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More stewardship needed for postoperative antibiotics in kids, study finds

A multicenter observational study found that the use of antibiotics after nonemergent surgery in children varied widely across US hospitals but was not correlated with skin site infection (SSI) in children, US researchers reported yesterday in JAMA Surgery.

Survey: A third of US military find exercise difficult 1 month post-COVID

A third of US active-duty military service members who tested positive for COVID-19 reported new-onset or more difficulty with exercise and daily activities 1 month after diagnosis, but these symptoms diminished to pre-infection levels after 6 to 9 months, according to research presented at this week's Infectious Diseases Society of America (IDSA) ID Week in Washington, DC.

Microbiome drug for recurrent C difficile shows durable response

A secondary analysis of results from a phase 3 trial shows that an investigative microbiome therapeutic reduced rates of recurrent Clostridioides difficile infection (rCDI) through 24 weeks and was well-tolerated, researchers reported this week in JAMA.

Flu contributing to inappropriate antibiotics for respiratory infections

An analysis of patients in a California health system found relatively high rates of flu-associated prescribing of select antibiotics in certain age-groups, researchers reported today in Epidemiology & Infection.

Poor outcomes seen in those with resistant E coli bloodstream infections

An analysis of patients with Escherichia coli bloodstream infections (BSIs) found notably poorer outcomes in those with ceftriaxone-resistant infections, US researchers reported yesterday in Open Forum Infectious Diseases.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Report highlights animal transport as risk for spread of resistant bacteria

A report last week from the European Food Safety Authority (EFSA) suggests steps could be taken to limit the spread of antimicrobial resistance (AMR) in food-producing animals during transportation.

WHO keeps monkeypox public health emergency in place

The World Health Organization (WHO) monkeypox emergency committee met for the third time on Oct 20 to discuss the latest developments, concluding that the situation still warrants a public health emergency of international concern (PHEIC).

Procalcitonin trends linked to antibiotic use, duration in COVID-19 patients

A study of hospitalized COVID-19 patients in Michigan found that procalcitonin (PCT) trends were associated with the decision to initiate antibiotics and duration of treatment, independent of bacterial pneumonia (bPNA) status, researchers reported today in Infection Control & Hospital Epidemiology.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Study finds most outpatient antibiotics in China are inappropriate

Originally published by CIDRAP News Jan 28

More than half of outpatient antibiotic prescriptions at Chinese hospitals over a 3.5-year period were inappropriate, Chinese researchers reported yesterday in The Lancet Infectious Diseases.

CARB-X to fund development of electronic antibiotic susceptibility test

CARB-X announced today that it is awarding up to $2.5 million to Avails Medical of Menlo Park, California, to develop an electronic antibiotic susceptibility test (eAST).

VHA hospital study shows benefits of carbapenem-specific stewardship

An assessment of 90 Veterans Health Administration (VHA) hospitals found that carbapenem-specific stewardship strategies were associated with a lower volume of carbapenem use and more appropriate carbapenem prescribing, researchers reported yesterday in the Journal of Antimicrobial Chemotherapy.

CARB-X funds work on novel antibiotic for carbapenem-resistant pathogens

CARB-X announced today that it is awarding up to $6.4 million to French biopharmaceutical firm Mutabilis to develop a new class of antibiotics to treat infections caused by carbapenem-resistant Enterobacterales (CRE) bacteria.

Stewardship intervention linked to more appropriate ER prescribing

A multifaceted intervention implemented in a Japanese emergency department was associated with reduced antibiotic prescribing at discharge and an increase in appropriate prescribing, Japanese researchers reported today in Infection Control and Hospital Epidemiology.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Stewardship intervention linked to more appropriate ER prescribing

A multifaceted intervention implemented in a Japanese emergency department was associated with reduced antibiotic prescribing at discharge and an increase in appropriate prescribing, Japanese researchers reported today in Infection Control and Hospital Epidemiology.

DRC reports new Ebola case in earlier outbreak hot spot

The Democratic Republic of the Congo (DRC) yesterday announced a new Ebola case, its first since September, which involves a woman who died from her infection in Butembo, one of the main hot spots in the country's 10th outbreak that was centered in North Kivu and Ituri provinces.

Resistance to 3 or more antibiotics in 13% of serious urinary infections

One in eight US patients hospitalized with a complicated urinary tract infection (cUTI) have a pathogen with resistance to three or more routinely used antibiotic classes, researchers reported yesterday in BMC Infectious Diseases.

Antibiotic prescribing in telehealth can be appropriate with guidance, study finds

Telemedicine visits in Brazil performed under rigorous adherence to antibiotic stewardship guidelines were associated with appropriate antibiotic prescribing for patients with low-risk conditions, Brazilian and Australian researchers reported yesterday in the International Journal of Infectious Diseases.

Global point-prevalence survey helps hospital stewardship, survey finds

Results from a worldwide survey of hospitals suggests that the Global Point Prevalence Survey of Antimicrobial Consumption and Resistance (Global-PPS) has helped inform stewardship activities, Belgian researchers reported this week in Antimicrobial Resistance and Infection Control.

New antimicrobials added to WHO essential medicines list

New antimicrobials to treat severe bacterial and fungal infections were among the drugs that the World Health Organization (WHO) included in its new Essential Medicines list, which is updated annually and serves as its recommended list of medicines that every health system should have.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

New antimicrobials added to WHO essential medicines list

New antimicrobials to treat severe bacterial and fungal infections were among the drugs that the World Health Organization (WHO) included in its new Essential Medicines list, which is updated annually and serves as its recommended list of medicines that every health system should have.

FDA clears new rapid molecular test for antibiotic resistance genes

Diagnostics company OpGen announced today that it has received 510(k) clearance from the US Food and Drug Administration (FDA) to market a new rapid molecular diagnostic tool that could aid in treating antibiotic-resistant or non-susceptible infections.

US stewardship effort tied to lower antibiotics in ambulatory care during COVID

A national ambulatory antibiotic stewardship program was associated with declines in overall and acute respiratory infection (ARI)-related prescribing during the COVID-19 pandemic, US researchers reported last week at ID Week 2021.

WHO recommends malaria vaccine for kids in high-risk areas

The World Health Organization (WHO) today recommended the RTS,S malaria vaccine for children in sub-Saharan Africa and other areas of moderate and high Plasmodium falciparum malaria transmission. The recommendation paves the way for global health groups to make funding and vaccine rollout plans and for countries to decide whether to include vaccination in their malaria control programs.

Estimate: 1 in 500 US children, 65% of them minorities, orphaned by COVID

More than 140,000 US children lost a parent or other caregiver from COVID-19 during the pandemic, representing one caregiver loss for every four coronavirus deaths, suggests a modeling study today in Pediatrics.