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FDA to review new treatments for urinary tract infections, pneumonia

Merck announced yesterday that the US Food and Drug Administration has accepted for priority review a New Drug Application (NDA) for the combination of relebactam and imipenem/cilastatin and a supplemental NDA for Zerbaxa (ceftolozane and tazobactam).

Study: Inadequate drug-susceptibility tests linked to poor TB treatment

The accuracy of tuberculosis (TB) drug-susceptibility testing in high-burden countries was inadequate, and inaccurate test results led to inadequate treatment that contributed to higher mortality in patients with drug-resistant forms of the disease, an international team of researchers reported yesterday in The Lancet Infectious Diseases.

Study: Inadequate drug-susceptibility tests linked to poor TB treatment

The accuracy of tuberculosis (TB) drug-susceptibility testing in high-burden countries was inadequate, and inaccurate test results led to inadequate treatment that contributed to higher mortality in patients with drug-resistant forms of the disease, an international team of researchers reported yesterday in The Lancet Infectious Diseases.

CDC: 19 states may have raw milk exposure to drug-resistant Brucella

Today the Centers for Disease Control and Prevention (CDC) announced that health workers are investigating potential exposures to a drug-resistant Brucella strain RB51 in 19 states. The strain comes from raw (unpasteurized) milk from Miller's Biodiversity Farm in Quarryville, Penn.

Study: Hospital readmission for Staph bacteremia patients common, costly

New research by scientists with the University of Mississippi Medical Center indicates that 30-day hospital readmission among patients who survived initial hospitalization with Staphylococcus aureus bloodstream infections is common and costly. The findings appeared yesterday in Clinical Infectious Diseases.

Dental antibiotic stewardship program shows promising results

A team of dentists, pharmacists, and physicians at the University of Illinois reported today in Open Forum Infectious Diseases that implementation of a comprehensive antibiotic stewardship intervention in a dental practice was associated with a significant improvement in antibiotic prescribing.

Survey finds low postgrad stewardship training in pharmacists, nurses

British investigators conducted an international survey and found that postgraduate training and support in antibiotic prescribing remain low among nurses and pharmacists, and, although antibiotic policies and committees are established in most institutions, surveillance of antibiotic use is not, according to a new report in Antimicrobial Resistance & Infection Control.

Digital stewardship cuts antibiotics for respiratory infections in UK study

Electronically delivered prescribing feedback and decision support interventions reduced antibiotic prescribing for respiratory infection (RTI) in adults by 12%, according to the results of a clinical trial published this week in the British Medical Journal.

Digital stewardship cuts antibiotics for respiratory infections in UK study

Electronically delivered prescribing feedback and decision support interventions reduced antibiotic prescribing for respiratory infection (RTI) in adults by 12%, according to the results of a clinical trial published this week in the British Medical Journal.

Resistance genes found in soil 2 years after cattle operation ceases

A new study led by scientists from US Department of Agriculture (USDA) found that antibiotic resistance genes persist in a beef cattle environment even 2 years after cessation of operations.

Nursing home stewardship program focuses on undocumented UTIs

An antimicrobial stewardship intervention targeted to rural nursing homes in Alberta, Canada, significantly decreased the level of urine culture testing and antibiotic prescribing without an increase in hospitalization or mortality, Canadian researchers reported today in Infection Control and Hospital Epidemiology.

Genomic analysis shows UK, Australian XDR gonorrhea cases are related

An international team of scientists reported today in Eurosurveillance that the three extensively drug-resistant (XDR) gonorrhea cases identified in Australia and the United Kingdom in 2018 were caused by a single XDR clone.

Nursing home survey highlights antibiotic overuse for skin infections

A study today in Epidemiology and Infection reports that less than a third of the residents in Australian nursing homes who were prescribed an antimicrobial for a skin infection had a confirmed bacterial infection.

Nursing home survey highlights antibiotic overuse for skin infections

A study today in Epidemiology and Infection reports that less than a third of the residents in Australian nursing homes who were prescribed an antimicrobial for a skin infection had a confirmed bacterial infection.

Antibiotic eye drops linked to shorter symptom duration for conjunctivitis

A randomized clinical trial and meta-analysis of previous trials found that topical antibiotics were associated with significantly shorter symptom duration in children with acute infective conjunctivitis, researchers reported today in JAMA Network Open.

BARDA to fund development of antibiotic for melioidosis

Venatorx Pharmaceuticals announced this week that it has received a contract from the US Department of Health and Human Services (HHS) Biomedical Advanced Research and Development Authority (BARDA) to develop the combination antibiotic cefipime-taniborbactam for treatment of melioidosis.

Trial supports shorter antibiotic course for Lyme symptoms

The results of a randomized clinical trial in Slovenia suggest that a 7-day course of antibiotics for a rash caused by Lyme disease is noninferior to a 14-day course, researchers reported yesterday in The Lancet Infectious Diseases.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Trial supports shorter antibiotic course for Lyme symptoms

The results of a randomized clinical trial in Slovenia suggest that a 7-day course of antibiotics for a rash caused by Lyme disease is noninferior to a 14-day course, researchers reported yesterday in The Lancet Infectious Diseases.

Non-prescription antibiotic dispensing common in Ethiopian pharmacies

A simulated client study in Ethiopia found a high rate of non-prescription antibiotic dispensing at community pharmacies, researchers reported today in the Journal of Antimicrobial Chemotherapy.

Report: Carbapenemase-producing Enterobacterales rose in Latin America

A report today in Emerging Infectious Diseases highlights increased detection of carbapenemase-producing Enterobacterales (CPE) in Latin America and the Caribbean during the COVID-19 pandemic.

Concerning rise found in last-resort antibiotic use in European hospitals

A study of antibiotic consumption in European hospitals found increasing use of antibiotics reserved for the most difficult-to-treat infections, researchers reported yesterday in Eurosurveillance.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Concerning rise found in last-resort antibiotic use in European hospitals

A study of antibiotic consumption in European hospitals found increasing use of antibiotics reserved for the most difficult-to-treat infections, researchers reported yesterday in Eurosurveillance.

Study: Antimicrobial resistance rates rose in US hospitals during COVID-19

A new analysis of data on US hospital patients during the COVID-19 pandemic finds that patients tested for SARS-CoV-2 had a higher rate of antimicrobial resistance (AMR), researchers reported today in Open Forum Infectious Diseases.

New toolkit aims to improve ambulatory antibiotic prescribing

The US Agency for Healthcare Research and Quality (AHRQ) yesterday released a new toolkit to help hospitals improve antibiotic use in ambulatory care.

Prolonged COVID test positivity in symptomatic, Omicron BA.2 infections

Among a group of vaccinated college athletes who tested positive for COVID-19 and underwent rapid antigen testing 7 days later, 27% were still positive—a proportion that climbed to 35% in symptomatic athletes and 40% in those infected with the Omicron BA.2 subvariant.