapenem de-escalation

Resources & Literature

Recent Literature

Alban V, Tamayo R, Villavicencio FX, et al. Canines with different pathologies as carriers of different lineages of Escherichia coli harboring mcr-1 and clinically relevant beta-lactamases in central Ecuador. J Glob Antimicrob Resist 2020 (published online Jun 6)

Chen FJ, Lauderdale TL, Huang WC, et al. Emergence of mcr-1, mcr-3, and mcr-8 in clinical Klebsiella pneumoniae isolates in Taiwan. Clin Microbiol Infect 2020 (published online Aug 6)

Hu Y, Fanning S, Nguyen SV, et al. Emergence of a Salmonella enterica serovar Typhimurium ST34 isolate, CFSA629, carrying a novel mcr-1.19 variant cultured from egg in China. J Antimicrob Chemother 2021 (published online Apr 5)

Kassem II, Mann D, Li S, et al. Draft genome sequences and resistome analysis of multidrug-resistant and mcr-1-harboring E. coli isolated from preharvest poultry in Lebanon. J Glob Antimicrob Resist 2021 (published online Mar 21)

Kilic A, Greene SR, Rojas LJ, et al. Detection of mcr-1 gene in a clinical Escherichia coli strain in North Carolina: first report. J Global Antimicrob Resist 2021 (published online Mar 28)

Li Y, Zhang Y, Chen M, et al. Plasmid-borne colistin resistance gene mcr-1 in a multidrug resistant Salmonella enterica serovar Typhimurium isolate from an infant with acute diarrhea in China. Int J Infect Dis 2020 (published online Nov 16)

Lin YC, Kuroda M, Suzuki S, et al. Emergence of the mcr-1 colistin resistance in ESBL-producing Klebsiella pneumoniae in Taiwan. J Global Antimicrob Resist 2021 (published online Jan 20)

Pan Y, Fang Y, Feng Y, et al. Discovery of mcr-3.1 gene carried by a prophage located in a conjugative IncA/C2 plasmid from a Salmonella Choleraesuis clinical isolate. J Infect 2020 (published online Sep 29)

Qin S, Zhang C, Schwarz S, et al. Identification of a novel conjugative mcr-8.2-bearing plasmid in an almost pan-resistant hypermucoviscous Klebsiella pneumoniae ST11 isolate with enhanced virulence. J Antimicrob Chemother 2020 (published online Jun 26)

Ruan Z, Jia H, Chen H, et al. Co-existence of plasmid-mediated tigecycline and colistin resistance genes tet(X4) and mcr-1 in a community-acquired Escherichia coli isolate in China. J Antimicrob Chemother 2020 (published online Aug 3)

Snyman Y, Reuter S, Whitelaw AC, et al. Characterisation of mcr-4.3 in a colistin-resistant Acinetobacter nosocomialis clinical isolate from Cape Town, South Africa. J Glob Antimicrob Resist 2021 (published online Mar 20)

Tansawai U, Yu Y, Kiddee A, et al. Emergence of mcr-3-mediated IncP and IncFII plasmids in Thailand. J Global Antimicrob Resist 2021 (published online Feb 19)

Vasconcelos PC, Leite EL, Araujo WJ, et al. Draft genome sequence of mcr-1-mediated colistin-resistant Escherichia coli ST359 from chicken carcasses in Northeastern Brazil. J Glob Antimicrob Resist 2020 (published online Sep 11)

Wu B, Wang Y, Ling Z, et al. Heterogeneity and diversity of mcr-8 genetic context in chicken-associated Klebsiella pneumoniae. Antimicrob Agents Chemother 2020 (published online Oct 12)

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