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Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

PAHO: cephalosporin-resistant gonorrhea present in 4 Americas countries

The United States, Brazil, Argentina, and now Canada, have all reported cases of cephalosporin-resistant gonorrhea, according to the latest situation report published by the Pan American Health organization (PAHO).

Congress urged to provide incentives for antibiotic development

The Infectious Diseases Society of America (IDSA) today released a letter urging Congress to provide new economic incentives for the development of new antimicrobial drugs.

Survey finds knowledge and practice gaps among antibiotic prescribers

An online survey of frontline prescribers found mostly positive attitudes toward antimicrobial stewardship programs (ASPs) but also identified several specific deficiencies related to knowledge, prescribing practices, and awareness of available resources, according to a study yesterday in Infection Control and Hospital Epidemiology.

Study indicates yaws elimination strategy needs modification

A longitudinal study in Papua New Guinea has found that mass administration of antibiotics followed by targeted treatment did not eliminate yaws, researchers reported yesterday in The Lancet. The study also discovered the first signs of resistance in the tropical infection, which causes chronic disfiguring skin ulcers in children in at least 14 countries.

VHA papers propose research agendas in 4 areas of antibiotic resistance

A series of papers yesterday in Infection Control and Hospital Epidemiology by researchers and clinicians with the Veterans Health Administration (VHA) identifies key knowledge gaps and lays out research agendas to address the spread of drug-resistant pathogens in healthcare settings.

VHA papers propose research agendas in 4 areas of antibiotic resistance

A series of papers yesterday in Infection Control and Hospital Epidemiology by researchers and clinicians with the Veterans Health Administration (VHA) identifies key knowledge gaps and lays out research agendas to address the spread of drug-resistant pathogens in healthcare settings.

Survey suggests end-of-life situations affect views on antibiotic use

The results of a survey of physicians published today in Infection Control and Hospital Epidemiology indicate that when treating patients at the end of life, physicians' decisions about continuing antimicrobial use are influenced by many factors.

Italian researchers identify 26 E coli isolates with MCR-1 resistance gene

Italian scientists this week reported detecting the MCR-1 colistin-resistance gene in 26 Escherichia coli isolates among more than 19,000 Enterobacteriaceae that they tested as part of surveillance efforts in Romagna in northern Italy.

Trial finds no benefit of combo drugs for severe carbapenem-resistant infections

In patients hospitalized with serious infections from carbapenem-resistant gram-negative bacteria, a combination of colistin and meropenem wasn't associated with fewer clinical failures compared with colistin alone, researchers reported today in The Lancet Infectious Diseases.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

CARB-X announces first award for 2018, two more funding rounds

CARB-X, a public-private collaboration that supports companies in early-stage antibiotic discovery and development, recently announced its first funding award for 2018 and provided details about two funding rounds for the current year.

Platform uses metabolomic analysis to uncover novel antibiotics

A study today in Science Translational Medicine describes a new approach to determining the modes of action underlying antimicrobial compounds that could help speed the process of discovering novel antibiotics.

Study evaluates cost-effectiveness of Clostridium difficile treatments

A systematic review of treatments for Clostridium difficile infection (CDI) yesterday in Infection Control and Hospital Epidemiology concludes that the most cost-effective treatment remains unclear.

Belgian study reports high rate of improper antibiotic prescribing in kids

Belgian researchers report that almost a third of prescriptions for fluoroquinolones written for hospitalized children were deemed inappropriate, according to a study today in BMC Infectious Diseases.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Belgian study reports high rate of improper antibiotic prescribing in kids

Belgian researchers report that almost a third of prescriptions for fluoroquinolones written for hospitalized children were deemed inappropriate, according to a study today in BMC Infectious Diseases.

Nigeria Lassa fever outbreak grows, with 68 new cases reported

The Lassa fever outbreak in Nigeria continues this week with 68 new confirmed cases, including 4 deaths, according to the latest weekly update by the World Health Organization (WHO) Regional Office for Africa. That's up from 19 confirmed cases the week before.

Two groups laud Senate bill to combat antimicrobial resistance

Two major infectious disease groups voiced strong support of a bill introduced yesterday to strengthen the US government's response to the growing threat of antimicrobial resistance (AMR).

Survey finds low use of antibiograms among medical residents

A survey of medical residents found that 28% to 51% could not accurately identify pathogens to target with empiric therapy or select therapy with an appropriate spectrum of activity, and only 12% of respondents identified antibiograms as a prescribing resource, according to a study yesterday in Infection Control & Hospital Epidemiology.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Four countries report more H5N8, H5N1 avian flu outbreaks in poultry

Three countries—Bulgaria, the Democratic Republic of Congo (DRC), and Iraq—recently reported more highly pathogenic H5N8 outbreaks, and Cambodia confirmed another H5N1 detection at a farm in Phnom Penh.

Klebsiella with MCR-1, carbapenemase genes found in Portuguese patients

Researchers in Portugal have identified 16 patients from a previously unnoticed hospital outbreak with carbapenemase-producing and MCR-1-producing Klebsiella pneumoniae, according to a case report yesterday in Emerging Infectious Diseases.

Italian study finds large reservoir of MDR bacteria in nursing homes

Researchers in Italy report widespread diffusion of multidrug-resistant (MDR) bacteria in residents from long-term care facilities (LTCFs) in three different northern Italian regions, according to a study yesterday in Antimicrobial Resistance and Infection Control.

Study finds widespread, arbitrary antimicrobial use in Cambodian pigs

A study yesterday in Antimicrobial Resistance and Infection Control reports widespread and arbitrary use of antibiotics on small-scale pig farms in Cambodia.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Study finds widespread, arbitrary antimicrobial use in Cambodian pigs

Originally published by CIDRAP News Mar 8

A study yesterday in Antimicrobial Resistance and Infection Control reports widespread and arbitrary use of antibiotics on small-scale pig farms in Cambodia.