CARB-X to fund development of rapid test for chlamydia, gonorrhea
CARB-X announced today that it is awarding Australian diagnostics company SpeeDx up to $1.8 million to develop a rapid molecular diagnostic test for chlamydia and gonorrhea infections.
The money will aid development of SpeeDx's InSignia technology, which is able to detect whether an active infection is associated with Chlamydia trachomatis or Neisseria gonorrhoeae within 60 minutes. The technology will also be able to perform antibiotic susceptibility testing to identify the most appropriate antibiotic for gonorrhea infections.
SpeeDx, of Sydney, Australia, plans to combine the test with a battery powered, easy-to-use device developed by QuantuMDx that can be used in remote or low-resource settings such as sub-Saharan Africa, where the vast majority of gonorrhea infections go undetected and untreated. If the project achieves certain milestones, it could be eligible for $1.9 million in additional funding from CARB-X (the Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator).
"SpeeDx's technology is in the early stages of development and, if successful, could be used to help healthcare providers rapidly diagnose chlamydia and gonorrhea, and to identify antibiotics that could be effective, thus improving treatment decisions, and mitigating the devastating effects of these diseases," CARB-X Research and Development Chief Erin Duffy, PhD, said in a CARB-X press release. "Faster diagnostics have the potential to help inform treatment decisions, and those diagnostics that can be deployed in low-resource settings are sorely needed."
May 11 CARB-X press release
Hospital pathogens in Vietnam show increasing resistance levels
Analysis of surveillance data from hospitals in Vietnam found alarmingly high and increasing levels of antibiotic resistance in clinically important organisms, researchers reported yesterday in Antimicrobial Resistance and Infection Control.
Among the 42,553 bacterial isolates collected from 13 Vietnamese hospitals in 2016-17 by Vietnam's national antimicrobial resistance (AMR) surveillance network, 71% were gram-negative and 29% were gram-positive. Escherichia coli (21%) and Staphylococcus aureus (11%) were the most frequently detected species, followed by Klebsiella pneumoniae (9.1%) and Acinetobacter baumannii (9%).
Antibiotic susceptibility data showed that, among gram-positive bacteria, 73% of S aureus isolates were methicillin-resistant, 34% of Enterococcus faecium were resistant to vancomycin, and 58% of Streptococcus pneumoniae had reduced susceptibility to penicillin.
Among gram-negative bacteria, 59% of E coli and 40% of K pneumoniae produced extended-spectrum beta-lactamase (ESBL) enzymes, and 29% and 11% were resistant to carbapenems, respectively. In addition, 79% of Acinetobacter spp. and 45% of Pseudomonas aeruginosa were carbapenem resistant, and 88% of Haemophilus influenzae were resistant to ampicillin.
When compared with data collected from the same hospitals in 2012-13, the proportion of antibiotic-resistant isolates were higher in 2016-17 for most pathogen-antibiotic combinations of interest, including imipenem-resistant A baumannii, P aeruginosa, and Enterobacterales. The proportion of multidrug-resistant E coli, A baumannii, and P aeruginosa was also higher.
The study authors note that the findings may not reflect the true prevalence of antibiotic resistance because of sampling biases and because they did not know whether the isolates were from hospital- or community-acquired infections.
May 10 Antimicrob Resist Infect Control study
Uganda reports Crimean-Congo fever cluster at refugee camp
Uganda has reported a Crimean-Congo hemorrhagic fever (CCHF) outbreak, which involves two confirmed cases at a refugee settlement in Kikuube region in the country's western region, the World Health Organization (WHO) African regional office said in its latest weekly outbreaks and health emergencies report.
The first case was confirmed on Apr 28 in a 16-year-girl who sought care at a healthcare facility after experiencing fever with hemorrhagic symptoms that included vomiting and nosebleeds. An investigation found that her family raises goats. The virus that causes CCHF is known to circulate in the country's livestock.
A second epidemiologically linked case was detected and involves a 13-year-old boy who had similar symptoms. Both patients are recovering and are listed in stable condition.
No other suspected cases have been reported, and so far, 144 contacts are being monitored. The outbreak response includes mass spraying of livestock, managing human cases, and increasing supplies of ribavirin and personal protective equipment.
The CCHF virus is carried by ticks, which can pass the disease to cattle, sheep, goats, and rabbits. People can contract infections through tick bites or contact with the blood of infected animals. The virus can also spread from person to person by body fluids.
May 10 WHO African regional office weekly outbreaks and emergencies bulletin