The rate was quadruple in those 75 and older, but those findings demonstrate less statistical power.
Vaccination was 82% effective against hospital admission for any RSV-related respiratory illness and 87% effective against admission for severe RSV.
The findings have implications for scheduling repeat dosing in eligible children, the authors say.
Our systematic review published this week shows that rigorous, transparent evidence synthesis can persist even when traditional advisory processes falter.
The large-scale project was conducted by the Center for Infectious Disease Research and Policy's Vaccine Integrity Project.
The overall estimated RSV incidence in young children was about 3 times higher in ambulatory care than in emergency departments.
Adjusted effectiveness against emergency department visits/hospitalizations was 95% among patients aged 75 and older.
HEPA purifiers were associated with a 33% decrease in viral diversity, but the reduction wasn't linked to fewer school absences.
But there is 'substantial opportunity' for load-balancing strategies during future pediatric hospital surges to reduce bed strain and harm, the authors say.
The Vaccine Integrity Project staff and advisors note the conspicuous and consequential absence of US health agency vaccine campaigns and annual vaccination reminders ahead of respiratory virus season.
