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Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

MCR-1 identified in California; Vietnam notes link to ag colistin use

Originally published by CIDRAP News Feb 1

H7N9 hospitalizes man in China's Henan province

One more H7N9 avian flu infection was reported from China today, a sign of ongoing activity that is within striking distance of the record 319 cases reported during the second wave of activity during the winter of 2013-14.

Chinese study finds increasing rate of MCR-1 carriage in humans

A new study out of China indicates that human fecal carriage of MCR-1-positive, multidrug-resistant Enterobacteriaceae is on the rise.

Brazil's yellow fever outbreak tops 1,000 cases

A worrisome spike of more than 300 yellow fever cases in the past week has boosted Brazil's outbreak to 1,060 cases and 166 deaths, the country's health ministry said in an update yesterday.

Study shows how tolerant bacteria enable the development of resistance

Researchers from the Hebrew University of Jerusalem and the Massachusetts Institute of Technology have uncovered an alternative method by which bacteria can become resistant to antibiotics.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Study shows how tolerant bacteria enable the development of resistance

Researchers from the Hebrew University of Jerusalem and the Massachusetts Institute of Technology have uncovered an alternative method by which bacteria can become resistant to antibiotics.

H7N9 cases detected in Beijing and Shanghai

The H7N9 avian influenza virus has sickened two more people in China. The infections were detected in two of the country's biggest cities: Beijing and Shanghai.

DRC declares yellow fever outbreak over

Today the World Health Organization (WHO) declared that the yellow fever outbreak in the Democratic Republic of the Congo (DRC) is over, based on an announcement from the DRC. The declaration follows Angola's Dec 23 announcement that the outbreak had ended in that country. The DRC reported its last case on Jul 12, 2016.

Experts recommend strategies for successful stewardship

An article yesterday in Clinical Infectious Diseases aims to help healthcare institutions comply with newly mandated antimicrobial stewardship standards by highlighting the habits of successful antimicrobial stewardship programs.

H5N8 avian flu outbreaks expand in Israel, Europe

Israel and four European countries reported more highly pathogenic H5N8 outbreaks, according to the latest updates from the World Organization for Animal Health (OIE). Israel reported six new outbreaks in the central part of the country, with start dates ranging from Jan 23 to Feb 12, five of them at farms (turkeys, ducks, and laying hens) and one involving three barn owls found dead at a nature park.

Daptomycin shown to be safe, effective in kids with MRSA skin infections

Daptomycin is well-tolerated and effective in children with invasive methicillin-resistant Staphylococcus aureus (MRSA) skin infections, according to the results of a clinical trial published this week in Pediatrics.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Daptomycin shown to be safe, effective in kids with MRSA skin infections

Daptomycin is well-tolerated and effective in children with invasive methicillin-resistant Staphylococcus aureus (MRSA) skin infections, according to the results of a clinical trial published this week in Pediatrics.

Officials confirm 6 new MERS cases, 1 death in Saudi Arabia

Over the past 4 days, Saudi Arabia's Ministry of Health (MOH) reported a flurry of MERS cases, one of them fatal and all involving men.

Neonatal sepsis risk calculator nearly halves newborn antibiotic use

An online calculator that predicts the risk for early onset sepsis (EOS) can cut antibiotic use in newborns nearly in half, according to a study yesterday in JAMA Pediatrics.

Study describes incidence, risk factors for MDR Enterobacteriaceae in kids

A study yesterday in BMC Infectious Diseases shows that critically ill children with tracheal Enterobacteriaceae infection are at risk for multidrug-resistant (MDR) infections.

Scientists report first case of artemisinin-resistant malaria in Africa

The first known case of malaria resistant to the essential drug artemisinin was reported yesterday in the New England Journal of Medicine.

FDA clears two diagnostic tests for expanded use, marketing

The US Food and Drug Administration (FDA) yesterday cleared the expanded use of a diagnostic test for lower respiratory tract infections and sepsis and allowed marketing for a test that can identify organisms that cause bloodstream infections, according to two agency news releases.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

WHO calls for R&D into drug-resistant tuberculosis treatment

The World Health Organization (WHO) issued a statement today reaffirming the need for more research and development on new antibiotics for multidrug-resistant tuberculosis (MDR-TB).

Study: Prior antibiotic use may raise risk of resistant urinary tract infections

Receiving two or more antibiotic regimens is associated with an increased risk of gram-negative pathogens in patients with hospital-onset urinary tract infections (UTIs), according to a study yesterday in BMC Infectious Diseases.

US study shows Zika-type birth defects rise 20-fold

The incidence type of birth defects seen with congenital Zika infections in the United States rose 20 times higher than it was before the virus started circulating in the Americas region, researchers reported today in the latest issue of Morbidity and Mortality Weekly Report (MMWR).

GAO urges more FDA guidance on new antibiotic development

A new report from the US Government Accountability Office (GAO) says the Food and Drug Administration (FDA) needs to provide more guidance to drug companies on how to use incentives to develop new antibiotics.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

GAO urges more FDA guidance on new antibiotic development

A new report from the US Government Accountability Office (GAO) says the Food and Drug Administration (FDA) needs to provide more guidance to drug companies on how to use incentives to develop new antibiotics.

Study makes case for 'watchful waiting' approach to kids' ear infections

Appropriate use of the "watchful waiting" strategy for management of acute otitis media (AOM) in children could reduce healthcare costs and improve health outcomes, according to a new study in Pediatrics.

Blood donor screening finds 13% Zika rate in Puerto Rico last year

In a study that expands on an earlier analysis, screening of blood donations in Puerto Rico last spring and summer found a 13% incidence of Zika virus, according to a study yesterday in Emerging Infectious Diseases.