Tuberculosis

Recent News

Jul 06, 2020

News Scan for Jul 06, 2020

More DRC Ebola deaths
MERS in Saudi Arabia
Underlying conditions and COVID-19
Price cut for drug-resistant TB drug
May 20, 2020
TB testing

Review finds test antibiotics unreliable for diagnosing TB

A long-standing practice of using antibiotics to test for TB is unreliable for diagnosing the disease.

May 13, 2020

News Scan for May 13, 2020

Legal liability of stewardship programs
Global life expectancy gains
May 06, 2020
Tuberculosis screening in India

Experts warn COVID-19 lockdowns could have dire impact on TB

A modest lockdown could add 1.8 million TB cases and 342,000 deaths globally over 5 years.

Apr 28, 2020

News Scan for Apr 28, 2020

Mass azithromycin distribution in Malawi
Rapid MDR-TB susceptibility test
Flu tapers in Northern Hemisphere
Mar 24, 2020
Miliary tuberculosis lung damage

As COVID-19 rages, WHO calls for more efforts to prevent TB

The WHO urges nations to maintain continuity of TB services as they respond to COVID-19.

Mar 05, 2020

News Scan for Mar 05, 2020

More MERS in Saudi Arabia
Drug trial for highly resistant TB
Urine culture order intervention
Antibiotic use, resistance in African food animals
Jan 02, 2020

News Scan for Jan 02, 2020

Malaria in Burundi
Intravenous TB vaccine study
H5N8 avan flu in Poland
Dec 16, 2019

Stewardship / Resistance Scan for Dec 16, 2019

BARDA funding for antibiotic candidates
Drug-resistant TB treatment recommendations
Disposable duodenoscope approval
Dec 10, 2019
Child with TB and doctor

Reports: Tuberculosis R&D funding still falling short

Global funding has reached an all-time high but falls far short of what's needed to eliminate TB.

Resources & Literature

Recent Literature

Abdulkareem FN, Merza MA, Salih AM. First insight into latent tuberculosis infection among household contacts of tuberculosis patients in Duhok, Iraqi Kurdistan: using tuberculin skin test and QuantiFERON-TB Gold Plus test. Int J Infect Dis 2020 (published online Mar 31)

Ahmad R, Xie L, Pyle M, et al. A rapid test for active pulmonary tuberculosis in adult patients with persistent cough. Sci Transl Med 2019 Oct 23;11(515):eaaw8287

Aibana O, Huang CC, Aboud S, et al. Vitamin D status and risk of incident tuberculosis disease: a nested case-control study, systematic review, and individual-participant data meta-analysis. PLOS Med 2019 Sep 11;16(9):e1002907

Bao H, Liu K, Wu Z, et al. Tuberculosis outbreaks among students in mainland China: a systematic review and meta-analysis. BMC Infect Dis 2019 Nov 14;19:972

Bastos ML, Campbell JR, Oxlade O, et al. Health system costs of treating latent tuberculosis infection with four months of rifampin versus nine months of isoniazid in different settings. Ann Intern Med 2020 (published online Jun 16)

Becerra MC, Huang CC, Lecca L, et al. Transmissibility and potential for disease progression of drug resistant Mycobacterium tuberculosis: prospective cohort study. BMJ 2019 (published online Oct 24)

Berrocal-Almanza LC, Harris R, Lalor MK, et al. Effectiveness of pre-entry active tuberculosis and post-entry latent tuberculosis screening in new entrants to the UK: a retrospective, population-based cohort study. Lancet Infect Dis 2019 (published online Aug 27)

Boardman NJ, Moore T, Freiman J, et al. Pulmonary tuberculosis disease among immigrant detainees: rapid disease detection, high prevalence of asymptomatic disease and implications for tuberculosis prevention. Clin Infect Dis 2020 (published online Apr 16)

Brigden G, Nhung NV, Skrahina A, et al. Advances in clinical trial design for development of new TB treatments — translating international tuberculosis treatment guidelines into national strategic plans: experiences from Belarus, South Africa, and Vietnam. PLOS Med 2019 Oct 18;16(10):e1002896

Campbell JR, Winters N, Menzies D. Absolute risk of tuberculosis among untreated populations with a positive tuberculin skin test or interferon-gamma release assay result: systematic review and meta-analysis. BMJ 2020;368:m549

Camprubi D, Gomila A, Grijota-Camino MD, et al. Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by real-time polymerase chain reaction, Xpert MTB/RIF. J Infect 2020 (published online Jan 16)

Chisompola NK, Streicher EM, Muchemwa CM, et al. Molecular epidemiology of drug resistant Mycobacterium tuberculosis in Africa: a systematic review. BMC Infect Dis 2020 May 13;20:344

Conradie F, Diacon AH, Ngubane N, et al. Treatment of highly drug-resistant pulmonary tuberculosis. N Engl J Med 2020 (published online Mar 5)

Dadu A, Hovhannesyan A, Ahmedov S, et al. Drug-resistant tuberculosis in eastern Europe and central Asia: a time-series analysis of routine surveillance data. Lancet Infect Dis 2019 (published online Nov 26)

Darrah PA, Zeppa JJ, Maiello P, et al. Prevention of tuberculosis in macaques after intravenous BCG immunization. Nature 2020 Jan 1;577:95-102

Dean AS, Zignol M, Cabibbe AM, et al. Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: a multicountry analysis of cross-sectional data. PLOS Med 2020 Jan 21;17(1):e1003008

Der JB, Grint D, Narh C. Where are patients missed in the tuberculosis diagnostic cascade? A prospective cohort study in Ghana. PLoS One 2020 (published online Mar 19)

Divala TH, Fielding KL, Kandulu C, et al. Utility of broad-spectrum antibiotics for diagnosing pulmonary tuberculosis in adults: a systematic review and meta-analysis. Lancet Infect Dis 2020 (published online May 18)

Du Y, Qiu C, Chen X, et al. Treatment outcome of a shorter regimen containing clofazimine for multidrug-resistant tuberculosis: a randomized control trial in China. Clin Infect Dis 2019 (published online Sep 24)

Feng JY, Huang WC, Lin SM, et al. Safety and treatment completion of latent tuberculosis infection treatment in elderly population—a prospective observational study in Taiwan. Int J Infect Dis 2020 (published online May 17)

Flynn AG, Aiona K, Haas MK, et al. Clinical characteristics of active tuberculosis diagnosed after starting treatment for latent tuberculosis infection. Clin Infect Dis 2019 (published online Nov 27)

Gao M, Gao J, Xie L, et al. Early outcome and safety of bedaquiline-containing regimens for treatment of MDR- and XDR-TB in China: a multicentre study. Clin Microbiol Infect 2020 (published online Jun 14)

Guthmann JP, Leon L, Antoine D, et al. Tuberculosis treatment outcomes of notified cases: trends and determinants of potential unfavourable outcome, France, 2008 to 2014. Euro Surveill 2020 Jan 30;25(4):pii=1900191

Hao X, Lou H, Bai J, et al. Cost-effectiveness analysis of Xpert in detecting Mycobacterium tuberculosis: a systematic review. Int J Infect Dis 2020 (published online Apr 9)

Hermans SM, Zinyakatira N, Caldwell J, et al. High rates of recurrent TB disease: a population-level cohort study. Clin Infect Dis 2020 (published online Apr 25)

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